Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kevin S. Cadman"'
Autor:
Irene K. Moore, Gerald I. Shulman, Raynald Bergeron, Marc Pypaert, Jian Ming Ren, Kevin S. Cadman, Pascale Perret, Lawrence H. Young, Clay F. Semenkovich
Publikováno v:
ResearcherID
Scopus-Elsevier
Scopus-Elsevier
The underlying mechanism by which skeletal muscle adapts to exercise training or chronic energy deprivation is largely unknown. To examine this question, rats were fed for 9 wk either with or without beta-guanadinopropionic acid (beta-GPA; 1% enriche
Autor:
Sylvie Dufour, Gerald I. Shulman, Bradford B. Lowell, Antonio Vidal-Puig, Gary W. Cline, Kevin S. Cadman
Publikováno v:
Journal of Biological Chemistry. 276:20240-20244
To clarify the role of uncoupling protein-3 (UCP3) in skeletal muscle, we used NMR and isotopic labeling experiments to evaluate the effect of UCP3 knockout (UCP3KO) in mice on the regulation of energy metabolism in vivo. Whole body energy expenditur
Autor:
Kevin S. Cadman, Sylvie Dufour, Beat M. Jucker, Gerald I. Shulman, Xueying Cao, Jian-Ming Ren, Stephen F. Previs
Publikováno v:
Journal of Biological Chemistry. 275:39279-39286
To examine the relationship between mitochondrial energy coupling in skeletal muscle and change in uncoupling protein 3 (UCP3) expression during the transition from the fed to fasted state, we used a novel noninvasive31P/13C NMR spectroscopic approac
Autor:
Kevin S. Cadman, Xueying Cao, Jian-Ming Ren, Beat M. Jucker, Sylvie Dufour, Stephen F. Previs, Gerald I. Shulman, Brian Underhill
Publikováno v:
Proceedings of the National Academy of Sciences. 97:6880-6884
The recently cloned uncoupling protein homolog UCP3 is expressed primarily in muscle and therefore may play a significant role in the regulation of energy expenditure and body weight. However, investigation into the regulation of uncoupling protein h
Publikováno v:
Analytical Letters. 23:327-334
Toremifene is a triphenylethylene derivatiye that is currently undergoing Phase I-III clinical trials for antineoplastic activity. Toremifene has also shown chemosensitizing activity in multidrug resistant cancer cells. In the present study, we devel