Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kevin T Breen"'
Autor:
Kevin T Breen, Sarah R Anderson, Michael R Steele, David J Calkins, Alejandra Bosco, Monica L Vetter
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Neurodegeneration in glaucoma results in decline and loss of retinal ganglion cells (RGCs), and is associated with activation of myeloid cells such as microglia and macrophages. The chemokine fractalkine (FKN or Cx3cl1) mediates communication from ne
Externí odkaz:
https://doaj.org/article/6be63ddc9aba4e128bfb3400c54d959b
Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma
Autor:
Sarah R. Anderson, Monica L. Vetter, Alejandra Bosco, Kevin T. Breen, Michael R. Steele, David J. Calkins
Publikováno v:
Experimental Eye Research. 150:34-43
Within the white matter, axonal loss by neurodegeneration is coupled to glial cell changes in gene expression, structure and function commonly termed gliosis. Recently, we described the highly variable expansion of gliosis alebosco@neuro.utah.edu in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b24bd70f460a05f61ff9b08315f643
https://doi.org/10.1016/j.exer.2016.01.014
https://doi.org/10.1016/j.exer.2016.01.014
Autor:
Alejandra Bosco, Michael R. Steele, Cesar O. Romero, William W. Hauswirth, Sanford L. Boye, Kevin T. Breen, Vince A. Chiodo, Sarah R. Anderson, Stephen Tomlinson, Monica L. Vetter
Dysregulation of the complement system is implicated in neurodegeneration, including human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by local complement upregulation and activation, but whether targeting this early i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1ea28ca67073736646c85b51a0105c
https://doi.org/10.1101/369181
https://doi.org/10.1101/369181
Autor:
Alejandra Bosco, Cesar O. Romero, Balamurali K. Ambati, Michael R. Steele, Kevin T. Breen, Alexis A. Chagovetz, Monica L. Vetter
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 5, Pp 443-455 (2015)
Disease Models & Mechanisms
Disease Models & Mechanisms
Microglia serve key homeostatic roles, and respond to neuronal perturbation and decline with a high spatiotemporal resolution. The course of all chronic CNS pathologies is thus paralleled by local microgliosis and microglia activation, which begin at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7e6a8fedf3239d85077995ab84464f
https://doi.org/10.1242/dmm.018788
https://doi.org/10.1242/dmm.018788
Autor:
Alejandra Bosco, William W. Hauswirth, Sarah R. Anderson, V. Chiodo, Kevin T. Breen, Cesar O. Romero, Sanford L. Boye, Michael R. Steele, Monica L. Vetter, Stephen Tomlinson
Publikováno v:
Acta Ophthalmologica. 95
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce7f0da58d9f7d6b7d9da9626fd65b87
https://doi.org/10.1111/j.1755-3768.2017.03621
https://doi.org/10.1111/j.1755-3768.2017.03621
Autor:
Alejandra Bosco, Kevin T. Breen, Monica L. Vetter, Michael R. Steele, David J. Calkins, Sarah R. Anderson
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Frontiers in Neuroscience
Frontiers in Neuroscience
Neurodegeneration in glaucoma results in decline and loss of retinal ganglion cells (RGCs), and is associated with activation of myeloid cells such as microglia and macrophages. The chemokine fractalkine (FKN or Cx3cl1) mediates communication from ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b88e7643b1c7337ba3a891856c6619
http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00526/full
http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00526/full
Autor:
Alejandra Bosco, Sanford Boyle, Monica L. Vetter, William W. Hauswirth, Stephen Tomlinson, Kevin T. Breen, Cesar O. Romero, Vince A. Chiodo, Sarah R. Anderson, Michael R. Steele
Publikováno v:
Molecular Immunology. 102:136
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fae7181b72ca7479b610138a44afded0
https://doi.org/10.1016/j.molimm.2018.06.035
https://doi.org/10.1016/j.molimm.2018.06.035
Autor:
Christopher W. Peterson, Andrew N. Billin, Donald E. Ayer, Carrie A. Stoltzman, Deborah M. Muoio, Kevin T. Breen
Publikováno v:
Proceedings of the National Academy of Sciences. 105:6912-6917
Glucose is a fundamental metabolite, yet how cells sense and respond to changes in extracellular glucose concentration is not completely understood. We recently reported that the MondoA:Mlx dimeric transcription factor directly regulates glycolysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f3ced363db1bab910a8649ec9921e4
https://doi.org/10.1073/pnas.0712199105
https://doi.org/10.1073/pnas.0712199105
Autor:
Kevin T. Breen, Christopher L. Sans, Carrie A. Stoltzman, Daniel J. Satterwhite, Donald E. Ayer
Publikováno v:
Molecular and Cellular Biology. 26:4863-4871
Transcription factors can be sequestered at specific organelles and translocate to the nucleus in response to changes in organellar homeostasis. MondoA is a basic helix-loop-helix leucine zipper transcriptional activator similar to Myc in function. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d7fbd64512cb55881aa2ac6d618d42
https://doi.org/10.1128/mcb.00657-05
https://doi.org/10.1128/mcb.00657-05
Publikováno v:
Developmental biology. 310(2)
Myc and Mondo proteins are key regulators of cell growth, proliferation, and energy metabolism, yet often overlooked is their vital role in cell migration. Complex networks of protein–protein and protein–DNA interactions control the transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925465e0140fa9d9d0009b95ebb6b514
https://pubmed.ncbi.nlm.nih.gov/17826759
https://pubmed.ncbi.nlm.nih.gov/17826759