Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Kevin R MacKenzie"'
Autor:
Rajesh Sharma, Jeong Joo Kim, Liying Qin, Philipp Henning, Madoka Akimoto, Bryan VanSchouwen, Gundeep Kaur, Banumathi Sankaran, Kevin R MacKenzie, Giuseppe Melacini, Darren E Casteel, Friedrich W Herberg, Choel Kim
Publikováno v:
eLife, Vol 11 (2022)
Cyclic GMP-dependent protein kinases (PKGs) are key mediators of the nitric oxide/cyclic guanosine monophosphate (cGMP) signaling pathway that regulates biological functions as diverse as smooth muscle contraction, cardiac function, and axon guidance
Externí odkaz:
https://doaj.org/article/e51c69fdbce043f9a7cfb5d14e739a4b
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1125 (2024)
Cytochrome P450 enzymes (P450s) play a critical role in drug metabolism, with the CYP3A subfamily being responsible for the biotransformation of over 50% of marked drugs. While CYP3A enzymes are known for their extensive catalytic versatility, one in
Externí odkaz:
https://doaj.org/article/75d7e92570dc4790b993f72eebdc0df1
Autor:
Rajesh Sharma, Kyoung-Jae Choi, My Diem Quan, Sonum Sharma, Banumathi Sankaran, Hyekyung Park, Anel LaGrone, Jean J. Kim, Kevin R. MacKenzie, Allan Chris M. Ferreon, Choel Kim, Josephine C. Ferreon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
KLF4, OCT4, SOX2 and MYC cooperate to reorganize chromatin during somatic cell reprogramming. Here the authors show that KLF4 forms a liquid-like biomolecular condensate that recruits OCT4 and SOX2, and that condensation of the isolated KLF4 DNA bind
Externí odkaz:
https://doaj.org/article/64a6612989c448e0aa3b7aff1d6e39fe
Autor:
Lyra Chang, James Campbell, Idris O. Raji, Shiva K. R. Guduru, Prasanna Kandel, Michelle Nguyen, Steven Liu, Kevin Tran, Navneet K. Venugopal, Bethany C. Taylor, Matthew V. Holt, Nicolas L. Young, Errol L. G. Samuel, Prashi Jain, Conrad Santini, Banumathi Sankaran, Kevin R. MacKenzie, Damian W. Young
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Despite the established roles of the epigenetic factor UHRF1 in oncogenesis, no UHRF1-targeting therapeutics have been reported to date. In this study, we use fragment-based ligand discovery to identify novel scaffolds for targeting the isol
Externí odkaz:
https://doaj.org/article/5972f93c7d5b4a20bcf0f3bca4897227
Autor:
Srinivas Chamakuri, Sunny Ann Tang, Kevin A. Tran, Shiva Krishna Reddy Guduru, Peter K. Bolin, Kevin R. MacKenzie, Damian W. Young
Publikováno v:
Molecules, Vol 27, Iss 11, p 3419 (2022)
We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five
Externí odkaz:
https://doaj.org/article/e03a14a45cc14395a67b86b6084b9499
Autor:
Xiqian Jiang, Jianwei Chen, Aleksandar Bajić, Chengwei Zhang, Xianzhou Song, Shaina L. Carroll, Zhao-Lin Cai, Meiling Tang, Mingshan Xue, Ninghui Cheng, Christian P. Schaaf, Feng Li, Kevin R. MacKenzie, Allan Chris M. Ferreon, Fan Xia, Meng C. Wang, Mirjana Maletić-Savatić, Jin Wang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Fluorescent sensors for small biomolecules are needed to shed insight into real-time cellular processes. Here the authors develop RealThiol, a sensor that can quantitatively monitor glutathione dynamics in living cells, and measure increased antioxid
Externí odkaz:
https://doaj.org/article/44beb87514aa4446b912f029a49d9432
Autor:
Xuan Qin, Stephen Palmer, Mercedes Barzi, Pranavanand Nyshadham, Sung Yun Jung, Karl-Dimiter Bissig, Joie Guner, Martin M. Matzuk, John M. Hakenjos, Si Chen, Kevin R. MacKenzie, Hemantkumar Chavan, Partha Krishnamurthy, Jin Wang, Lei Guo, Feng Li
Publikováno v:
Drug Metabolism and Disposition. 50:128-139
Duloxetine (DLX) is a dual serotonin and norepinephrine reuptake inhibitor, widely used for the treatment of major depressive disorder. Although DLX has shown good efficacy and safety, serious adverse effects (e.g., liver injury) have been reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9ccca6d77ac68a2616551432aa4aa9
https://doi.org/10.1124/dmd.121.000633
https://doi.org/10.1124/dmd.121.000633
Autor:
Qiuji Ye, Hassane Belabed, Yong Wang, Zhifeng Yu, Murugesan Palaniappan, Jian‐Yuan Li, Stacey A. Kalovidouris, Kevin R. MacKenzie, Mingxing Teng, Damian W. Young, Yoshitaka Fujihara, Martin M. Matzuk
Publikováno v:
Andrology.
A safe, effective, and reversible nonhormonal male contraceptive drug is greatly needed for male contraception as well as for circumventing the side effects of female hormonal contraceptives. Phosducin-like 2 (PDCL2) is a testis-specific phosphoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b8a2db42b1cdebed5aea0590166c3e
https://doi.org/10.1111/andr.13309
https://doi.org/10.1111/andr.13309
Autor:
Xuan Qin, Cen Xie, John M. Hakenjos, Kevin R. MacKenzie, Shelton R. Boyd, Mercedes Barzi, Karl-Dimiter Bissig, Damian W. Young, Feng Li
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 181
Duloxetine (DLX) is widely used to treat major depressive disorder. Little is known about the mechanistic basis for DLX-related adverse effects (e.g., liver injury). Human CYP1A2 and CYP2D6 mainly contributes to DLX metabolism, which was proposed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5105752fb5a3dd013dfd77cab6efd808
https://pubmed.ncbi.nlm.nih.gov/36513193
https://pubmed.ncbi.nlm.nih.gov/36513193
Autor:
Rajesh Sharma, Jeong Joo Kim, Liying Qin, Philipp Henning, Madoka Akimoto, Bryan VanSchouwen, Gundeep Kaur, Banumathi Sankaran, Kevin R MacKenzie, Giuseppe Melacini, Darren E Casteel, Friedrich W Herberg, Choel Kim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::557df9914d03cda2c9f5b18647e1cc29
https://doi.org/10.7554/elife.79530.sa2
https://doi.org/10.7554/elife.79530.sa2
