Regulation of Polycystin-1 Function by Calmodulin Binding.

Autor: Nicholas Doerr, Yidi Wang, Kevin R Kipp, Guangyi Liu, Jesse J Benza, Vladimir Pletnev, Tengis S Pavlov, Alexander Staruschenko, Ashraf M Mohieldin, Maki Takahashi, Surya M Nauli, Thomas Weimbs

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0161525 (2016)

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disease that leads to progressive renal cyst growth and loss of renal function, and is caused by mutations in the genes encoding polycystin-1 (PC1) and polycystin-2 (PC2), respe

Externí odkaz: https://doaj.org/article/2dd1bd64898141e3a8683112f025fee9

Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression

Autor: Masaw Akbari, Jonathan D. West, Nicholas Doerr, Kevin R. Kipp, Neda Marhamati, Sabrina Vuong, Yidi Wang, Markus M. Rinschen, Jeffrey J. Talbot, Oliver Wessely, Thomas Weimbs

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 30
Akbari, M, West, J D, Doerr, N, Kipp, K R, Marhamati, N, Vuong, S, Wang, Y, Rinschen, M M, Talbot, J J, Wessely, O & Weimbs, T 2022, ' Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 30, e2121267119 . https://doi.org/10.1073/pnas.2121267119

Autosomal dominant polycystic kidney disease (ADPKD) affects more than 500,000 individuals in the United States alone. In most cases, ADPKD is caused by a loss-of-function mutation in the PKD1 gene, which encodes polycystin-1 (PC1). Previous studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f72725d05c6f86d382499b53f3482e3
https://escholarship.org/uc/item/0rw4q0ck

Abstract LB143: BNZ-2, a dual specific IL15/IL21 inhibitor, rescues humanized NOG-IL15 transgenic mice from intestinal acute graft versus host disease without disrupting NK and CD8 T cell engraftment

Autor: Nick Doerr, Laith Q. Al-Mawsawi, Adrian J. Giovannone, Nazli Azimi, Kevin R. Kipp, Woo Jae Kim

Publikováno v: Cancer Research. 81:LB143-LB143

Advances in adoptive transfer immunotherapy have found beneficial effects for Interleukin-15 (IL-15) in the graft versus tumor (GvT) activity of NK and cytotoxic T cells. However, the benefits of this activity must be weighed against the increased ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f31729c0eb1167bb872dbdcea1c62f55
https://doi.org/10.1158/1538-7445.am2021-lb143

Regulation of Polycystin-1 Function by Calmodulin Binding

Autor: Guangyi Liu, Maki Takahashi, Jesse J. Benza, Ashraf M. Mohieldin, Surya M. Nauli, Kevin R. Kipp, Tengis S. Pavlov, Nicholas Doerr, Thomas Weimbs, Vladimir Z. Pletnev, Yidi Wang, Alexander Staruschenko

Publikováno v: PloS one, vol 11, iss 8
PLoS ONE
PLoS ONE, Vol 11, Iss 8, p e0161525 (2016)

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disease that leads to progressive renal cyst growth and loss of renal function, and is caused by mutations in the genes encoding polycystin-1 (PC1) and polycystin-2 (PC2), respe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3ba13798c5599980be5f04b0d3c0de
https://escholarship.org/uc/item/7pn0w1cg

Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells

Autor: Terra C. Gibbs, Zhihong Zhang, Yuhuan Xie, Kevin R. Kipp, Kathryn E. Meier, Maria V. Rubio

Publikováno v: The Prostate. 69:1493-1506

BACKGROUND Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are lipid mediators that bind to G-protein-coupled receptors. In this study, signaling responses to 18:1 LPA and S1P were examined in parallel in three human prostate cancer cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::254007b26fa054b89174cbc8ef63a800
https://doi.org/10.1002/pros.20994