Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kevin Shieh"'
Autor:
Kevin Shieh, Elizabeth Brem
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-4 (2024)
Abstract Central nervous system (CNS) relapse of diffuse large B-cell lymphoma (DLBCL) is associated with a poor prognosis, with a median overall survival of approximately five months [1]. The risk for CNS disease has been estimated to be about 5% ov
Externí odkaz:
https://doaj.org/article/fe5826bdd72f431ea283d7638abfb123
Autor:
Behnam Nabet, Pilib Ó Broin, Jaime M. Reyes, Kevin Shieh, Charles Y. Lin, Christine M. Will, Relja Popovic, Teresa Ezponda, James E. Bradner, Aaron A. Golden, Jonathan D. Licht
Publikováno v:
Cell Reports, Vol 12, Iss 8, Pp 1300-1313 (2015)
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of n
Externí odkaz:
https://doaj.org/article/d46a0408c3ce460aa11345d0ea1375f4
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Frontiers in Medicine
Frontiers in Medicine
Background: Checkpoint inhibitor immunotherapy or immuno-oncology (IO) treatment in refractory cervical cancer yielded an objective response rate (ORR) of 12% in tumors expressing the programmed cell death ligand-1 (PD-L1) in the KEYNOTE-158 phase II
Autor:
Aaron Golden, Christina Kratschmer, Kevin Shieh, Levy Matthew, Keith E. Maier, John M. Greally
Publikováno v:
Bioinformatics
Summary High-throughput sequencing can enhance the analysis of aptamer libraries generated by the Systematic Evolution of Ligands by EXponential enrichment. Robust analysis of the resulting sequenced rounds is best implemented by determining a ranked
Autor:
Yiwu Huang, William B. Solomon, Yiqing Xu, Zhen Wang, Lan Mo, Kevin Becker, Jason Sandler, Kevin Shieh
Publikováno v:
Journal of Clinical Oncology. 38:e21658-e21658
e21658 Background: First-line treatment of lung cancer patients with EGFR mutation with early generation tyrosine kinase inhibitors (TKIs) renders a median progression-free survival (mPFS) of 11 months (m), and for the patients who subsequently devel
Autor:
Kevin Shieh, Charles Y. Lin, James E. Bradner, Teresa Ezponda, Aaron Golden, Relja Popovic, Christine Will, Jaime M. Reyes, Pilib Ó Broin, Jonathan D. Licht, Behnam Nabet
Publikováno v:
Cell Reports, Vol 12, Iss 8, Pp 1300-1313 (2015)
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRas(G12V) or loss of
Publikováno v:
ICSC
Systems biology approaches to the integrative study of cells, organs and organisms offer the best means of understanding in a holistic manner the diversity of molecular assays that can be now be implemented in a high throughput manner. Such assays ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ee69860029bade186ddac34038f0b0
http://arxiv.org/abs/1604.05189
http://arxiv.org/abs/1604.05189
Autor:
Rohit K. Jangra, David K. Cureton, Kevin Shieh, Matthew Levy, Erik L. Snapp, Sean P. J. Whelan, Hui Xiao, Kartik Chandran, Keith E. Maier
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Pathogenic New World hemorrhagic fever mammarenaviruses (NWM) utilize Glycoprotein 1 (GP1) to target the apical domain of the human transferrin receptor (hTfR) for facilitating cell entry. However, the conservation between their GP1s is low. Consider
Publikováno v:
XSEDE
RNA aptamers are small oligonucleotide molecules whose composition and resulting folded structure enable them to bind with high affinity and high selectivity to target ligands and therefore hold great promise as potential therapeutic drugs. Functiona
Publikováno v:
XSEDE
The use of sequencing technologies has revolutionized the field of genomics, allowing us to study structural and functional variations within the genome to base pair level. These technologies can also be used to probe the associated epigenome, where