Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Kevin R DeMarco"'
Autor:
Pei-Chi Yang, Shweta Purawat, Pek U Ieong, Mao-Tsuen Jeng, Kevin R DeMarco, Igor Vorobyov, Andrew D McCulloch, Ilkay Altintas, Rommie E Amaro, Colleen E Clancy
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 3, p e1006856 (2019)
Multi-scale computational modeling is a major branch of computational biology as evidenced by the US federal interagency Multi-Scale Modeling Consortium and major international projects. It invariably involves specific and detailed sequences of data
Externí odkaz:
https://doaj.org/article/a9798631d43e4238936e418a85225114
Autor:
Aiyana M. Emigh Cortez, Kevin R. DeMarco, Kazuharu Furutani, Slava Bekker, Jon T. Sack, Heike Wulff, Colleen E. Clancy, Igor Vorobyov, Vladimir Yarov-Yarovoy
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target. Genetic hERG mutations and blockage of the channe
Externí odkaz:
https://doaj.org/article/fd59e24e40c74bc3bfc831b84aa37187
Autor:
Yanxiao Han, John R. D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Yang K. Xiang, Igor Vorobyov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 10
G protein-coupled receptors (GPCRs) represent the largest group of membrane receptors for transmembrane signal transduction. Ligand-induced activation of GPCRs triggers G protein activation followed by various signaling cascades. Understanding the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc728f2ef17ee1e1039d0135f492c272
https://escholarship.org/uc/item/07j4d27h
https://escholarship.org/uc/item/07j4d27h
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Interactions of drug molecules with lipid membranes play crucial role in their accessibility of cellular targets and can be an important predictor of their therapeutic and safety profiles. Very little is known about spatial localization of various dr
Externí odkaz:
https://doaj.org/article/286d97eeea7c44c59fdb8d86279323f3
Autor:
Slava Bekker, Mao Tsuen Jeng, Heike Wulff, Colleen E. Clancy, Van A. Ngo, Pei Chi Yang, Kazuharu Furutani, James C. Fettinger, Vladimir Yarov-Yarovoy, Vikrant Singh, Igor Vorobyov, Sergei Y. Noskov, Jon T. Sack, Kevin R. DeMarco, John R. D. Dawson
Publikováno v:
Journal of Molecular and Cellular Cardiology. 158:163-177
Drug isomers may differ in their proarrhythmia risk. An interesting example is the drug sotalol, an antiarrhythmic drug comprising d- and l- enantiomers that both block the hERG cardiac potassium channel and confer differing degrees of proarrhythmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca30f9d545d92906b5d654c03d7da00
https://doi.org/10.1016/j.yjmcc.2021.05.015
https://doi.org/10.1016/j.yjmcc.2021.05.015
Autor:
Kevin R. DeMarco, Colleen E. Clancy, Jon T. Sack, Kazuharu Furutani, Aiyana M. Emigh, Igor Vorobyov, Jan Maly, Vladimir Yarov-Yarovoy
Publikováno v:
Frontiers in Pharmacology. 13
The voltage-gated potassium channel, KV11.1, encoded by the humanEther-à-go-go- Related Gene (hERG) is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential. Gating of hERG channel is characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a858ca5dbc793c44e95bd6202e7764
https://doi.org/10.3389/fphar.2022.966463
https://doi.org/10.3389/fphar.2022.966463
Autor:
Sergei Y. Noskov, Williams E. Miranda, Colleen E. Clancy, Jiqing Guo, Henry J. Duff, Igor Vorobyov, Kevin R. DeMarco
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 6
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
The human ether-á-go-go–related gene (hERG1) channel conducts small outward K(+) currents that are critical for cardiomyocyte membrane repolarization. The gain-of-function mutation N629D at the outer mouth of the selectivity filter (SF) disrupts i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f48c95afcebb85f80b44335862ef76
https://doi.org/10.1073/pnas.1909196117
https://doi.org/10.1073/pnas.1909196117
Autor:
Colleen E. Clancy, Slava Bekker, Igor Vorobyov, Kevin R. DeMarco, John R. D. Dawson, Parya Aghasafari, Pei Chi Yang, Mao Tsuen Jeng, Vladimir Yarov-Yarovoy, Sergei Y. Noskov
Publikováno v:
Circ Res
Circulation research, vol 126, iss 8
Circulation research, vol 126, iss 8
Rationale: Drug-induced proarrhythmia is so tightly associated with prolongation of the QT interval that QT prolongation is an accepted surrogate marker for arrhythmia. But QT interval is too sensitive a marker and not selective, resulting in many us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606ba9e912830203c6a7df20a1cf696d
https://europepmc.org/articles/PMC7155920/
https://europepmc.org/articles/PMC7155920/
Autor:
Yanxiao Han, Gonzalo Hernandez-Hernandez, Pei-Chi Yang, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Khoa Ngo, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Igor V. Vorobyov
Publikováno v:
Biophysical Journal. 121:286a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07f056af2521ecc0cfa931a53d9ede52
https://doi.org/10.1016/j.bpj.2021.11.1316
https://doi.org/10.1016/j.bpj.2021.11.1316
Autor:
Igor Vorobyov, Van A. Ngo, John R. D. Dawson, Pei Chi Yang, Colleen E. Clancy, Sergei Y. Noskov, Kazuharu Furutani, Kevin R. DeMarco, Slava Bekker, Vladimir Yarov-Yarovoy, Jon T. Sack
Publikováno v:
Biophysical Journal. 120:245a-246a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e68dd9a5c4a979b940563395944fceeb
https://doi.org/10.1016/j.bpj.2020.11.1605
https://doi.org/10.1016/j.bpj.2020.11.1605