Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kevin Rhine"'
Autor:
Qishan Liang, Tao Yu, Eric Kofman, Pratibha Jagannatha, Kevin Rhine, Brian A. Yee, Kevin D. Corbett, Gene W. Yeo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract RNA-binding proteins (RBPs) have pivotal functions in RNA metabolism, but current methods are limited in retrieving RBP-RNA interactions within endogenous biological contexts. Here, we develop INSCRIBE (IN situ Sensitive Capture of RNA-prote
Externí odkaz:
https://doaj.org/article/83aaa86b265641a4b9aa06dd076b7a84
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Disordered RNA-binding proteins and repetitive RNA sequences are the main genetic causes of several neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington’s disease. Importantly, these components also seed the formation
Externí odkaz:
https://doaj.org/article/bd96e0d8abc64a928005bc18b7b48904
Autor:
Kevin Rhine, Sua Myong
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101131- (2022)
Summary: Liquid-liquid phase separation of intrinsically disordered proteins is known to underlie diverse pathologies such as neurodegeneration, cancer, and aging. The nucleation step of condensate formation is of critical importance for understandin
Externí odkaz:
https://doaj.org/article/c5c6d2eaf476483e8131d6ef30d97d79
Publikováno v:
Chemical Reviews.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4688d79daf0c8548224bbbff054c051
https://doi.org/10.1021/acs.chemrev.2c00851
https://doi.org/10.1021/acs.chemrev.2c00851
Publikováno v:
Methods
Biomolecular condensates often consist of intrinsically disordered protein and RNA molecules, which together promote the formation of membraneless organelles in cells. The nucleation, condensation, and maturation of condensates is a critical yet poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3102ca179d71899d9bf2d89ad6cf491
https://doi.org/10.1016/j.ymeth.2021.02.012
https://doi.org/10.1016/j.ymeth.2021.02.012
Karyopherin-β2 (Kapβ2) is a nuclear-import receptor that recognizes proline-tyrosine nuclear localization signals (PY-NLSs) of diverse cytoplasmic cargo for transport to the nucleus. Kapβ2 cargo include several disease-linked RNA-binding proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ec3e46de2438877e6b1fbb1fc9af16a
https://doi.org/10.1101/2022.09.14.508025
https://doi.org/10.1101/2022.09.14.508025
Publikováno v:
Cytoskeleton. 78:129-141
The glycolytic enzyme fructose 1,6-(bis)phosphate aldolase (aldolase) is not only required for efficient utilization of glucose and fructose, but also for cytoskeletal functions like cytokinesis and cell motility. These differing roles are mediated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0221a7756571b735a4bf3362dc6d933e
https://doi.org/10.1002/cm.21646
https://doi.org/10.1002/cm.21646
Autor:
Charlotte M. Fare, Vladislav A. Korobeynikov, Kevin Rhine, Joey Yoniles, Sua Myong, Neil A. Shneider, James Shorter
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fe11ef617d6f4220be47cd484e51694
https://doi.org/10.1096/fasebj.2022.36.s1.r2282
https://doi.org/10.1096/fasebj.2022.36.s1.r2282
Autor:
Sua Myong, Kevin Rhine, Joey Yoniles, Morgan Dasovich, Mohsen Badiee, Sophie Skanchy, Laura Ganser, Yingda Ge, Charlotte Fare, James Shorter, Anthony K. Leung
Publikováno v:
Biophysical Journal. 122:157a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d93af926ef65d13082034bad6f59e0ee
https://doi.org/10.1016/j.bpj.2022.11.968
https://doi.org/10.1016/j.bpj.2022.11.968
Autor:
Kevin Rhine, James Shorter, Sophie Skanchy, Sua Myong, Charlotte M. Fare, Joseph Yoniles, Laura R. Ganser, Anthony K.L. Leung, Morgan Dasovich, Mohsen Badiee
Publikováno v:
SSRN Electronic Journal.
Poly(ADP-ribose) (PAR) is an RNA-like polymer that regulates an increasing number of biological processes. Dysregulation of PAR is implicated in neurodegenerative diseases characterized by abnormal protein aggregation, including Amyotrophic Lateral S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c515e98640996dcd58f729e2457b1bf4
https://doi.org/10.2139/ssrn.3890382
https://doi.org/10.2139/ssrn.3890382