Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kevin R. Bersell"'
Autor:
Kevin R. Bersell, Tao Yang, Jonathan D. Mosley, Andrew M. Glazer, Andrew T. Hale, Dmytro O. Kryshtal, Kyungsoo Kim, Jeffrey D. Steimle, Jonathan D. Brown, Joe-Elie Salem, Courtney C. Campbell, Charles C. Hong, Quinn S. Wells, Amanda N. Johnson, Laura Short, Marcia A. Blair, Elijah R. Behr, Evmorfia Petropoulou, Yalda Jamshidi, Mark D. Benson, Michelle J. Keyes, Debby Ngo, Ramachandran S. Vasan, Qiong Yang, Robert E. Gerszten, Christian Shaffer, Shan Parikh, Quanhu Sheng, Prince J. Kannankeril, Ivan P. Moskowitz, John D. York, Thomas J. Wang, Bjorn C. Knollmann, Dan M. Roden
Publikováno v:
Circulation. 147:824-840
Background: Brugada syndrome (BrS) is an inherited arrhythmia syndrome caused by loss-of-function variants in the cardiac sodium channel gene SCN5A (sodium voltage-gated channel alpha subunit 5) in ≈20% of subjects. We identified a family with 4 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdd1ac34ae82ff8a9ad6eaf1e5d9d09
https://doi.org/10.1161/circulationaha.122.062193
https://doi.org/10.1161/circulationaha.122.062193
Publikováno v:
Methods in Molecular Biology ISBN: 9781071606674
Methods Mol Biol
Methods Mol Biol
Procurement and characterization of intact human cells are essential for studies in regenerative medicine and translational medical research. The selection of the currently available approaches to isolate intact cells depends on the age of the hearts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b631baa8edcc1d7b6310cc0b48c9c79b
https://doi.org/10.1007/978-1-0716-0668-1_15
https://doi.org/10.1007/978-1-0716-0668-1_15
Autor:
Lili Wang, Kyungsoo Kim, Huan He, Dmytro O. Kryshtal, Jose R. Pinto, Bjorn C. Knollmann, Adrian G. Cadar, Kevin R. Bersell, Shan Parikh
Publikováno v:
Journal of Molecular and Cellular Cardiology. 114:320-327
Background Mutations in cardiac troponin T (TnT) are linked to increased risk of ventricular arrhythmia and sudden death despite causing little to no cardiac hypertrophy. Studies in mice suggest that the hypertrophic cardiomyopathy (HCM)-associated T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9894c4316d30c8b00ddc81d5f99b760d
https://doi.org/10.1016/j.yjmcc.2017.12.002
https://doi.org/10.1016/j.yjmcc.2017.12.002
Autor:
Bonnie Ky, Joshua C. Denny, Elizabeth P Held, Michael J. Fisch, Peter Weeke, Christian M. Shaffer, Dan M. Roden, Chase S. Lindsay, Aron Y. Joon, Yan Ru Su, Daniel J. Lenihan, Joshua P. Fessel, Ziding Feng, Jason H. Karnes, Olivia J. Veatch, Kevin R. Bersell, Lore W. Lagrone, Marcia Blair, Erica Bowton, Rebecca T. Levinson, Jonathan D. Mosley, Sara L. Van Driest, Quinn S. Wells, Andrew M. Glazer
Publikováno v:
Pharmacogenetics and Genomics. 27:247-254
Background Anthracyclines are important chemotherapeutic agents, but their use is limited by cardiotoxicity. Candidate gene and genome-wide studies have identified putative risk loci for overt cardiotoxicity and heart failure, but there has been no c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2383c199e05dec9b081ddc68fc8f05dc
https://doi.org/10.1097/fpc.0000000000000284
https://doi.org/10.1097/fpc.0000000000000284
Autor:
Chee Chew Lim, Michael Gotthardt, Lili Wang, Joseph A. Balsamo, Charles C. Hong, Dan M. Roden, Bjorn C. Knollmann, Tromondae K. Feaster, Young-Jae Nam, Kevin R. Bersell, Young Wook Chun, Adrian G. Cadar, TingTing Hong, Zhentao Zhang
Publikováno v:
Am J Physiol Cell Physiol
Fluorescence recovery after photobleaching (FRAP) has been useful in delineating cardiac myofilament biology, and innovations in fluorophore chemistry have expanded the array of microscopic assays used. However, one assumption in FRAP is the irrevers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce82c28c2da4feda2092c9737a0caae
https://pubmed.ncbi.nlm.nih.gov/31747312
https://pubmed.ncbi.nlm.nih.gov/31747312
Autor:
Cameron T Nutt, Kevin R. Bersell
Publikováno v:
JAMA Internal Medicine. 181:113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb4edae1f0ec37a2251849d9e718e09
https://doi.org/10.1001/jamainternmed.2020.5660
https://doi.org/10.1001/jamainternmed.2020.5660
Autor:
Joe-Elie Salem, Kevin R. Bersell, Dan M. Roden, Joachim Alexandre, Javid Moslehi, Christian Funck-Brentano
Publikováno v:
Pharmacologytherapeutics. 189
Significant advances in cancer treatment have resulted in decreased cancer related mortality for many malignancies with some cancer types now considered chronic diseases. Despite these improvements, there is increasing recognition that many cancer pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91b25306b6b29961ca1e917db6cbcde
https://pubmed.ncbi.nlm.nih.gov/29698683
https://pubmed.ncbi.nlm.nih.gov/29698683
Autor:
Adrian G. Cadar, Bjorn C. Knollmann, Lili Wang, Kyungsoo Kim, Shan Parikh, Dmytro O. Kryshtal, Jose R. Pinto, Huan He, Kevin R. Bersell
Publikováno v:
Journal of the American College of Cardiology. 70(20)
Familial hypertrophic cardiomyopathy is caused by mutations in genes encoding sarcomere proteins. Among hypertrophic cardiomyopathy–linked disease genes, cardiac troponin T (TnT) mutations are associated with a high incidence of arrhythmic cardiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd6f48d37aa7e24d3164fb095919c03
https://pubmed.ncbi.nlm.nih.gov/29145956
https://pubmed.ncbi.nlm.nih.gov/29145956
Autor:
Robert L. Bjork, Jennifer A. Kearney, Alfred L. George, Siddharth Gupta, Julie S. Cohen, Jennifer Friedman, Carlos G. Vanoye, Sakkubai Naidu, Benjamin S. Jorge, Kevin R. Bersell, Cinnamon S. Bloss, Ali Torkamani
Publikováno v:
Annals of Neurology. 76:529-540
Objective Numerous studies have demonstrated increased load of de novo copy number variants or single nucleotide variants in individuals with neurodevelopmental disorders, including epileptic encephalopathies, intellectual disability, and autism. Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6499ebe5739672ad0432edf997e81386
https://doi.org/10.1002/ana.24263
https://doi.org/10.1002/ana.24263
Autor:
Brian Wadugu, Sangita Choudhury, Mariya Mollova, Balakrishnan Ganapathy, Shima Arab, Stuart Walsh, Kevin R. Bersell, Bernhard Kühn, Brian D. Polizzotti
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 6, Pp 1459-1469 (2013)
Disease Models & Mechanisms
Disease Models & Mechanisms
Summary Numerous mouse models have utilized Cre-loxP technology to modify gene expression. Adverse effects of Cre recombinase activity have been reported, including in the heart. However, the mechanisms associated with cardiac Cre toxicity are largel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135c119c1cf38b2f2641939800cb5789
http://dmm.biologists.org/content/6/6/1459
http://dmm.biologists.org/content/6/6/1459