Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kevin T Lynch"'
Autor:
Nicole L. Edmonds, Sarah E Gradecki, Priya Katyal, Kevin T Lynch, Anne M Stowman, Alejandro A Gru, Victor H Engelhard, Craig L Slingluff, Ileana S. Mauldin
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTTertiary lymphoid structures (TLS) are ectopic lymphoid structures that can arise in human cancers and are associated with improved overall survival (OS) and response to immune checkpoint blockade (ICB) in several cancers, including non-desmo
Externí odkaz:
https://doaj.org/article/76a7c46882b34e41922abb9223121455
Autor:
Walter C Olson, Max O Meneveau, Kevin T Lynch, Christine A Tran, Priya Katyal, Craig L Slingluff,
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Immune-mediated melanoma regression relies on melanoma-reactive T cells infiltrating tumor. Cancer vaccines increase circulating melanoma-reactive T cells, but little is known about vaccine-induced circulating lymphocytes (viCLs) homing to
Externí odkaz:
https://doaj.org/article/47178d74b5a14c51966fd54e06e8bc6a
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background A goal of cancer vaccines is to induce strong T cell responses to tumor antigens, but the delivery method, schedule, and formulation of cancer vaccines have not yet been optimized. Adjuvants serve to increase the immune response against va
Externí odkaz:
https://doaj.org/article/7a00026dec83465a937a3f1d6b787dd0
Autor:
Ileana S Mauldin, Nolan A Wages, Max O Meneveau, Kevin T Lynch, Samuel J Young, Craig L Slingluff Jr, Victor H Engelhard
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Tertiary lymphoid structures (TLSs) are immune aggregates in peripheral tissues that may support adaptive immune responses. Their presence has been associated with clinical response to checkpoint blockade therapy (CBT), but it is unknown w
Externí odkaz:
https://doaj.org/article/bc704d967f104405830c38beb6d775f1
Autor:
Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background Experimental cancer vaccines are traditionally administered by injection in subcutaneous tissue or muscle, commonly with adjuvants that create chronic inflammatory depots. Injection of melanoma-derived peptides induces T cell responses; ho
Externí odkaz:
https://doaj.org/article/f51a03367fd14cc38bf39a029258d603
Autor:
Ileana S Mauldin, Marit M Melssen, Stephen Turner, Pankaj Kumar, Karlyn E Pollack, Max O Meneveau, Kevin T Lynch, Alexander F Koeppel, Samuel J Young, Katia Sol-Church, Craig L Slingluff Jr
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Immunogenicity of cancer vaccines is impacted by adjuvants and schedule, but systematic assessments of their effects have not been performed. Montanide ISA-51, an incomplete Freund’s adjuvant (IFA), is used in many vaccine trials, but co
Externí odkaz:
https://doaj.org/article/23619684f92f4a40b5f5f46f722ea09b
Autor:
William J. Kane, Mark A. Fleming, Kevin T. Lynch, Charles M. Friel, Michael D. Williams, Traci L. Hedrick, Guofen Yan, Sook C. Hoang
Publikováno v:
Diseases of the colon and rectum.
Racial and ethnic disparities in receipt of recommended colorectal cancer screening exist, however the impact of social determinants of health on such disparities has not been recently studied in a national cohort.The objective of this study was to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bb16352d886655ad97b0927ba13628
https://pubmed.ncbi.nlm.nih.gov/35533321
https://pubmed.ncbi.nlm.nih.gov/35533321
Autor:
Kevin T. Lynch, Taryn E. Hassinger
Publikováno v:
Clinics in Colon and Rectal Surgery. 36:161-166
Preoperative anemia is a common finding in patients undergoing colorectal surgery, particularly those with cancer. While often multifactorial, iron deficiency anemia remains the most common cause of anemia in this patient population. Although seeming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65b470c1f534fd24da363b61b83bc90a
https://doi.org/10.1055/s-0043-1760868
https://doi.org/10.1055/s-0043-1760868
Autor:
Max O. Meneveau, Rick D. Vavolizza, Anwaruddin Mohammad, Pankaj Kumar, Joseph T. Manderfield, Colleen Callahan, Kevin T. Lynch, Tarek Abbas, Craig L. Slingluff, Stefan Bekiranov
Publikováno v:
Annals of surgery.
Develop a predictive model to identify patients with 1 pathologic LN (pLN) versus1pLN using machine learning applied to gene expression profiles and clinical data as input variables.Standard management for clinically detected melanoma lymph node (cLN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4410c4c2446ed10066886afeba42a3d
https://pubmed.ncbi.nlm.nih.gov/36538614
https://pubmed.ncbi.nlm.nih.gov/36538614
Autor:
Jennifer Y Ju, Paul R. Kunk, Kevin T. Lynch, Kevin Winters, Max O. Meneveau, Osama E. Rahma, Joseph M. Obeid, Sean C. Dougherty, Todd W. Bauer, Edward B. Stelow, Craig L. Slingluff, Rachel Whitehair
Publikováno v:
J Immunother
Cholangiocarcinoma (CC) is an uncommon malignancy with increasing incidence and dismal prognosis. We conducted a comprehensive analysis of the CC tumor immune microenvironment (TIME) based on tumor location to identify therapeutic targets. We hypothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b35c731d05cf36a54092fac8dfb6ad
https://doi.org/10.1097/cji.0000000000000378
https://doi.org/10.1097/cji.0000000000000378