Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kevin S Edgar"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Dysregulation of nitric oxide (NO) production can cause ischaemic retinal injury and result in blindness. How this dysregulation occurs is poorly understood but thought to be due to an impairment in NO synthase function (NOS) and nitro-oxida
Externí odkaz:
https://doaj.org/article/17360d8065aa40858299d7f9800c1b56
Autor:
Shun Hay Pun, Karla M. O’Neill, Kevin S. Edgar, Eleanor K. Gill, Arya Moez, Hojjat Naderi-Meshkin, Sudhir B. Malla, Michelle B. Hookham, Mohammed Alsaggaf, Vinuthna Vani Madishetti, Bianca Botezatu, William King, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Derek P. Brazil, Reinhold J. Medina, Chris J. Watson, David J. Grieve
Publikováno v:
Cells, Vol 12, Iss 18, p 2220 (2023)
Ischaemic cardiovascular disease is associated with tissue hypoxia as a significant determinant of angiogenic dysfunction and adverse remodelling. While cord blood-derived endothelial colony-forming cells (CB-ECFCs) hold clear therapeutic potential d
Externí odkaz:
https://doaj.org/article/c401b027209144cda01f2bdf818f87be
Autor:
Michael O’Hare, Gema Esquiva, Mary K. McGahon, Jose Manuel Romero Hombrebueno, Josy Augustine, Paul Canning, Kevin S. Edgar, Peter Barabas, Thomas Friedel, Patrizia Cincolà, Jennifer Henry, Katie Mayne, Hannah Ferrin, Alan W. Stitt, Timothy J. Lyons, Derek P. Brazil, David J. Grieve, J. Graham McGeown, Tim M. Curtis
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Loss of retinal blood flow autoregulation is an early feature of diabetes that precedes the development of clinically recognizable diabetic retinopathy (DR). Retinal blood flow autoregulation is mediated by the myogenic response of the retinal arteri
Externí odkaz:
https://doaj.org/article/a8eb7a938da94f0fbc793be40b8dc476
Autor:
Linan Xu, Fiachra Humphries, Nezira Delagic, Bingwei Wang, Ashling Holland, Kevin S. Edgar, Jose R. Hombrebueno, Donna Beer Stolz, Ewa Oleszycka, Aoife M. Rodgers, Nadezhda Glezeva, Kenneth McDonald, Chris J. Watson, Mark T. Ledwidge, Rebecca J. Ingram, David J. Grieve, Paul N. Moynagh
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) is a protein with roles in early development, activation of the transcription factor NF-κB, and production of mitochondrial reactive oxygen species (mROS) that facilitates clea
Externí odkaz:
https://doaj.org/article/0345bb89fc434b80b4c4d1233fd83303
Autor:
Gerard M. Walls, Mihaela Ghita, Rachel Queen, Kevin S. Edgar, Eleanor K. Gill, Refik Kuburas, David J. Grieve, Chris J. Watson, Alan McWilliam, Marcel Van Herk, Kaye J. Williams, Aidan J. Cole, Suneil Jain, Karl T. Butterworth
Publikováno v:
Walls, G M, Ghita, M, Queen, R, Edgar, K S, Gill, E K, Kuburas, R, Grieve, D J, Watson, C J, McWilliam, A, Van Herk, M, Williams, K J, Cole, A J, Jain, S & Butterworth, K T 2023, ' Spatial gene expression changes in the mouse heart after base-targeted irradiation ', International Journal of Radiation Oncology Biology Physics, vol. 115, no. 2, pp. 453-463 . https://doi.org/10.1016/j.ijrobp.2022.08.031
International Journal of Radiation Oncology Biology Physics, 115(2), 453-463. Elsevier Inc.
International Journal of Radiation Oncology Biology Physics, 115(2), 453-463. Elsevier Inc.
