Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Kevin Rouault‐Pierre"'
Autor:
Keith Woodley, Laura S. Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M. Rattigan, Céline Philippe, Vilma Dembitz, Aoife M. S. Magee, Ryan Asby, Louie N. van de Lagemaat, Christopher Mapperley, Sophie C. James, Jochen H. M. Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S. Vassiliou, Kamil R. Kranc, G. Vignir Helgason, Brian J. P. Huntly, Paolo Gallipoli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phospha
Externí odkaz:
https://doaj.org/article/a02c0de22e004847b729037f65f8b163
Autor:
Pedro Casado, Ana Rio-Machin, Juho J. Miettinen, Findlay Bewicke-Copley, Kevin Rouault-Pierre, Szilvia Krizsan, Alun Parsons, Vinothini Rajeeve, Farideh Miraki-Moud, David C. Taussig, Csaba Bödör, John Gribben, Caroline Heckman, Jude Fitzgibbon, Pedro R. Cutillas
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Acute myeloid leukaemia (AML) patients harbouring certain chromosome abnormalities have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular lands
Externí odkaz:
https://doaj.org/article/5e487f8d5d7f4d8e866dad9751eee848
Autor:
Nerea Berastegui, Marina Ainciburu, Juan P. Romero, Paula Garcia-Olloqui, Ana Alfonso-Pierola, Céline Philippe, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Raquel Ruiz-Hernández, Ander Abarrategi, Raquel Ordoñez, Diego Alignani, Sarai Sarvide, Laura Castro-Labrador, José M. Lamo-Espinosa, Mikel San-Julian, Tamara Jimenez, Félix López-Cadenas, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Maria Julia Montoro, Bárbara Tazón, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Mikel Hernaez, Sofía Huerga, Findlay Bewicke-Copley, Ana Rio-Machin, Matthew T. Maurano, María Díez-Campelo, David Valcarcel, Kevin Rouault-Pierre, David Lara-Astiaso, Teresa Ezponda, Felipe Prosper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Myelodysplastic syndromes (MDS) are age-related pathologies in which alterations of hematopoietic stem cells lead to abnormal formation of blood cells. Here, the authors study the lesions that these cells undergo in aging and disease, characterizing
Externí odkaz:
https://doaj.org/article/5a52f5ed769d4553afa3673e2f1e7052
Autor:
Kevin Rouault-Pierre
Publikováno v:
HemaSphere, Vol 5, Iss 6, p e587 (2021)
Externí odkaz:
https://doaj.org/article/e3f2df2cd4184235b2ca231fbf50d334
Autor:
Alessandro Di Tullio, Kevin Rouault-Pierre, Ander Abarrategi, Syed Mian, William Grey, John Gribben, Aengus Stewart, Elizabeth Blackwood, Dominique Bonnet
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Overriding cytarabine resistance in AML remains an unmet medical need. Here, the authors show that the CHK1 inhibitor GDC-0575 in combination with cytarabine and G-CSF has a significant anti-leukemic effect without toxicity to normal marrow stem and
Externí odkaz:
https://doaj.org/article/77ff00f53b1049f3aa2acb231a637d78
Autor:
Alessandro Di Tullio, Diana Passaro, Kevin Rouault-Pierre, Sukhveer Purewal, Dominique Bonnet
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 5-11 (2017)
Nuclear factor erythroid-derived 2 (NF-E2) has been associated with megakaryocyte maturation and platelet production. Recently, an increased in NF-E2 activity has been implicated in myeloproliferative neoplasms. Here, we investigate the role of NF-E2
Externí odkaz:
https://doaj.org/article/588c47c8a4ee4072ba0f0e2f7bbd7dcd
Autor:
Kelly Féral, Manon Jaud, Céline Philippe, Doriana Di Bella, Stéphane Pyronnet, Kevin Rouault-Pierre, Laurent Mazzolini, Christian Touriol
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 199 (2021)
The unfolded protein response (UPR) is an evolutionarily conserved adaptive signaling pathway triggered by a stress of the endoplasmic reticulum (ER) lumen compartment, which is initiated by the accumulation of unfolded proteins. This response, media
Externí odkaz:
https://doaj.org/article/bf780cdca8b94f51bcd35c5a9f3864ba
Autor:
Katie Foster, François Lassailly, Fernando Anjos-Afonso, Erin Currie, Kevin Rouault-Pierre, Dominique Bonnet
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 690-701 (2015)
Despite advances in our understanding of interactions between mouse hematopoietic stem cells (HSCs) and their niche, little is known about communication between human HSCs and the microenvironment. Using a xenotransplantation model and intravital ima
Externí odkaz:
https://doaj.org/article/6970d5d7f0ca4961b38cca890915baad
Autor:
Manon Jaud, Céline Philippe, Doriana Di Bella, Weiwei Tang, Stéphane Pyronnet, Henrik Laurell, Laurent Mazzolini, Kevin Rouault-Pierre, Christian Touriol
Publikováno v:
Cells, Vol 9, Iss 3, p 540 (2020)
Abstract: During carcinogenesis, almost all the biological processes are modified in one way or another. Among these biological processes affected, anomalies in protein synthesis are common in cancers. Indeed, cancer cells are subjected to a wide ran
Externí odkaz:
https://doaj.org/article/1edb37d8249c421883474deb70bd2581
Autor:
Kevin Rouault-Pierre, Alexander E. Smith, Syed A. Mian, Irene Pizzitola, Austin G. Kulasekararaj, Ghulam J. Mufti, Dominique Bonnet
Publikováno v:
Haematologica, Vol 102, Iss 1 (2017)
Externí odkaz:
https://doaj.org/article/f22666fb1a324d30bcf97d2b9df28327