Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kevin S Quackenbush"'
Autor:
Wells A. Messersmith, S. Gail Eckhardt, Todd M. Pitts, Peter J. Klauck, Patrick Blatchford, Anna Schreiber, Anna Capasso, Kevin S. Quackenbush, Jon Vogel, Andrew Thorburn, Jihye Kim, Anna Nguyen, Natalie J. Serkova, Kendra M. Huber, Rachel Yahn, Stacey M. Bagby, John J. Arcaroli, Aaron J. Scott
Antiangiogenic therapy used in treatment of metastatic colorectal cancer (mCRC) inevitably succumbs to treatment resistance. Upregulation of MET may play an essential role to acquired anti-VEGF resistance. We previously reported that cabozantinib (XL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2901411ba1d0779aad0f2ab3513c5b
https://doi.org/10.1158/1535-7163.c.6537727
https://doi.org/10.1158/1535-7163.c.6537727
Autor:
Wells A. Messersmith, S. Gail Eckhardt, Todd M. Pitts, Peter J. Klauck, Patrick Blatchford, Anna Schreiber, Anna Capasso, Kevin S. Quackenbush, Jon Vogel, Andrew Thorburn, Jihye Kim, Anna Nguyen, Natalie J. Serkova, Kendra M. Huber, Rachel Yahn, Stacey M. Bagby, John J. Arcaroli, Aaron J. Scott
Supplemental Table 1: Molecular and clinical characteristics of the 10 CRC explants used in the PDX model experiments. Seven explants have a KRAS mutation, 4 have a PIK3CA mutation, and none have a BRAF mutation. Over half of the explants came from p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c5260adec71ec4848d8b88d07f1ac2
https://doi.org/10.1158/1535-7163.22504408.v1
https://doi.org/10.1158/1535-7163.22504408.v1
Autor:
Wells A. Messersmith, S. Gail Eckhardt, Arvind Dasari, Basel M. Touban, Jaclyn M. Reinemann, Aik Choon Tan, Lynne Bemis, Marileila Varella-Garcia, Anna Spreafico, Todd M. Pitts, Rebecca W. Powell, Kevin S. Quackenbush, John J. Arcaroli
Purpose: Dysregulation of the phosphoinositide 3-kinase (PI3K) and Src signaling pathways commonly occur in colorectal cancer. Mutations in the PIK3CA gene are associated with an increase in severity of disease and worse clinical outcomes. Elevated l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22e136d980a35f10bdb34a61691c6bf
https://doi.org/10.1158/1078-0432.c.6520746
https://doi.org/10.1158/1078-0432.c.6520746
Autor:
Wells A. Messersmith, S. Gail Eckhardt, Arvind Dasari, Basel M. Touban, Jaclyn M. Reinemann, Aik Choon Tan, Lynne Bemis, Marileila Varella-Garcia, Anna Spreafico, Todd M. Pitts, Rebecca W. Powell, Kevin S. Quackenbush, John J. Arcaroli
PDF file - 295K, The effects of saracatinib on proliferation of CRC cell lines. Twenty-three CRC cell lines were treated with saracatinib (0.0625 um uM) and assayed by SRB 72 hours after exposure to drug. Cell lines (H508, LS180 and LS174T) with an I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088ccc34e206e12cb541d1a1b5653f15
https://doi.org/10.1158/1078-0432.22446411
https://doi.org/10.1158/1078-0432.22446411
Autor:
Aaron J Scott, Eun-Kee Song, Stacey Bagby, Alicia Purkey, Martin McCarter, Csaba Gajdos, Kevin S Quackenbush, Benjamin Cross, Todd M Pitts, Aik Choon Tan, S Gail Eckhardt, Hubert Fenton, John Arcaroli, Wells A Messersmith
