Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kevin Spehar"'
Autor:
Iryna Benilova, Niraja Kedia, Sheena E. Radford, Frank Sobott, Yuanzi Sun, Richard B. Sessions, Mark Batchelor, Kevin Spehar, Byron Caughey, John Collinge, George R. Nahass, Jan Bieschke, Parmjit S. Jat, Yong Xu, Madeleine Reilly
Publikováno v:
J Mol Biol
Alpha-synuclein (α-syn) fibrils, a major constituent of the neurotoxic Lewy Bodies in Parkinson's disease, form via nucleation dependent polymerization and can replicate by a seeding mechanism. Brazilin, a small molecule derived from red cedarwood t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55c114974433c8a6182b286c4ef1444
Autor:
Yuanzi Sun, Byron Caughey, Mark Batchelor, Frank Sobott, John Collinge, Parmjit S. Jat, Niraja Kedia, Richard B. Sessions, Kevin Spehar, Madeleine Reilly, Jan Bieschke, Sheena E. Radford, Iryna Benilova, George R. Nahass, Yong Xu
Alpha-synuclein (α-syn) fibrils, a major constituent of the neurotoxic Lewy Bodies in Parkinson’s disease, form via nucleation dependent polymerization and can replicate by a seeding mechanism. Brazilin, a small molecule derived from red cedarwood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d637558d8c043608abab42f3ee67abae
https://doi.org/10.1101/2020.09.29.318220
https://doi.org/10.1101/2020.09.29.318220
Publikováno v:
Stem Cells
Stem cell dysfunction is a hallmark of aging, associated with the decline of physical and cognitive abilities of humans and other mammals [Cell 2013;153:1194]. Therefore, it has become an active area of research within the aging and stem cell fields,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4531773999b20083856bc4214b666f
https://pubmed.ncbi.nlm.nih.gov/32473067
https://pubmed.ncbi.nlm.nih.gov/32473067
Long-term, super-resolution imaging of amyloid structures using transient amyloid binding microscopy
Publikováno v:
Single Molecule Spectroscopy and Superresolution Imaging XII.
Amyloid fibrils and tangles are signatures of Alzheimer disease, but nanometer-sized aggregation intermediates are hypothesized to be the structures most toxic to neurons. The structures of these oligomers are too small to be resolved by conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efba797240d204f1bafcf5fcdc210468
https://doi.org/10.1117/12.2507656
https://doi.org/10.1117/12.2507656
Autor:
Kevin Spehar, George R. Nahass, Tianben Ding, Matthew D. Lew, Jan Bieschke, Jin Lu, Yuanzi Sun, Niraja Kedia
Publikováno v:
Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP).
Amyloids are implicated in Alzheimer’s disease but cannot be well resolved by standard light microscopy. We developed a tool to directly image native amyloid structures and dynamics at nanometer resolution over minutes to days.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03671f1664ca3f617eda7a6a50ce041f
https://doi.org/10.1364/omp.2019.ow4d.4
https://doi.org/10.1364/omp.2019.ow4d.4
Autor:
Yuanzi Sun, Kevin Spehar, Jin Lu, George R. Nahass, Matthew D. Lew, Tianben Ding, Jan Bieschke
Publikováno v:
Biophysical Journal. 114:346a-347a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99eaddf8366b06093c3d74a814adef2d
https://doi.org/10.1016/j.bpj.2017.11.1934
https://doi.org/10.1016/j.bpj.2017.11.1934
Autor:
Kevin Spehar, Tianben Ding, Jin Lu, Yuanzi Sun, George R. Nahass, Niraja Kedia, Matthew D. Lew, Jan Bieschke
Publikováno v:
Biophysical Journal. 116:458a
Oligomeric amyloid structures are crucial therapeutic targets in Alzheimer’s and other amyloid diseases. However, these oligomers are too small to be resolved by standard light microscopy. We have developed a simple and versatile tool to image amyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3332e8a4325e0b3b5360b7c6e3b4c058
https://doi.org/10.1016/j.bpj.2018.11.2471
https://doi.org/10.1016/j.bpj.2018.11.2471
Autor:
Matthew D. Lew, Kevin Spehar, Yuanzi Sun, Jin Lu, Niraja Kedia, Tianben Ding, Jan Bieschke, George R. Nahass
Publikováno v:
ChemBioChem. 19:1897-1897
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dae58bac62341baeeb0be7c16ef01f86
https://doi.org/10.1002/cbic.201800489
https://doi.org/10.1002/cbic.201800489