Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kevin R. Steffy"'
Autor:
Stephen E. Webber, Amit M. Shah, Kevin R. Steffy, James R. Appleman, Alan X. Xiang, Robert M. Aust, Thomas Doundoulakis, Richard E. Showalter, Klaus B. Simonsen, William T. Biller, Virginia N. Banh, Wes Sisson, Ricardo Lira, Konstantinos A. Agrios
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6797-6800
Based upon observations from our initial findings, additional myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against Escherichia coli and Staphyloco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cb065632e8fb157a6e76b6add4692a
https://doi.org/10.1016/j.bmcl.2007.10.017
https://doi.org/10.1016/j.bmcl.2007.10.017
Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection
Autor:
Lisa A Bauman, Eckart Schott, Bradley M. Kerr, Yves Horsmans, Tobias Mueller, Kevin R. Steffy, Averett Devron R, Simon P. Fletcher, Jean-Pierre Desager, Thomas Berg
Publikováno v:
Hepatology. 42:724-731
Immune-based therapy is the mainstay treatment for chronic hepatitis C virus (HCV) infection but causes multiple side effects and achieves durable viral clearance in only approximately 50% of patients. Most new investigational anti-HCV compounds are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acf5bcd8b0f2d29ece7a99c66b996b9
https://doi.org/10.1002/hep.20839
https://doi.org/10.1002/hep.20839
Publikováno v:
Journal of General Virology. 76:1069-1072
The complete nucleotide sequence of the gene encoding the protease and ICP35 capsid protein of herpes simplex virus (HSV) type 2 strain G has been determined. The gene consisits of a 1908 bp open reading frame capable of encoding 636 amino acids. Com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874c57d1df611c8328c053a9882d11d5
https://doi.org/10.1099/0022-1317-76-4-1069
https://doi.org/10.1099/0022-1317-76-4-1069
Autor:
Stephen E. Webber, Virginia N. Banh, Erik J. Rueden, Wei Li, Gregory J. Haley, Darian M. Bartkowski, Clark David Louis, Tingmin Wang, John S Ng, Mark R Herbert, Bradley M. Kerr, Leonid I Kirkovsky, Joseph R. Lennox, Alan X. Xiang, Averett Devron R, Simon P. Fletcher, Kevin R. Steffy, Lisa A Bauman
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 26(6-7)
ANA975, a 5-amino-3-beta -D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one derivative, was synthesized in the search of an oral prodrug of isatoribine, a small molecule toll-like receptor 7 (TLR-7) agonist. Several strategies were studied to enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c61fb0f92ee40e3908ff45614ab565
https://pubmed.ncbi.nlm.nih.gov/18066870
https://pubmed.ncbi.nlm.nih.gov/18066870
Autor:
Akhteruzzaman Molla, Robert J Carrick, Minghua Sun, William E Kohlbrenner, Kent D. Stewart, Krueger Allan C, Chen Zhao, Warren M. Kati, K. C. Marsh, Dale J. Kempf, Kevin R. Steffy, Clarence J. Maring, Anita J Kempf-Grote, Yibo Xu, W. Graeme Laver, Vincent S. Stoll, Darold L. Madigan, Debra Montgomery, Yu-Gui Gu, Hing L. Sham
Publikováno v:
Journal of medicinal chemistry. 48(12)
The structure-activity relationship (SAR) of a novel hydrophobic binding interaction within a subsite of the influenza neuraminidase (NA) active site was characterized and optimized for a series of trisubstituted pyrrolidine inhibitors modified at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7cb1ee1d2f796304bfb66e1f69c37c
https://pubmed.ncbi.nlm.nih.gov/15943472
https://pubmed.ncbi.nlm.nih.gov/15943472
Autor:
Teresa I. Ng, William E. Kohlbrenner, Akhteruzzaman Molla, Kent D. Stewart, Yan Shi, Debra Montgomery, Kevin R. Steffy, Robert J Carrick, Vincent S. Stoll, Warren M. Kati, Clarence J. Maring, Dale J. Kempf, Nanette Gusick
Publikováno v:
Journal of virology. 76(11)
With the recent introduction of neuraminidase (NA) inhibitors into clinical practice for the treatment of influenza virus infections, considerable attention has been focused on the potential for resistance development and cross-resistance between dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c11c6a828d575f1dbc65fecddbc1ef
https://pubmed.ncbi.nlm.nih.gov/11991966
https://pubmed.ncbi.nlm.nih.gov/11991966
Autor:
Kevin R. Steffy, Dale J. Kempf, Akhteruzzaman Molla, Debra Montgomery, Robert J Carrick, Warren M. Kati, Keith F. McDaniel, Frederick G. Hayden, William E. Kohlbrenner, Clarence J. Maring, Larisa V. Gubareva
A-315675 is a novel, pyrrolidine-based compound that was evaluated in this study for its ability to inhibit A and B strain influenza virus neuraminidases in enzyme assays and influenza virus replication in cell culture. A-315675 effectively inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f526c4b36090030e3aaf5593a57375b
https://europepmc.org/articles/PMC127111/
https://europepmc.org/articles/PMC127111/
Publikováno v:
Gene. 89(2)
A herpes simplex virus type 1 (HSV-1) insertion vector, pGal8, was designed for analysis of herpesvirus promoters during virus infection. This vector contains a multiple cloning site (MCS) positioned at the 5' end of the lacZ gene for the insertion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ba4fded788f35431b03d26a06434bb
https://pubmed.ncbi.nlm.nih.gov/2165021
https://pubmed.ncbi.nlm.nih.gov/2165021