From bead to flask: Synthesis of a complex β-amido-amide for probe-development studies

Autor: Kevin S. Martin, Cristian Soldi, Kellan N. Candee, Hiromi I. Wettersten, Robert H. Weiss, Jared T. Shaw

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 260-264 (2013)

A concise synthesis of benzimidazole-substituted β-amido-amide LLW62 is presented. The original synthesis of compounds related to LLW62 was developed on Rink resin as part of a “one-bead, one-compound” combinatorial approach for on-bead screenin

Externí odkaz: https://doaj.org/article/4641161af21f49e59a27eff44a39146d

RNase I regulates

Autor: Benjamin M, Fontaine, Kevin S, Martin, Jennifer M, Garcia-Rodriguez, Claire, Jung, Laura, Briggs, Jessica E, Southwell, Xin, Jia, Emily E, Weinert

Publikováno v: The Biochemical journal. 475(8)

Regulation of nucleotide and nucleoside concentrations is critical for faithful DNA replication, transcription, and translation in all organisms, and has been linked to bacterial biofilm formation. Unusual 2’,3’-cyclic nucleotide monophosphates (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf5315218ea3ace0307360f58edf85c1
https://pubmed.ncbi.nlm.nih.gov/29555843

From bead to flask: Synthesis of a complex β-amido-amide for probe-development studies

Autor: Hiromi I. Wettersten, Jared T. Shaw, Kellan N Candee, Robert H. Weiss, Cristian Soldi, Kevin S. Martin

Publikováno v: Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 260-264 (2013)

A concise synthesis of benzimidazole-substituted β-amido-amide LLW62 is presented. The original synthesis of compounds related to LLW62 was developed on Rink resin as part of a “one-bead, one-compound” combinatorial approach for on-bead screenin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9be24232b6fbec98dd0b29ba89a5fa4
http://europepmc.org/articles/PMC3566855

Synthesis and evaluation of quinazolines as inhibitors of the bacterial cell division protein FtsZ

Autor: Jared T. Moore, Valerie Huynh, Kevin S. Martin, Terrence E. O’Brien, Zi Yao, David E. Anderson, James B. Ames, Clarissa Tadeus, Luiz A. E. Pollo, Gabriella M. Nepomuceno, Katie M. Chan, Jared T. Shaw, Francisco J. Sarabia

Publikováno v: Nepomuceno, GM; Chan, KM; Huynh, V; Martin, KS; Moore, JT; Obrien, TE; et al.(2015). Synthesis and evaluation of quinazolines as inhibitors of the bacterial cell division protein FtsZ. ACS Medicinal Chemistry Letters, 6(3), 308-312. doi: 10.1021/ml500497s. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6098r49t
ACS medicinal chemistry letters, vol 6, iss 3

© 2015 American Chemical Society. The bacterial cell division protein FtsZ is one of many potential targets for the development of novel antibiotics. Recently, zantrin Z3 was shown to be a cross-species inhibitor of FtsZ; however, its specific inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b7f6c96d5df05f51f3161cfc88afd1
http://www.escholarship.org/uc/item/6098r49t

Ammonia synthons for the multicomponent assembly of complex gamma-lactams

Autor: Darlene Q. Tan, Kevin S. Martin, Jared T. Shaw, James C. Fettinger

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 108(17)

The synthesis of γ-lactams that are unsubstituted at the 1-position (nitrogen) as well as their subsequent N -functionalization is reported. A recently discovered four-component reaction (4CR) is employed with either an ammonia precursor or a protec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308c0f3e22984daf249c0a68215f79c5
https://pubmed.ncbi.nlm.nih.gov/21289284