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187173 (2017)
Dysregulation of the Src pathway has been shown to be important at various stages of cancer. Dasatinib is a potent Src/Abl inhibitor and has demonstrated to have anti-proliferative and anti-invasive activity in many preclinical models. The objective
Externí odkaz:
https://doaj.org/article/ffa9c06bfd5b415295825fb53b2a273e
Autor:
John J, Arcaroli, W M, Tai, Ryan, McWilliams, Stacey, Bagby, Patrick J, Blatchford, Marileila, Varella-Garcia, Alicia, Purkey, Kevin S, Quackenbush, Eun-Kee, Song, Todd M, Pitts, Dexiang, Gao, Chris, Lieu, Martine, McManus, Aik Choon, Tan, Xianxian, Zheng, Qin, Zhang, Mark, Ozeck, Peter, Olson, Zhi-Qin, Jiang, Scott, Kopetz, Antonio, Jimeno, Stephen, Keysar, Gail, Eckhardt, Wells A, Messersmith
Publikováno v:
International journal of cancer. 138(1)
Dysregulation of the Notch1 receptor has been shown to facilitate the development and progression of colorectal cancer (CRC) and has been identified as an independent predictor of disease progression and worse survival. Although mutations in the NOTC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fba2dc296e13638d1a2a28fd497d9c26
https://pubmed.ncbi.nlm.nih.gov/26152787
https://pubmed.ncbi.nlm.nih.gov/26152787
Autor:
Eun-Kee, Song, W M, Tai, Wells A, Messersmith, Stacey, Bagby, Alicia, Purkey, Kevin S, Quackenbush, Todd M, Pitts, Guoliang, Wang, Patrick, Blatchford, Rachel, Yahn, Jeffrey, Kaplan, Aik Choon, Tan, Chloe E, Atreya, Gail, Eckhardt, Robin K, Kelley, Alan, Venook, Eunice L, Kwak, David, Ryan, John J, Arcaroli
Publikováno v:
International journal of cancer. 136(8)
Antiangiogenic therapy is commonly used for the treatment of colorectal cancer (CRC). Although patients derive some clinical benefit, treatment resistance inevitably occurs. The MET signaling pathway has been proposed to be a major contributor of res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2b1950665446ff667fabe2154c9344f
https://pubmed.ncbi.nlm.nih.gov/25242168
https://pubmed.ncbi.nlm.nih.gov/25242168
Autor:
Scott, Aaron J.1 ajscott@email.arizona.edu, Song, Eun-Kee2, Bagby, Stacey3, Purkey, Alicia3, McCarter, Martin4, Gajdos, Csaba4, Quackenbush, Kevin S.3, Cross, Benjamin3, Pitts, Todd M.3, Tan, Aik Choon3, Eckhardt, S. Gail5, Fenton, Hubert6, Arcaroli, John3, Messersmith, Wells A.3
Publikováno v:
PLoS ONE. 11/01/2017, Vol. 12 Issue 11, p1-14. 14p.
Autor:
Arcaroli, John J., Tai, W.M., McWilliams, Ryan, Bagby, Stacey, Blatchford, Patrick J., Varella ‐ Garcia, Marileila, Purkey, Alicia, Quackenbush, Kevin S., Song, Eun ‐ Kee, Pitts, Todd M., Gao, Dexiang, Lieu, Chris, McManus, Martine, Tan, Aik Choon, Zheng, Xianxian, Zhang, Qin, Ozeck, Mark, Olson, Peter, Jiang, Zhi ‐ Qin, Kopetz, Scott
Publikováno v:
International Journal of Cancer; Jan2016, Vol. 138 Issue 1, p195-205, 11p
Autor:
Surendra Singh, Arcaroli, John J., Orlicky, David J., Ying Chen, Messersmith, Wells A., Bagby, Stacey, Purkey, Alicia, Quackenbush, Kevin S., Thompson, David C., Vasiliou, Vasilis
Publikováno v:
Pancreas; Jan2016, Vol. 45 Issue 1, p117-122, 6p