Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Kevin S, Harrod"'
Autor:
Michael John Patton, Carlos J. Orihuela, Kevin S. Harrod, Mohammad A. N. Bhuiyan, Paari Dominic, Christopher G. Kevil, Daniel Fort, Vincent X. Liu, Maha Farhat, Jonathan L. Koff, Charitharth V. Lal, Anuj Gaggar, Robert P. Richter, Nathaniel Erdmann, Matthew Might, Amit Gaggar
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background Recent single-center reports have suggested that community-acquired bacteremic co-infection in the context of Coronavirus disease 2019 (COVID-19) may be an important driver of mortality; however, these reports have not been valida
Externí odkaz:
https://doaj.org/article/08100dfe0b7b44c1ad101bf1bafeb813
Autor:
Erin Y. Earnhardt, Jennifer L. Tipper, Adonis D’Mello, Ming-Yuan Jian, Elijah S. Conway, James A. Mobley, Carlos J. Orihuela, Hervé Tettelin, Kevin S. Harrod
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Influenza A virus (IAV) infection is commonly complicated by secondary bacterial infections that lead to increased morbidity and mortality. Our recent work demonstrates that IAV disrupts airway homeostasis, leading to airway pathophysiology resemblin
Externí odkaz:
https://doaj.org/article/7e87c160e938464ba226cadb630cb6cf
Autor:
Camilla Margaroli, Timothy Fram, Nirmal S. Sharma, Siddharth B. Patel, Jennifer Tipper, Sarah W. Robison, Derek W. Russell, Seth D. Fortmann, Mudassir M. Banday, Yixel Soto-Vazquez, Tarek Abdalla, Sawanan Saitornuang, Matthew C. Madison, Sixto M. Leal Jr., Kevin S. Harrod, Nathaniel B. Erdmann, Amit Gaggar
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Neutrophilic inflammation characterizes several respiratory viral infections, including COVID-19–related acute respiratory distress syndrome, although its contribution to disease pathogenesis remains poorly understood. Blood and airway immune cells
Externí odkaz:
https://doaj.org/article/99e6187f08e34f4d83544380537612d3
Autor:
Qian Li, Kadambari Vijaykumar, Scott E. Phillips, Shah S. Hussain, Nha V. Huynh, Courtney M. Fernandez-Petty, Jacelyn E. Peabody Lever, Jeremy B. Foote, Janna Ren, Javier Campos-Gómez, Farah Abou Daya, Nathaniel W. Hubbs, Harrison Kim, Ezinwanne Onuoha, Evan R. Boitet, Lianwu Fu, Hui Min Leung, Linhui Yu, Thomas W. Detchemendy, Levi T. Schaefers, Jennifer L. Tipper, Lloyd J. Edwards, Sixto M. Leal Jr., Kevin S. Harrod, Guillermo J. Tearney, Steven M. Rowe
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Substantial clinical evidence supports the notion that ciliary function in the airways is important in COVID-19 pathogenesis. Although ciliary damage has been observed in both in vitro and in vivo models, the extent or nature of impairment of mucocil
Externí odkaz:
https://doaj.org/article/0c708e5e467241419dc7f4ebe99420b0
Autor:
Michael D. Schultz, John J. Suschak, Davide Botta, Aaron Silva-Sanchez, R. Glenn King, Thomas W. Detchemendy, Chetan D. Meshram, Jeremy B. Foote, Fen Zhou, Jennifer L. Tipper, Jianfeng Zhang, Kevin S. Harrod, Sixto M. Leal, Troy D. Randall, M. Scot Roberts, Bertrand Georges, Frances E. Lund
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 6 (2022)
The coronavirus disease 2019 (COVID-19) pandemic has illustrated the critical need for effective prophylactic vaccination to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Intranasal vaccination is an attractive a
Externí odkaz:
https://doaj.org/article/bce98486f913451b8115f9d51ef70aaa
Autor:
