Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kevin S. Dingwell"'
Autor:
Christo P. Christov, Kevin S. Dingwell, Mark Skehel, Helen S. Wilkes, Julian E. Sale, James C. Smith, Torsten Krude
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2265-2278 (2018)
Summary: DNA replication in the embryo of Xenopus laevis changes dramatically at the mid-blastula transition (MBT), with Y RNA-independent random initiation switching to Y RNA-dependent initiation at specific origins. Here, we identify xNuRD, an MTA2
Externí odkaz:
https://doaj.org/article/6a015015619d447ca39808fc6098d22e
Autor:
Matteo Villa, Stefania Crotta, Kevin S. Dingwell, Elizabeth M. A. Hirst, Manolis Gialitakis, Helena Ahlfors, James C. Smith, Brigitta Stockinger, Andreas Wack
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that thi
Externí odkaz:
https://doaj.org/article/2586c152044d48ffa6ee83a3bf1f6f6c
Autor:
Lina Herhaus, Mazin A. Al-Salihi, Kevin S. Dingwell, Timothy D. Cummins, Lize Wasmus, Janis Vogt, Richard Ewan, David Bruce, Thomas Macartney, Simone Weidlich, James C. Smith, Gopal P. Sapkota
Publikováno v:
Open Biology, Vol 4, Iss 5 (2014)
Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and
Externí odkaz:
https://doaj.org/article/06f0ae8e5ef54e46ac0ae0d065895ee5
Autor:
Janis Vogt, Kevin S. Dingwell, Lina Herhaus, Robert Gourlay, Thomas Macartney, David Campbell, James C. Smith, Gopal P. Sapkota
Publikováno v:
Open Biology, Vol 4, Iss 2 (2014)
Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8. In the canonical pathway, this triggers the
Externí odkaz:
https://doaj.org/article/cd09befeb687451bb7705bf7e0827b03
Autor:
Joshua C. Bufton, Daniel M. Pinkas, Karen Dunbar, Sabin Shrestha, Timothy D. Cummins, Gopal P. Sapkota, Kevin S. Dingwell, James C. Smith, Luke J. Fulcher, Polyxeni Bozatzi, Alex N. Bullock, Joby Varghese, Theresa Tachie-Menson, Simone Weidlich, Nicola T. Wood, Thomas Macartney, Robert Gourlay, David G. Campbell, Kevin Z. L. Wu
The casein kinase 1 (CK1) family of serine-threonine protein kinases are implicated in the regulation of many cellular processes, including the cell cycle, circadian rhythms, and Wnt and Hedgehog signalling. It is therefore critically important to un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0694906ffe7c00e07e8c7af4fb3e5210
https://doi.org/10.1126/scisignal.aao2341
https://doi.org/10.1126/scisignal.aao2341
Autor:
Polyxeni, Bozatzi, Kevin S, Dingwell, Kevin Zl, Wu, Fay, Cooper, Timothy D, Cummins, Luke D, Hutchinson, Janis, Vogt, Nicola T, Wood, Thomas J, Macartney, Joby, Varghese, Robert, Gourlay, David G, Campbell, James C, Smith, Gopal P, Sapkota
Publikováno v:
EMBO Reports
The BMP and Wnt signalling pathways determine axis specification during embryonic development. Our previous work has shown that PAWS1 (also known as FAM83G) interacts with SMAD1 and modulates BMP signalling. Here, surprisingly, we show that overexpre
Autor:
Alan R. Prescott, Gopal P. Sapkota, Joby Varghese, Thomas Macartney, Timothy D. Cummins, James C. Smith, David G. Campbell, Kevin S. Dingwell, Nicola T. Wood, Polyxeni Bozatzi, Eric R. Griffis, Robert Gourlay, Kevin Z. L. Wu
Our previous studies of PAWS1 (Protein Associated With SMAD1) have suggested that this molecule has roles beyond BMP signalling. To investigate these roles, we have used CRISPR/Cas9 to generate PAWS1 knockout cells. Here, we show that PAWS1 plays a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393e10ddac51f753206db0fcd9f2e88e
Autor:
Elizabeth M. A. Hirst, Brigitta Stockinger, Stefania Crotta, Matteo Villa, Andreas Wack, Helena Ahlfors, Kevin S. Dingwell, James C. Smith, Manolis Gialitakis
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Epithelia function as barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). However, AhR function in these tissues is unknown. Here we show that AhR regulates multiciliogenesis in both murine air
Autor:
Kevin S. Dingwell, James C. Smith
Publikováno v:
Cold Spring Harbor Protocols. 2018:pdb.prot097329
The animal cap explant is a simple but adaptable tool available to developmental biologists. The use of animal cap explants in demonstrating the presence of mesoderm-inducting activity in the Xenopus embryo vegetal pole is one of many elegant example
Publikováno v:
Developmental Biology. 336(2):313-326
Signalling by members of the FGF family is required for induction and maintenance of the mesoderm during amphibian development. One of the downstream effectors of FGF is the SRF-interacting Ets family member Elk-1, which, after phosphorylation by MAP