Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kevin S. Ratliff"'
Autor:
Dann L. Parker, Randal M. Bugianesi, Birgit T. Priest, Feroze Ujjainwalla, Edward C. Sherer, Stanley Mitelman, Sharon Tong, Matthew Lombardo, William K. Hagmann, Ravi P. Nargund, Melissa Costa, Christopher Joseph Sinz, Anka G. Ehrhardt, Scott D. Edmondson, Ravi Kurukulasuriya, Xiaofang Li, Karen H. Dingley, Kate Bender, Kevin S. Ratliff, Jonathan E. Wilson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2947-2951
A novel series of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists are described. The series was designed to address the suboptimal PK (pharmacokinetic) and off-target profile of a class of N-aryl-benzo-[1,4]-oxazepine-4-carboxamides, represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f4fd9aaf407b2d77d08816feb7cb20
https://doi.org/10.1016/j.bmcl.2016.04.018
https://doi.org/10.1016/j.bmcl.2016.04.018
Autor:
Stephen P. Arneric, Vivien A. Warren, Joseph L. Duffy, Owen B. McManus, James B Herrington, Clare London, Terrance P. Snutch, Rodolfo Haedo, Randal M. Bugianesi, Gregory J. Kaczorowski, Ge Dai, Cyrus Eduljee, Scott B. Hoyt, David Parker, McHardy M. Smith, Andrew M. Swensen, Kevin S. Ratliff
Publikováno v:
Molecular Pharmacology. 81:488-497
Biological, genetic, and clinical evidence provide validation for N-type calcium channels (Ca V 2.2) as therapeutic targets for chronic pain. A state-dependent Ca V 2.2 inhibitor may provide an improved therapeutic window over ziconotide, the peptidy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec267e20b4e339380c1bc9d081bfad8
https://doi.org/10.1124/mol.111.075226
https://doi.org/10.1124/mol.111.075226
Autor:
Alison Rush, James B Herrington, Rodolfo Haedo, Mark E. Williams, Owen B. McManus, McHardy M. Smith, Andrew M. Swensen, Ge Dai, Kevin S. Ratliff, Randal M. Bugianesi, Vivien A. Warren
Publikováno v:
ASSAY and Drug Development Technologies. 6:195-212
Cav2.2 channels play a critical role in pain signaling by controlling synaptic transmission between dorsal root ganglion neurons and dorsal horn neurons. The Cav2.2-selective peptide blocker ziconotide (Prialt, Elan Pharmaceuticals, Dublin, Ireland)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54940784e8ad45d85e6d7baf0b563e61
https://doi.org/10.1089/adt.2008.136
https://doi.org/10.1089/adt.2008.136
Publikováno v:
Nature Structural & Molecular Biology. 11:830-837
The proteasome is the main ATP-dependent protease in eukaryotic cells and controls the concentration of many regulatory proteins in the cytosol and nucleus. Proteins are targeted to the proteasome by the covalent attachment of polyubiquitin chains. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cafbd402ac696b040f1ecb6fe8e1ee8
https://doi.org/10.1038/nsmb814
https://doi.org/10.1038/nsmb814
Publikováno v:
Nature Structural Biology. 9:301-307
Mitochondria can unfold importing precursor proteins by unraveling them from their N-termini. However, how this unraveling is induced is not known. Two candidates for the unfolding activity are the electrical potential across the inner mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62a87513ae703aaf13995c770aa0e08
https://doi.org/10.1038/nsb772
https://doi.org/10.1038/nsb772
Autor:
Shihai Huang, Michael P. Schwartz, Jonathan M. Spenner, Andreas T Matouschek, Kevin S. Ratliff
Publikováno v:
Nature Structural Biology. 6:1132-1138
Protein unfolding is a key step in the life cycle of many proteins, including certain proteins that are degraded by ATP-dependent proteases or translocated across membranes. The detailed mechanisms of these unfolding processes are not understood. Pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d72af24615f1c8ea7144f4294fd0dad8
https://doi.org/10.1038/70073
https://doi.org/10.1038/70073
Autor:
Gregory J. Kaczorowski, Yun-Ping Zhou, László L. Kiss, James B Herrington, Kelli Solly, Ranjit Desai, Andrew W. Howard, Yusheng Xiong, Nina Li, Owen B. McManus, Maria L. Garcia, Qiaolin Deng, Kevin S. Ratliff
Publikováno v:
Molecular pharmacology. 80(6)
Identification of selective ion channel inhibitors represents a critical step for understanding the physiological role that these proteins play in native systems. In particular, voltage-gated potassium (K(V)2) channels are widely expressed in tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e6cc6faae10550340e30326745a507
https://pubmed.ncbi.nlm.nih.gov/21948463
https://pubmed.ncbi.nlm.nih.gov/21948463
Autor:
Gregory J. Kaczorowski, James B Herrington, Kevin S. Ratliff, William A. Schmalhofer, Maria L. Garcia, Adam B. Weinglass
Publikováno v:
Channels (Austin, Tex.). 3(6)
Gating modifier peptides alter gating of voltage-gated potassium (KV) channels by binding to the voltage sensor paddle and changing the energetics of channel opening. Since the voltage sensor paddle is a modular motif with low sequence similarity acr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c73f3d78394b33bfcc559f566fc6cf
https://pubmed.ncbi.nlm.nih.gov/21150283
https://pubmed.ncbi.nlm.nih.gov/21150283
Autor:
Catherine Abbadie, Brande S. Williams, Bindhu V. Karanam, Joseph L. Duffy, James B Herrington, Maria Madeira, Xiaohua Li, Vivien A. Warren, Michael J. Forrest, Andrew M. Swensen, Sriram Tyagarajan, Bishan Zhou, Prasun K. Chakravarty, Kathryn A. Lyons, Mitchell D. Green, Nina Jochnowitz, Kevin S. Ratliff, Erin McGowan, Owen B. McManus, Randall M. Bugianesi, McHardy M. Smith, Maria L. Garcia, Min Park, Gregory J. Kaczorowski, Shruti Mistry, Rodolfo Haedo
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(2)
N-type calcium channels (Ca(v)2.2) have been shown to play a critical role in pain. A series of low molecular weight 2-aryl indoles were identified as potent Ca(v)2.2 blockers with good in vitro and in vivo potency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f216a0cbc669778ea8da563217bc1cbf
https://pubmed.ncbi.nlm.nih.gov/21195616
https://pubmed.ncbi.nlm.nih.gov/21195616
Autor:
Kevin S. Ratliff, Clifford P. Kubiak
Publikováno v:
Israel Journal of Chemistry. 31:3-15
The activation of CO2 by chemical, electrochemical, and photochemical means is discussed. Binuclear transition metal complexes mediate oxygen atom transfers from CO2 by three distinct chemical pathways: (i) deoxygenation of CO2, (ii) multiple bond me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d0eb4c6e1fc9954385acc23790ae794
https://doi.org/10.1002/ijch.199100002
https://doi.org/10.1002/ijch.199100002