Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kevin S. Chua"'
Autor:
Ronald E. Gress, Francis A. Flomerfelt, Veena Kapoor, Lee A. Hugar, Philip J. Lucas, Kevin S. Chua, Nahed El-Kassar, Baishakhi Choudhury
Publikováno v:
International Immunology. 24:661-671
IL-7 signaling is required for thymocyte development and its loss has a severe deleterious effect on thymus function. Thymocyte–stromal cell interactions and other mechanisms tightly regulate IL-7 expression. We show that disruption of that regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3c60415c1976720b244f3cbb8ba0e9
https://doi.org/10.1093/intimm/dxs067
https://doi.org/10.1093/intimm/dxs067
Autor:
Robert Korngold, Claude Sportes, Michel Morre, Thomas A. Fleisher, Hua Zhang, Sarfraz Memon, Crystal L. Mackall, Terry J. Fry, Rebecca Babb, Catherine Chow, Renaud Buffet, Kevin S. Chua, Julie Engels, Robert J. Amato, Ronald E. Gress, David Venzon, Andrew L. Pecora, Margaret R. Brown, Frances T. Hakim, Michael Krumlauf
Publikováno v:
The Journal of Experimental Medicine
Interleukin-7 (IL-7) is a homeostatic cytokine for resting T cells with increasing serum and tissue levels during T cell depletion. In preclinical studies, IL-7 therapy exerts marked stimulating effects on T cell immune reconstitution in mice and pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912dad01c31c5fd7baecf2a8b9425112
https://doi.org/10.1084/jem.20071681
https://doi.org/10.1084/jem.20071681
Autor:
Charles S. Carter, Hua Zhang, Margaret V. Brown, Brenna J. Hill, Daniel C. Douek, Thomas A. Fleisher, Lauren M. Long, Jay A. Berzofsky, Martin Guimond, Donna Bernstein, Elizabeth J. Read, Kevin S. Chua, Veena Kapoor, Crystal L. Mackall, Lee J. Helman
Publikováno v:
Nature Medicine. 11:1238-1243
CD4(+)CD25(+) regulatory T (T(reg)) cells have a crucial role in maintaining immune tolerance. Mice and humans born lacking T(reg) cells develop severe autoimmune disease, and depletion of T(reg) cells in lymphopenic mice induces autoimmunity. Interl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0787a5bee1533246b56a9c2650ea983
https://doi.org/10.1038/nm1312
https://doi.org/10.1038/nm1312
Autor:
Jeffrey A. Toretsky, Elaine K. Thomas, Jeffrey Summers, Melinda S. Merchant, Yvona Ward, Crystal L. Mackall, Chand Khanna, Lee J. Helman, Hua Zhang, Carl H. June, Bill Telford, Kevin S. Chua
Publikováno v:
Cancer Biology & Therapy. 2:579-586
Inadequate costimulation by solid tumors is generally believed to induce immune tolerance during primary tumor growth. We looked for tumor-specific immunity vs. tolerance in patients with Ewing's sarcoma. Circulating T cells from patients with progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3c13f29e7e266d658b49f8b0db1073
https://doi.org/10.4161/cbt.2.5.545
https://doi.org/10.4161/cbt.2.5.545
Publikováno v:
Molecular Medicine. 8:405-416
Identification of differentially expressed genes between normal and diseased states is an area of intense current medical research that can lead to the discovery of new therapeutic targets. However, isolation of differentially expressed genes by subt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d703792814975b8e2c3d12a777c0fb1
https://doi.org/10.1007/bf03402021
https://doi.org/10.1007/bf03402021
Autor:
David E. Nelson, Donn M. Stewart, Kevin S. Chua, Susan C. Weir, Warren Strober, Brenda A. Cuccherini, Betty B. Wray, Vee J. Gill, Ivan J. Fuss
Publikováno v:
Clinical Immunology. 97:121-129
Two patients with Bruton's X-linked agammaglobulinemia are described with bacteremia and skin/bone infection due to an organism which by 16S rRNA gene sequence analysis was most closely related to "Flexispira" rappini (and thus designated a Flexispir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f245b0e2c8a2d9692ee7ca4cb00855fc
https://doi.org/10.1006/clim.2000.4932
https://doi.org/10.1006/clim.2000.4932
Publikováno v:
The Journal of Immunology. 165:691-702
In the present study, we show that human self-MHC-reactive (autoreactive) T cell clones are functionally distinct from Ag-specific T cell clones. Self-MHC-reactive T cells exhibited helper function for B cell Ig production when cultured with non-T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c06ae8af2b69f4d695fcefb5768a4a1
https://doi.org/10.4049/jimmunol.165.2.691
https://doi.org/10.4049/jimmunol.165.2.691
Autor:
Warren Strober, Kevin S. Chua
Publikováno v:
Clinical Reviews in Allergy & Immunology. 19:157-182
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de49c53cbceb0efff9660ea5f936ff80
https://doi.org/10.1385/criai:19:2:157
https://doi.org/10.1385/criai:19:2:157
Autor:
Björn R. Lúdvíksson, Michael C. Sneller, Kevin S. Chua, Cheryl Talar-Williams, Carol A. Langford, Rolf O. Ehrhardt, Anthony S. Fauci, Warren Strober
Publikováno v:
The Journal of Immunology. 160:3602-3609
Wegener’s granulomatosis (WG) is a granulomatous vasculitis that affects the upper respiratory tract, lung, and kidney. Since T cells make up a significant proportion of cells infiltrating granulomatous lesions in WG, we investigated the proliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fec551a0407782b84c051c0bb8963ec
https://doi.org/10.4049/jimmunol.160.7.3602
https://doi.org/10.4049/jimmunol.160.7.3602
Publikováno v:
Current Protocols in Immunology
This unit describes procedures for the isolation of pure human B cell populations. Two broad approaches to the isolation of pure human B cell populations are available, one based on techniques of negative selection and the other using positive select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9bb6be1c9efef0d763dd56f69c2fb7
https://doi.org/10.1002/0471142735.im0705s49
https://doi.org/10.1002/0471142735.im0705s49