Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Kevin S. O'Connell"'
Autor:
Shahram Bahrami, Kaja Nordengen, Jaroslav Rokicki, Alexey A. Shadrin, Zillur Rahman, Olav B. Smeland, Piotr P. Jaholkowski, Nadine Parker, Pravesh Parekh, Kevin S. O’Connell, Torbjørn Elvsåshagen, Mathias Toft, Srdjan Djurovic, Anders M. Dale, Lars T. Westlye, Tobias Kaufmann, Ole A. Andreassen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ga
Externí odkaz:
https://doaj.org/article/2f1f263ef851499c8530865075d76cf0
Autor:
Hasan Çağın Lenk, Elise Koch, Kevin S. O’Connell, Robert Løvsletten Smith, Ibrahim A. Akkouh, Srdjan Djurovic, Ole A. Andreassen, Espen Molden
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-9 (2024)
Abstract Background Treatment resistant schizophrenia (TRS) is broadly defined as inadequate response to adequate treatment and is associated with a substantial increase in disease burden. Clozapine is the only approved treatment for TRS, showing sup
Externí odkaz:
https://doaj.org/article/369f22af251e4c118addb20133152a72
Autor:
Olivia Wootton, Alexey A. Shadrin, Thomas Bjella, Olav B. Smeland, Dennis van der Meer, Oleksandr Frei, Kevin S. O’Connell, Torill Ueland, Ole A. Andreassen, Dan J. Stein, Shareefa Dalvie
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cognitive impairment is a major determinant of functional outcomes in schizophrenia, however, understanding of the biological mechanisms underpinning cognitive dysfunction in the disorder remains incomplete. Here, we apply Genomic Structural
Externí odkaz:
https://doaj.org/article/7f13ff9d04ba4cabb368c63148f5460b
Autor:
Dimitrios Andreou, Nils Eiel Steen, Lynn Mørch-Johnsen, Kjetil Nordbø Jørgensen, Laura A. Wortinger, Claudia Barth, Attila Szabo, Kevin S. O’Connell, Tove Lekva, Gabriela Hjell, Ingrid Torp Johansen, Monica B. E. G. Ormerod, Unn K. Haukvik, Pål Aukrust, Srdjan Djurovic, Robert H. Yolken, Ole A. Andreassen, Thor Ueland, Ingrid Agartz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Toxoplasma gondii (TOXO) infection typically results in chronic latency due to its ability to form cysts in the brain and other organs. Latent toxoplasmosis could promote innate immune responses and impact brain function. A large body of evi
Externí odkaz:
https://doaj.org/article/b28087d04ced4d7b991fef08dfdc10c3
Autor:
Markos Tesfaye, Piotr Jaholkowski, Guy F. L. Hindley, Alexey A. Shadrin, Zillur Rahman, Shahram Bahrami, Aihua Lin, Børge Holen, Nadine Parker, Weiqiu Cheng, Linn Rødevand, Oleksandr Frei, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Ole A. Andreassen
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of the heritability rema
Externí odkaz:
https://doaj.org/article/d4cf61f95eec4b69bd69fd5c62edd34e
Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood
Autor:
Ragna Bugge Askeland, Laurie J. Hannigan, Kevin S. O’Connell, Elizabeth C. Corfield, Oleksandr Frei, Anita Thapar, George Davey Smith, Ted Reichborn-Kjennerud, Ole A. Andreassen, Helga Ask, Alexandra Havdahl
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Knowledge on how genetic risk for bipolar disorder manifests in developmental, emotional or behavioral traits during childhood is lacking. This issue is important to address to inform early detection and intervention efforts. We investigated
Externí odkaz:
https://doaj.org/article/485b0cfcb2454cb8b7b71cb3b2f84e94
Autor:
Robert Løvsletten Smith, Birgit M. Wollmann, Elisabet Størset, Hasan Çağın Lenk, Kevin S. O'Connell, Marianne Kringen Kristiansen, Magnus Ingelman‐Sundberg, Espen Molden
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract Cytochrome P450 2D6 (CYP2D6) is important for metabolism of 20%–25% of all clinically used drugs. Many known genetic variants contribute to the large interindividual variability in CYP2D6 metabolism, but much is still unexplained. We recen
Externí odkaz:
https://doaj.org/article/bc583d3f16e243a881eff9ea3dbfb57a
Autor:
Hasan Çağın Lenk, Robert Løvsletten Smith, Kevin S. O'Connell, Marin M. Jukić, Marianne Kristiansen Kringen, Ole A. Andreassen, Magnus Ingelman‐Sundberg, Espen Molden
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 1, Pp 62-72 (2023)
Abstract Clinical response of clozapine is closely associated with serum concentration. Although tobacco smoking is the key environmental factor underlying interindividual variability in clozapine metabolism, recent genome‐wide studies suggest that
Externí odkaz:
https://doaj.org/article/b404641d026a4bb681d473f000373fe3
Autor:
Guy Hindley, Shahram Bahrami, Nils Eiel Steen, Kevin S. O’Connell, Oleksandr Frei, Alexey Shadrin, Francesco Bettella, Linn Rødevand, Chun C. Fan, Anders M. Dale, Srdjan Djurovic, Olav B. Smeland, Ole A. Andreassen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and associated with poor health outco
Externí odkaz:
https://doaj.org/article/c366b87c22cf4cc282473524c3c42ec0
Autor:
Linn Rødevand, Shahram Bahrami, Oleksandr Frei, Yunhan Chu, Alexey Shadrin, Kevin S. O’Connell, Olav B. Smeland, Torbjørn Elvsåshagen, Guy F. L. Hindley, Srdjan Djurovic, Anders M. Dale, Trine V. Lagerberg, Nils Eiel Steen, Ole A. Andreassen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD), despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP remain largely unknown. We investigated polygenic overlap between
Externí odkaz:
https://doaj.org/article/df29ce5597ec4670ae2c6751050c2698