Raymond J. Langley, Marie E. Migaud, Lori Flores, J. Will Thompson, Elizabeth A. Kean, Murphy M. Mostellar, Matthew Mowry, Patrick Luckett, Lina D. Purcell, James Lovato, Sheetal Gandotra, Ryan Benton, D. Clark Files, Kevin S. Harrod, Mark N. Gillespie, Peter E. Morris
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Acute respiratory failure (ARF) requiring mechanical ventilation, a complicating factor in sepsis and other disorders, is associated with high morbidity and mortality. Despite its severity and prevalence, treatment options are limited. In li
Externí odkaz:
https://doaj.org/article/ebfe182cebd342acb30834ed1318f664
Autor:
Norberto Gonzalez-Juarbe, Ashleigh N. Riegler, Alexander S. Jureka, Ryan P. Gilley, Jeffrey D. Brand, John E. Trombley, Ninecia R. Scott, Maryann P. Platt, Peter H. Dube, Chad M. Petit, Kevin S. Harrod, Carlos J. Orihuela
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108062- (2020)
Summary: Pneumonias caused by influenza A virus (IAV) co- and secondary bacterial infections are characterized by their severity and high mortality rate. Previously, we have shown that bacterial pore-forming toxin (PFT)-mediated necroptosis is a key
Externí odkaz:
https://doaj.org/article/b804d5f73aa147ecb872b34cc558199e
Autor:
R. Glenn King, Aaron Silva-Sanchez, Jessica N. Peel, Davide Botta, Alexandria M. Dickson, Amelia K. Pinto, Selene Meza-Perez, S. Rameeza Allie, Michael D. Schultz, Mingyong Liu, John E. Bradley, Shihong Qiu, Guang Yang, Fen Zhou, Esther Zumaquero, Thomas S. Simpler, Betty Mousseau, John T. Killian, Brittany Dean, Qiao Shang, Jennifer L. Tipper, Christopher A. Risley, Kevin S. Harrod, Tsungwei Feng, Young Lee, Bethlehem Shiberu, Vyjayanthi Krishnan, Isabelle Peguillet, Jianfeng Zhang, Todd J. Green, Troy D. Randall, John J. Suschak, Bertrand Georges, James D. Brien, Frances E. Lund, M. Scot Roberts
Publikováno v:
Vaccines, Vol 9, Iss 8, p 881 (2021)
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Intranasal vaccination is an attractive str
Externí odkaz:
https://doaj.org/article/2c3ec67e167b48a7a637b11e247315c6
Autor:
Seth D. Fortmann, Michael Patton, Blake F. Frey, Jennifer L. Tipper, Sivani B. Reddy, Cristiano P. Vieira, Vidya Sagar Hanumanthu, Sarah Sterrett, Jason L. Floyd, Ram Prasad, Jeremy D. Zucker, Andrew B. Crouse, Forest Huls, Rati Chkheidze, Peng Li, Nathaniel Erdmann, Kevin S. Harrod, Amit Gaggar, Paul A Goepfert, Maria B. Grant, Matthew Might
Publikováno v:
Blood Advances.
Several independent lines of evidence suggest that megakaryocytes are dysfunctional in severe COVID-19. Herein, we characterized peripheral circulating megakaryocytes in a large cohort of COVID-19 inpatients and correlated subpopulation frequencies w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::831f96b221f8939307965386f4a00c68
https://doi.org/10.1182/bloodadvances.2022009022
https://doi.org/10.1182/bloodadvances.2022009022
Mucociliary Clearance Augmenting Drugs Block SARS-Cov-2 Replication in Human Airway Epithelial Cells
Autor:
Javier Campos-Gómez, Courtney Fernandez Petty, Marina Mazur, Liping Tang, George M. Solomon, Reny Joseph, Qian Li, Jacelyn E. Peabody Lever, Shah Saddad Hussain, Kevin S. Harrod, Ezinwanne E. Onuoha, Harrison Kim, Steven M. Rowe
The coronavirus disease (COVID-19) pandemic, caused by SARS-CoV-2 coronavirus, is devastatingly impacting human health. A prominent component of COVID-19 is the infection and destruction of the ciliated respiratory cells, which perpetuates disseminat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e978738dc2431903db7e94f8af64606c
https://doi.org/10.1101/2023.01.30.526308
https://doi.org/10.1101/2023.01.30.526308
