Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Kevin R. MacKenzie"'
Autor:
Rajesh Sharma, Kyoung-Jae Choi, My Diem Quan, Sonum Sharma, Banumathi Sankaran, Hyekyung Park, Anel LaGrone, Jean J. Kim, Kevin R. MacKenzie, Allan Chris M. Ferreon, Choel Kim, Josephine C. Ferreon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
KLF4, OCT4, SOX2 and MYC cooperate to reorganize chromatin during somatic cell reprogramming. Here the authors show that KLF4 forms a liquid-like biomolecular condensate that recruits OCT4 and SOX2, and that condensation of the isolated KLF4 DNA bind
Externí odkaz:
https://doaj.org/article/64a6612989c448e0aa3b7aff1d6e39fe
Autor:
Lyra Chang, James Campbell, Idris O. Raji, Shiva K. R. Guduru, Prasanna Kandel, Michelle Nguyen, Steven Liu, Kevin Tran, Navneet K. Venugopal, Bethany C. Taylor, Matthew V. Holt, Nicolas L. Young, Errol L. G. Samuel, Prashi Jain, Conrad Santini, Banumathi Sankaran, Kevin R. MacKenzie, Damian W. Young
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Despite the established roles of the epigenetic factor UHRF1 in oncogenesis, no UHRF1-targeting therapeutics have been reported to date. In this study, we use fragment-based ligand discovery to identify novel scaffolds for targeting the isol
Externí odkaz:
https://doaj.org/article/5972f93c7d5b4a20bcf0f3bca4897227
Autor:
Srinivas Chamakuri, Sunny Ann Tang, Kevin A. Tran, Shiva Krishna Reddy Guduru, Peter K. Bolin, Kevin R. MacKenzie, Damian W. Young
Publikováno v:
Molecules, Vol 27, Iss 11, p 3419 (2022)
We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five
Externí odkaz:
https://doaj.org/article/e03a14a45cc14395a67b86b6084b9499
Autor:
Xiqian Jiang, Jianwei Chen, Aleksandar Bajić, Chengwei Zhang, Xianzhou Song, Shaina L. Carroll, Zhao-Lin Cai, Meiling Tang, Mingshan Xue, Ninghui Cheng, Christian P. Schaaf, Feng Li, Kevin R. MacKenzie, Allan Chris M. Ferreon, Fan Xia, Meng C. Wang, Mirjana Maletić-Savatić, Jin Wang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Fluorescent sensors for small biomolecules are needed to shed insight into real-time cellular processes. Here the authors develop RealThiol, a sensor that can quantitatively monitor glutathione dynamics in living cells, and measure increased antioxid
Externí odkaz:
https://doaj.org/article/44beb87514aa4446b912f029a49d9432
Autor:
Josephine C. Ferreon, Antrix Jain, Kyoung-Jae Choi, Phoebe S. Tsoi, Kevin R. MacKenzie, Sung Yun Jung, Allan Chris Ferreon
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 5, p 1360 (2018)
Neuropathological aggregates of the intrinsically disordered microtubule-associated protein Tau are hallmarks of Alzheimer’s disease, with decades of research devoted to studying the protein’s aggregation properties both in vitro and in vivo. Rec
Externí odkaz:
https://doaj.org/article/831668b6f17a4ab484c46ee2bac4a57e
Autor:
Xiqian Jiang, Jianwei Chen, Aleksandar Bajić, Chengwei Zhang, Xianzhou Song, Shaina L. Carroll, Zhao-Lin Cai, Meiling Tang, Mingshan Xue, Ninghui Cheng, Christian P. Schaaf, Feng Li, Kevin R. MacKenzie, Allan Chris M. Ferreon, Fan Xia, Meng C. Wang, Mirjana Maletić-Savatić, Jin Wang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number: 16087 (2017); Published 13 July 2017; Updated 3 October 2017. Previous work by Cho and Choi describing the development of a cyanoacrylamide-based fluorescence sensor for reversible detection of thiols in homog
Externí odkaz:
https://doaj.org/article/05dc9b0ff07143d8a1d16c74407b3307
Autor:
Xuan Qin, Stephen Palmer, Mercedes Barzi, Pranavanand Nyshadham, Sung Yun Jung, Karl-Dimiter Bissig, Joie Guner, Martin M. Matzuk, John M. Hakenjos, Si Chen, Kevin R. MacKenzie, Hemantkumar Chavan, Partha Krishnamurthy, Jin Wang, Lei Guo, Feng Li
Publikováno v:
Drug Metabolism and Disposition. 50:128-139
Duloxetine (DLX) is a dual serotonin and norepinephrine reuptake inhibitor, widely used for the treatment of major depressive disorder. Although DLX has shown good efficacy and safety, serious adverse effects (e.g., liver injury) have been reported.
Autor:
Qiuji Ye, Hassane Belabed, Yong Wang, Zhifeng Yu, Murugesan Palaniappan, Jian‐Yuan Li, Stacey A. Kalovidouris, Kevin R. MacKenzie, Mingxing Teng, Damian W. Young, Yoshitaka Fujihara, Martin M. Matzuk
Publikováno v:
Andrology.
A safe, effective, and reversible nonhormonal male contraceptive drug is greatly needed for male contraception as well as for circumventing the side effects of female hormonal contraceptives. Phosducin-like 2 (PDCL2) is a testis-specific phosphoprote
Autor:
Xuan Qin, Cen Xie, John M. Hakenjos, Kevin R. MacKenzie, Shelton R. Boyd, Mercedes Barzi, Karl-Dimiter Bissig, Damian W. Young, Feng Li
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 181
Duloxetine (DLX) is widely used to treat major depressive disorder. Little is known about the mechanistic basis for DLX-related adverse effects (e.g., liver injury). Human CYP1A2 and CYP2D6 mainly contributes to DLX metabolism, which was proposed to
Autor:
Rajesh Sharma, Jeong Joo Kim, Liying Qin, Philipp Henning, Madoka Akimoto, Bryan VanSchouwen, Gundeep Kaur, Banumathi Sankaran, Kevin R MacKenzie, Giuseppe Melacini, Darren E Casteel, Friedrich W Herberg, Choel Kim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::557df9914d03cda2c9f5b18647e1cc29
https://doi.org/10.7554/elife.79530.sa2
https://doi.org/10.7554/elife.79530.sa2