Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kevin Ronald Condroski"'
Autor:
Geoffrey R. Oxnard, Satoshi Yoda, Bruce G. Robinson, Eliana B. Gomez, Sarah-Jane Dawson, S. Michael Rothenberg, Justin F. Gainor, Dahlia Henry, Oliver Gautschi, Christine Khoo, Stephen Q. Wong, Edward Y. Zhu, Andrew T. Metcalf, Louis Stancato, Brian B. Tuch, Barbara J. Brandhuber, Steve Andrews, Jessica J. Lin, Lavinia Tan, Kevin Ronald Condroski, Vivek Subbiah, Lecia V. Sequist, Wayne Blosser, James F. Blake, Joshua Ballard, Kolakowski Gabrielle R, Kevin Ebata, Alexander Drilon, Benjamin Solomon, Michele Nguyen, Sebastian Hollizeck
Publikováno v:
Journal of Thoracic Oncology. 15:541-549
Introduction Novel rearranged in transfection (RET)-specific tyrosine kinase inhibitors (TKIs) such as selpercatinib (LOXO-292) have shown unprecedented efficacy in tumors positive for RET fusions or mutations, notably RET fusion-positive NSCLC and R
Autor:
Charles E. Mowbray, Kazuya Nagaoka, Sachiko Itono, Rina Kaki, Yafeng Cao, Hiromi Nakai, Kevin Ronald Condroski, Constantin Radu, Naoaki Watanabe, Garry Pairaudeau, Ieuan Roberts, Benjamin Ian Perry, Ola Engkvist, Yuichiro Akao, Chiaki Kimura, Osamu Yoshida, Ryu Yoshida, Thierry Kogej, Mitsuyuki Shimada, Akira Naito, David Shum, Huanxu Xie, Stacie S. Canan, Shuji Yonezawa
An innovative pre-competitive virtual screening collaboration was engaged to validate and subsequently explore an imidazo[1,2-a]pyridine screening hit for visceral leishmaniasis. In silico probing of five proprietary pharmaceutical company libraries
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eab07a33951ad2b661f896dbd891f48
https://doi.org/10.26434/chemrxiv.13134785.v1
https://doi.org/10.26434/chemrxiv.13134785.v1
Autor:
Kevin Ronald Condroski, Kolakowski Gabrielle R, Thomas C. Irvin, Nisha A. Patel, Manoj Kumar, Joshua Ballard, Erin D. Anderson, Andrews Steven W, Eliana B. Gomez, Barbara J. Brandhuber, Faith D. Watson
Publikováno v:
Cancer Research. 81:1464-1464
In May 2020, selpercatinib became the first FDA-approved selective RET inhibitor, indicated for patients (pts) with RET fusion-positive NSCLC and thyroid cancer as well as RET-mutant medullary thyroid cancer. Despite the durable activity of selpercat
Autor:
Kevin Ronald Condroski, Matt Hickman, Wei Liu, Laurie LeBrun, Gilles Carmel, Joshua Hansen, Gang Lu, Afshin Mahmoudi, Frans Baculi, Correa Matthew D, Tim Crea, Hon-Wah Man, George W. Muller, Chin-Chun Lu, Alexander L. Ruchelman, Fan Vocanson, Weihong Zhang
Publikováno v:
Journal of Medicinal Chemistry. 61:492-503
We previously disclosed the identification of cereblon modulator 3 (CC-885), with potent antitumor activity mediated through the degradation of GSPT1. We describe herein the structure–activity relationships for analogs of 3 with exploration of the
Autor:
Takashi Kohno, Steve Smith, Shingo Matsumoto, Barbara J. Brandhuber, Edward Y. Zhu, Michael Burkard, Kevin Ronald Condroski, Lauren Hanson, LouAnn Cable, Kevin Ebata, Lori J. Wirth, Hibiki Udagawa, Brian B. Tuch, S. Michael Rothenberg, Steve Andrews, Koichi Goto, Michele Nguyen, Genichiro Ishii, James F. Blake
