Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kevin T O'Brien"'
Computational and experimental analysis of bioactive peptide linear motifs in the integrin adhesome.
Autor:
Kevin T O'Brien, Kalyan Golla, Tilen Kranjc, Darragh O'Donovan, Seamus Allen, Patricia Maguire, Jeremy C Simpson, David O'Connell, Niamh Moran, Denis C Shields
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210337 (2019)
Therapeutic modulation of protein interactions is challenging, but short linear motifs (SLiMs) represent potential targets. Focal adhesions play a central role in adhesion by linking cells to the extracellular matrix. Integrins are central to this pr
Externí odkaz:
https://doaj.org/article/5d77b6ded1384de79e22ff89a22a2a4a
Autor:
Heini eRuhanen, Daniel eHurley, Ambarnil eGhosh, Kevin T O'Brien, Catrióna R Johnston, Denis Colum Shields
Publikováno v:
Frontiers in Microbiology, Vol 5 (2014)
Short linear motifs are functional stretches of protein sequence that are of crucial importance for numerous biological processes by mediating protein-protein interactions. These motifs often comprise peptides of less than ten amino acids that modula
Externí odkaz:
https://doaj.org/article/f97713c2681846d1bd3a855e4b7cadfb
Publikováno v:
Royal Society Open Science, Vol 7, Iss 1 (2020)
Royal Society Open Science
Royal Society Open Science
Background: The polyproline II helix (PPIIH) is an extended protein left-handed secondary structure that usually but not necessarily involves prolines. Short PPIIHs are frequently, but not exclusively, found in disordered protein regions, where they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0817acd1c15a73f01bcff2fc48b021
https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.191239
https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.191239
Autor:
Tilen Kranjc, Seamus Allen, Patricia B. Maguire, Jeremy C. Simpson, Niamh Moran, Kalyan Golla, Kevin T. O’Brien, Darragh O'Donovan, Denis C. Shields, David J. O'Connell
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210337 (2019)
PLoS ONE
PLoS ONE
Therapeutic modulation of protein interactions is challenging, but short linear motifs (SLiMs) represent potential targets. Focal adhesions play a central role in adhesion by linking cells to the extracellular matrix. Integrins are central to this pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45babf818032e52158238467243f7bde
https://doaj.org/article/5d77b6ded1384de79e22ff89a22a2a4a
https://doaj.org/article/5d77b6ded1384de79e22ff89a22a2a4a
Autor:
Emily Olorin, Kevin T. O'Brien, Nicolas Palopoli, Åsa Pérez-Bercoff, Denis C. Shields, Richard J. Edwards
Publikováno v:
F1000Research, Vol 4 (2015)
Short linear motifs (SLiMs) are small protein sequence patterns that mediate a large number of critical protein-protein interactions, involved in processes such as complex formation, signal transduction, localisation and stabilisation. SLiMs show rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::9c934021d9a93591ee2e2b7b8a102f2f
http://f1000research.com/articles/4-477/v1
http://f1000research.com/articles/4-477/v1
Antagonism of quorum sensing represents a promising new antivirulence approach for the treatment of bacterial infection. The development of a novel series of non-natural irreversible antagonists of P. aeruginosa LasR is described. The lead compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7576b2948746ee2c2f71c287bf075a
https://europepmc.org/articles/PMC4329587/
https://europepmc.org/articles/PMC4329587/
Publikováno v:
BMC Bioinformatics
Background Computational protein short linear motif discovery can use protein interaction information to search for motifs among proteins which share a common interactor. Cytoscape provides a visual interface for protein networks but there is no stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a45b2392e9e29bb61687432b197816e
https://pubmed.ncbi.nlm.nih.gov/23855714
https://pubmed.ncbi.nlm.nih.gov/23855714
Many of the specific functions of intrinsically disordered protein segments are mediated by Short Linear Motifs (SLiMs) interacting with other proteins. Well known examples include SLiMs that interact with 14-3-3, PDZ, SH2, SH3, and WW domains but th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bb6710866306d164f531fe984f5f82
https://eprints.soton.ac.uk/210851/
https://eprints.soton.ac.uk/210851/
Autor:
Nora Khaldi, Ilias Stavropoulos, Norman E. Davey, Finian Martin, Denis C. Shields, Kevin T. O’Brien
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44389 (2012)
PLoS ONE
PLoS ONE
Intracellular juxtamembrane regions of transmembrane proteins play pivotal roles in cell signalling, mediated by protein-protein interactions. Disordered protein regions, and short conserved motifs within them, are emerging as key determinants of man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6c1a997f9e75008005d8a94d75c77b
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22962613/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22962613/?tool=EBI
Autor:
Kevin T. O’Brien, Åsa Pérez-Bercoff, Denis C. Shields, Nicolas Palopoli, Emily Olorin, Richard Edwards
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
F1000Research
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
F1000Research
Short linear motifs (SLiMs) are small protein sequence patterns that mediate a large number of critical protein-protein interactions, involved in processes such as complex formation, signal transduction, localisation and stabilisation. SLiMs show rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f025b2931140d52185b41c35422f1c16
https://doi.org/10.12688/f1000research.6773.1
https://doi.org/10.12688/f1000research.6773.1