Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kevin R. Shreder"'
Autor:
Allister Fraser, Kevin R. Shreder, Junichi Ishiyama, John W. Kozarich, Yi Hu, Yasushi Kohno, Heidi E. Brown, Lingling Du, Eric Okerberg, Christopher M. Amantea, Julia Cajica, Emme C.K. Lin, Lan M. Pham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1553-1556
AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid, was identified as a Zn2+-dependent, 27 nM inhibitor of human plasma Lp-PLA2. Structure–activity relationship studies focused on the AX10479 2-phenylamide gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c315b99f9891368e7cffabc5de59502a
https://doi.org/10.1016/j.bmcl.2012.11.048
https://doi.org/10.1016/j.bmcl.2012.11.048
Autor:
Eric Okerberg, Julia Cajica, Kevin R. Shreder, Yasushi Kohno, Lan M. Pham, Heidi E. Brown, Junichi Ishiyama, Yi Hu, John W. Kozarich, Allister Fraser, Lingling Du, Emme C.K. Lin, Christopher M. Amantea
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:868-871
AX10185, the phenyl amide of xanthurenic acid, was found to be a sub-100 nM inhibitor of Lp-PLA2. However, in the presence of EDTA the inhibitory activity of AX10185 was extinguished while the enzymatic activity of Lp-PLA2 did not change. Subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de185b106366a37c0bc14bd62e17a668
https://doi.org/10.1016/j.bmcl.2011.12.045
https://doi.org/10.1016/j.bmcl.2011.12.045
Autor:
Kevin R. Shreder, Tyzoon K. Nomanbhoy, Ayako Nakamura, Anna Katrin Szardenings, Shigeki Seto, Jonathan S. Rosenblum, Brandon Leen, Oana Cociorva, Kai Nakamura, Bei Li, Marek Liyanage, John W. Kozarich, Qiang Li, Yasushi Kohno, Kazuhiro Yumoto, Kyoko Okada, Masahiro Nomura, Melissa C. Zhang, Arwin Aban
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5948-5951
The synthesis, GSK-3β inhibitory activity, and anti-microbial activity of bicyclic and tricyclic derivatives of the 5,7-diamino-6-fluoro-4-quinolone-3-carboxylic acid scaffold were studied. Kinase selectivity profiling indicated that members of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d9755d781aad544131d0a6c744f45f
https://doi.org/10.1016/j.bmcl.2011.07.073
https://doi.org/10.1016/j.bmcl.2011.07.073
Autor:
Wenzhi Gai, Sergio Corral, Jonathan S. Rosenblum, Kevin R. Shreder, Douglas K. Ferris, Yongsheng Liu
Publikováno v:
Chemistry & Biology. 12:99-107
SummaryPolo-like kinases (PLKs) play critical roles throughout mitosis. Here, we report that wortmannin, which was previously thought to be a highly selective inhibitor of phosphoinositide (PI) 3-kinases, is a potent inhibitor of mammalian PLK1. Obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d49fe221d29d31ac3321095f75129c8
https://doi.org/10.1016/j.chembiol.2004.11.009
https://doi.org/10.1016/j.chembiol.2004.11.009
Publikováno v:
Organic Letters. 6:3715-3718
[structure: see text] The synthesis of a photoaffinity probe for EGFR is described. O-Alkylation of 4-(meta-azidoanilino)-6-methoxy-7-hydroxy-quinazoline with a protected tetraethyleneglycol linker followed by the attachment of tetramethylrhodamine y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3977075c421407a793e34a5fc5052da
https://doi.org/10.1021/ol048656a
https://doi.org/10.1021/ol048656a
Publikováno v:
Bioconjugate Chemistry. 11:557-563
The electrospray ionization-mass spectrometry (ESI-MS) analysis of three sets of monoclonal antibody-acridinium-9-carboxamide conjugates is described. The conjugates (nine total) were enzymatically digested using papain and the resulting fragments [F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3843beb5641520cf56e82b94cf99be6f
https://doi.org/10.1021/bc990181y
https://doi.org/10.1021/bc990181y
Publikováno v:
Bioconjugate Chemistry. 10:1032-1037
Surface plasmon resonance (SPR) analysis was used to assess the immunoreactivity of anti-biotin (4) and anti-fluorescein (5) monoclonal antibody after conjugation with the N-hydroxysuccinimide ester of acridinium-9-carboxamide 1. Only minor changes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7d7692d44dbae09dc34947bd7b7559
https://doi.org/10.1021/bc990057e
https://doi.org/10.1021/bc990057e
Autor:
Kai Nakamura, Qiang Li, Tyzoon K. Nomanbhoy, Ann Yu-Jung Shih, Helge Weissig, Oana Cociorva, Lan Pham, John W. Kozarich, Yi Hu, Melissa C. Zhang, Marek Liyanage, Julia Cajica, Kevin R. Shreder, Arwin Aban, Bei Li
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(18)
As the result of a rhJNK1 HTS, the imidazo[1,2-a]quinoxaline 1 was identified as a 1.6 μM rhJNK1 inhibitor. Optimization of this compound lead to AX13587 (rhJNK1 IC50 = 160 nM) which was co-crystallized with JNK1 to identify key molecular interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b642fbafafceb853661bc276b0d062
https://pubmed.ncbi.nlm.nih.gov/23916259
https://pubmed.ncbi.nlm.nih.gov/23916259
Autor:
Yi, Hu, Emme C K, Lin, Lan M, Pham, Julia, Cajica, Christopher M, Amantea, Eric, Okerberg, Heidi E, Brown, Allister, Fraser, Lingling, Du, Yasushi, Kohno, Junichi, Ishiyama, John W, Kozarich, Kevin R, Shreder
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(5)
AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid, was identified as a Zn(2+)-dependent, 27nM inhibitor of human plasma Lp-PLA(2). Structure-activity relationship studies focused on the AX10479 2-phenylamide gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b34b44aa3a62c9cf8f531166843fd435
https://pubmed.ncbi.nlm.nih.gov/23333209
https://pubmed.ncbi.nlm.nih.gov/23333209
Autor:
Kevin R. Shreder, Jonathan S. Rosenblum, Allister Fraser, Ethel McGee, Christopher M. Amantea, Yi Hu, Emme C.K. Lin, Lan M. Pham, John W. Kozarich, Heidi E. Brown, De Michael Chung, Jiangyue Wu, Julia Cajica, Eric Okerberg
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(17)
KIAA1363 is a serine hydrolase whose activity has been shown to be positively associated with tumor cell invasiveness. Thus, inhibitors of KIAA1363 represent a novel targeted therapy approach towards cancer. AX11890 ((1-bromo-2-naphthyl) N,N-dimethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46c4de3cd2c577bc674e8522279d5de
https://pubmed.ncbi.nlm.nih.gov/22877630
https://pubmed.ncbi.nlm.nih.gov/22877630