Purpose: Radiation cardiotoxicity (RC) is a clinically significant adverse effect of treatment for patients with thoracic malignancies. Clinical studies in lung cancer have indicated that heart substructures are not uniformly radiosensitive, and that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c322830095dcc79b6d9b7def15018c
https://pure.qub.ac.uk/en/publications/77fa0ddf-058e-46fb-aee7-76ef9cb31b55
https://pure.qub.ac.uk/en/publications/77fa0ddf-058e-46fb-aee7-76ef9cb31b55
Autor:
David J. Grieve, Mark Ledwidge, Kevin S Edgar, B Collins, Patrick Collier, Kenneth McDonald, Christopher A. Watson, Claire Tonry, Christine S. Moravec
Publikováno v:
General posters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7148d5fef4ffe2be8d8b91cde498fa74
https://doi.org/10.1136/heartjnl-2021-ics.41
https://doi.org/10.1136/heartjnl-2021-ics.41
Autor:
Michael O’Hare, Gema Esquiva, Mary K. McGahon, Jose Manuel Romero Hombrebueno, Josy Augustine, Paul Canning, Kevin S. Edgar, Peter Barabas, Thomas Friedel, Patrizia Cincolà, Jennifer Henry, Katie Mayne, Hannah Ferrin, Alan W. Stitt, Timothy J. Lyons, Derek P. Brazil, David J. Grieve, J. Graham McGeown, Tim M. Curtis
Publikováno v:
O'Hare, M, Esquiva, G, McGahon, M K, Hombrebueno, J M R, Augustine, J, Canning, P, Edgar, K S, Barabas, P, Friedel, T, Cincolà, P, Henry, J, Mayne, K, Ferrin, H, Stitt, A W, Lyons, T J, Brazil, D P, Grieve, D J, McGeown, J G & Curtis, T M 2022, ' Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats ', JCI insight, vol. 7, no. 18, e155128 . https://doi.org/10.1172/jci.insight.155128
Loss of retinal blood flow autoregulation is an early feature of diabetes that precedes the development of clinically recognizable diabetic retinopathy (DR). Retinal blood flow autoregulation is mediated by the myogenic response of the retinal arteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e026e1b17c412483c93ec37feda6a413
https://pubmed.ncbi.nlm.nih.gov/36134661
https://pubmed.ncbi.nlm.nih.gov/36134661
Autor:
Aoife M. Rodgers, Ewa Oleszycka, Kevin S Edgar, Kenneth McDonald, Chris Watson, Jose R. Hombrebueno, Linan Xu, Paul N. Moynagh, Ashling Holland, Mark Ledwidge, David J. Grieve, Rebecca J. Ingram, Nadezhda Glezeva, Fiachra Humphries, Nezira Delagic, Bingwei Wang, Donna B. Stolz
Publikováno v:
Xu, L, Humphries, F, Delagic, N, Wang, B, Holland, A, Edgar, K S, Hombrebueno, J R, Stolz, D B, Oleszycka, E, Rodgers, A M, Glezeva, N, McDonald, K, Watson, C J, Ledwidge, M T, Ingram, R J, Grieve, D J & Moynagh, P N 2021, ' ECSIT is a critical limiting factor for cardiac function ', JCI insight, vol. 6, no. 12, e142801 . https://doi.org/10.1172/jci.insight.142801
JCI Insight
JCI Insight
Evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) is a protein with roles in early development, activation of the transcription factor NF-κB, and production of mitochondrial reactive oxygen species (mROS) that facilitates clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfeef42f1038b41ab2881b39ebdd595
https://pure.qub.ac.uk/en/publications/87c025e6-1960-482c-8e49-138c25174aa6
https://pure.qub.ac.uk/en/publications/87c025e6-1960-482c-8e49-138c25174aa6
Autor:
David J. Grieve, S. Lisgo, Chris J Watson, Kevin S Edgar, M. van Herk, R. Queen, Gerard Walls, Kaye J. Williams, Karl T. Butterworth, Aidan J Cole, Suneil Jain, L. Overman, Eleanor K Gill, Mihaela Ghita, Alan McWilliam
Publikováno v:
Radiotherapy and Oncology. 161:S336-S337
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45063fd43230301fc61ce206d08c854d
https://doi.org/10.1016/s0167-8140(21)07328-x
https://doi.org/10.1016/s0167-8140(21)07328-x
Autor:
Kevin S Edgar, David J. Grieve, Fiona L. Wilkinson, Marta Vilà González, Aleksandar Ivetic, Chunbo Yang, Thomas Morrison, Andrew Yacoub, Alan W. Stitt, Andriana Margariti, Arya Moez, Sophia Kelaini, Lingfang Zeng, Nicola C. Edwards, Rachel Caines, Magdalini Eleftheriadou, Noemi Lois, Anna Zampetaki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Yang, C, Eleftheriadou, M, Kelaini, S, Morrison, T, González, M V, Caines, R, Edwards, N, Yacoub, A, Edgar, K, Moez, A, Ivetic, A, Zampetaki, A, Zeng, L, Wilkinson, F L, Lois, N, Stitt, A W, Grieve, D J & Margariti, A 2020, ' Targeting QKI-7 in vivo restores endothelial cell function in diabetes ', Nature Communications, vol. 11, no. 1, 3812 . https://doi.org/10.1038/s41467-020-17468-y
Nature Communications
Yang, C, Eleftheriadou, M, Kelaini, S, Morrison, T, González, M V, Caines, R, Edwards, N, Yacoub, A, Edgar, K, Moez, A, Ivetic, A, Zampetaki, A, Zeng, L, Wilkinson, F L, Lois, N, Stitt, A W, Grieve, D J & Margariti, A 2020, ' Targeting QKI-7 in vivo restores endothelial cell function in diabetes ', Nature Communications, vol. 11, no. 1, 3812 . https://doi.org/10.1038/s41467-020-17468-y
Nature Communications
Vascular endothelial cell (EC) dysfunction plays a key role in diabetic complications. This study discovers significant upregulation of Quaking-7 (QKI-7) in iPS cell-derived ECs when exposed to hyperglycemia, and in human iPS-ECs from diabetic patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d63bd09de83a23024811829eb558c7
https://doi.org/10.1038/s41467-020-17468-y
https://doi.org/10.1038/s41467-020-17468-y