Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kevin Seekell"'
Publikováno v:
Methods. 56:310-316
Noble metal nanoparticles hold great potential as optical contrast agents due to a unique feature, known as the plasmon resonance, which produces enhanced scattering and absorption at specific frequencies. The plasmon resonance also provides a spectr
Publikováno v:
Biomedical Optics 2014.
We present a fast wide-field holography system for detecting the photothermally excited gold nanospheres in a QPI scheme. An interferometric optical lock-in approach was shown to improve SNR for detecting nanoparticles on multiple substrates.
Publikováno v:
Biomedical optics express. 4(11)
Effective treatment of patients with malignant brain tumors requires surgical resection of a high percentage of the bulk tumor. Surgeons require a method that enables delineation of tumor margins, which are not visually distinct by eye. In this study
Multispectral nanoparticle contrast agents for true-color spectroscopic optical coherence tomography
Publikováno v:
Biomedical Optics Express
We have recently developed a novel dual window scheme for processing spectroscopic OCT images to provide spatially resolved true color imaging of chromophores in scattering samples. Here we apply this method to measure the extinction spectra of plasm
Publikováno v:
Scopus-Elsevier
We have recently developed METRiCS OCT to provide spatially resolved molecular information of chromosomes. Here we apply this method to measure the extinction spectra of nanoparticles at various concentrations for potential in vivo applications.
Publikováno v:
ACS nano. 5(11)
The dimerization of receptors on the cell membrane is an important step in the activation of cell signaling pathways. Several methods exist for observing receptor dimerization, including coimmunoprecipitation, chemical cross-linking, and fluorescence
Publikováno v:
Scopus-Elsevier
Gold nanorods are candidates for tumor delineation due to their unique optical properties and biocompatibility. The optical characteristics of nanorods are tuned during synthesis. Anti-EGFR nanorods effectively label tumors within brain slices.
Publikováno v:
Biomedical Optics and 3-D Imaging.
Single gold nanospheres sense local dielectric environment but are influenced by plasmonic coupling of proximal pairs. Polarization control separates these two effects, allowing both RI sensing and measurement of interparticle distance, with potentia
Autor:
Adam Wax, Julie H. Ostrander, Ashutosh Chilkoti, Stella M. Marinakos, Kevin Seekell, Matthew J. Crow
Publikováno v:
Journal of Biomedical Optics. 16:116003
This work presents simultaneous imaging and detection of three different cell receptors using three types of plasmonic nanoparticles (NPs). The size, shape, and composition-dependent scattering profiles of these NPs allow for a system of multiple dis
Publikováno v:
Optics Letters. 36:757
We propose the use of polarization mapping as a tool to better separate the effects of plasmonic coupling from the local refractive index for molecular imaging and biosensing using gold nanoparticles. Polarization mapping allows identification of the