Publikováno v:
JCO Precision Oncology
Autor:
Scott Alan Pratt, Patrice Lee, Thomas Daniel Aicher, John Fischer, Kevin Ronald Condroski, Brian R. Baer, Boyd Steven A, Mark D. Chicarelli, Walter C. Voegtli, Walter E. DeWolf, Francis X. Sullivan, Eli M. Wallace, Nickolas A. Neitzel, Lance A. Williams, Ronald Jay Hinklin, Turner Timothy M, Ajay Singh, Gary P. Hingorani, Michele Frank
Publikováno v:
Bioorganicmedicinal chemistry. 28(1)
Glucose flux through glucokinase (GK) controls insulin release from the pancreas in response to high levels of glucose. Flux through GK is also responsible for reducing hepatic glucose output. Since many individuals with type 2 diabetes appear to hav
Autor:
Xiaohui Peng, Rama K. Narla, Kevin Ronald Condroski, Nagy Mark A, John F. Boylan, Jennifer Riggs, Jan Elsner, Ashutosh A. Kulkarni, Dale Robinson, Kimberly Elizabeth Fultz, Dan Zhu, Tam Tran, Dan Cashion, Lida Tehrani, Katerina Leftheris, Laurie LeBrun, Barbra Pagarigan, Sogole Bahmanyar, Gustavo Fenalti
Publikováno v:
Journal of medicinal chemistry. 62(9)
Triple negative breast cancer (TNBC) is an aggressive disease with high relapse rates and few treatment options. Outlined in previous publications, we identified a series of potent, dual TTK/CLK2 inhibitors with strong efficacy in TNBC xenograft mode
Autor:
Kevin Ronald Condroski, Susan P. Rhodes, Maralee McVean, Walter C. Voegtli, Christopher F. Kraser, Walter E. DeWolf, Lance A. Williams, Deborah Anderson, Hillary L. Sturgis, Boyd Steven A, Ronald Jay Hinklin, Jonathan B. Houze, Brian R. Baer, Thomas Daniel Aicher
Publikováno v:
Journal of Medicinal Chemistry. 57:8180-8186
Glucokinase (GK) is the rate-limiting step for insulin release from the pancreas in response to high levels of glucose. Flux through GK also contributes to reducing hepatic glucose output. Since many individuals with type 2 diabetes appear to have an
Autor:
Ajay Singh, Lee Wai-Man, Kevin Ronald Condroski, Patrice Lee, Thomas Daniel Aicher, Laurie Thomas, Ronald Jay Hinklin, Boyd Steven A, Mark Joseph Chicarelli, Walter E. DeWolf, Lance Williams, Walter C. Voegtli
Publikováno v:
Journal of Medicinal Chemistry. 56:7669-7678
Glucose flux through glucokinase (GK) controls insulin release from the pancreas in response to high glucose concentrations. Glucose flux through GK also contributes to reducing hepatic glucose output. Because many individuals with type 2 diabetes ap
Autor:
Leonid Beigelman, Hailong Zhang, Benjamin T. Woodard, Christine Lemieux, Guy Vigers, Vlad Serebryany, Brad O. Buckman, Bin Wang, Scott D. Seiwert, Barbra J. Brandhuber, Steve Wenglowsky, Stengel Peter J, Andrews Steven W, Lawrence M. Blatt, Kennedy April L, Doherty George Andrew, John A. Josey, Joshua Ballard, Mary Geck Do, Madduru Machender R, Jiang Yutong, Kevin Ronald Condroski, Michael Lyon
Publikováno v:
Journal of Medicinal Chemistry. 57:1753-1769
HCV serine protease NS3 represents an attractive drug target because it is not only essential for viral replication but also implicated in the viral evasion of the host immune response pathway through direct cleavage of key proteins in the human inna