Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kevin Qin"'
Autor:
Michael Yu, Kevin Qin, Jiaming Fan, Guozhi Zhao, Piao Zhao, Wei Zeng, Connie Chen, Annie Wang, Yonghui Wang, Jiamin Zhong, Yi Zhu, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin Ho, Michael J. Lee, Jason Strelzow, Russell R. Reid, Tong-Chuan He
Publikováno v:
Genes and Diseases, Vol 11, Iss 3, Pp 101026- (2024)
The evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and n
Externí odkaz:
https://doaj.org/article/8392f7d2b6e1410eb1a27610ae0740c2
Autor:
Kevin Qin, Michael Yu, Jiaming Fan, Hongwei Wang, Piao Zhao, Guozhi Zhao, Wei Zeng, Connie Chen, Yonghui Wang, Annie Wang, Zander Schwartz, Jeffrey Hong, Lily Song, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin H. Ho, Jason Strelzow, Russell R. Reid, Tong-Chuan He, Lewis L. Shi
Publikováno v:
Genes and Diseases, Vol 11, Iss 1, Pp 103-134 (2024)
Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transdu
Externí odkaz:
https://doaj.org/article/e9c5d2e8d60a4f7bab671fa685bf5817
Autor:
Linghuan Zhang, Wenping Luo, Jiang Liu, Maozhu Xu, Qi Peng, Wenjing Zou, Jingyi You, Yi Shu, Piao Zhao, William Wagstaff, Guozhi Zhao, Kevin Qin, Rex C. Haydon, Hue H. Luu, Russell R. Reid, Yang Bi, Tianyu Zhao, Tong-Chuan He, Zhou Fu
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Background A healthy alveolar epithelium is critical to the gas exchange function of the lungs. As the major cell type of alveolar epithelium, alveolar type 2 (AT2) cells play a critical role in maintaining pulmonary homeostasis by serving a
Externí odkaz:
https://doaj.org/article/eb81371f8db944edb708742645fa38e7
Autor:
Jing Li, Xiangdong Zhu, Matt T. Oberdier, Chunpei Lee, Shaoxia Lin, Sarah J. Fink, Cody N. Justice, Kevin Qin, Andrew W. Begeman, Frederick C. Damen, Hajwa Kim, Jiwang Chen, Kejia Cai, Henry R. Halperin, Terry L. Vanden Hoek
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
Out-of-hospital cardiac arrest is a leading cause of death in the US, with a mortality rate over 90%. Preclinical studies demonstrate that cooling during cardiopulmonary resuscitation (CPR) is highly beneficial, but can be challenging to implement cl
Externí odkaz:
https://doaj.org/article/21e1ed80f0e04c6797c226e941845f6f
Autor:
Feifei Pu, Fengxia Chen, Zhicai Zhang, Deyao Shi, Binlong Zhong, Xiao Lv, Andrew Blake Tucker, Jiaming Fan, Alexander J. Li, Kevin Qin, Daniel Hu, Connie Chen, Hao Wang, Fang He, Na Ni, Linjuan Huang, Qing Liu, William Wagstaff, Hue H. Luu, Rex C. Haydon, Le Shen, Tong-Chuan He, Jianxiang Liu, Zengwu Shao
Publikováno v:
Genes and Diseases, Vol 9, Iss 2, Pp 347-357 (2022)
The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy. Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells. Anti-tumor drugs were developed to induce apoptos
Externí odkaz:
https://doaj.org/article/7ada6379f31f407297d60e372884c349
Autor:
Mikhail Pakvasa, Pranav Haravu, Michael Boachie-Mensah, Alonzo Jones, Elam Coalson, Junyi Liao, Zongyue Zeng, Di Wu, Kevin Qin, Xiaoxing Wu, Huaxiu Luo, Jing Zhang, Meng Zhang, Fang He, Yukun Mao, Yongtao Zhang, Changchun Niu, Meng Wu, Xia Zhao, Hao Wang, Linjuan Huang, Deyao Shi, Qing Liu, Na Ni, Kai Fu, Michael J. Lee, Jennifer Moriatis Wolf, Aravind Athiviraham, Sherwin S. Ho, Tong-Chuan He, Kelly Hynes, Jason Strelzow, Mostafa El Dafrawy, Russell R. Reid
Publikováno v:
Genes and Diseases, Vol 8, Iss 1, Pp 8-24 (2021)
Notch is a cell–cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteog
Externí odkaz:
https://doaj.org/article/a4d47992f466402eb32b414c1d24bc69
Autor:
Fang He, Na Ni, Zongyue Zeng, Di Wu, Yixiao Feng, Alexander J. Li, Benjamin Luu, Alissa F. Li, Kevin Qin, Eric Wang, Xi Wang, Xiaoxing Wu, Huaxiu Luo, Jing Zhang, Meng Zhang, Yukun Mao, Mikhail Pakvasa, William Wagstaff, Yongtao Zhang, Changchun Niu, Hao Wang, Linjuan Huang, Deyao Shi, Qing Liu, Xia Zhao, Kai Fu, Russell R. Reid, Jennifer Moriatis Wolf, Michael J. Lee, Kelly Hynes, Jason Strelzow, Mostafa El Dafrawy, Hua Gan, Tong-Chuan He, Jiaming Fan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 885-899 (2020)
RNA interference (RNAi) is mediated by an ∼21-nt double-stranded small interfering RNA (siRNA) and shows great promise in delineating gene functions and in developing therapeutics for human diseases. However, effective gene silencing usually requir
Externí odkaz:
https://doaj.org/article/6d0374a049b84e5ab294d9468447091c
Autor:
Kevin Qin, Michael Yu, Jiaming Fan, Hongwei Wang, Piao Zhao, Guozhi Zhao, Wei Zeng, Connie Chen, Yonghui Wang, Annie Wang, Zander Schwartz, Jeffrey Hong, Lily Song, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin H. Ho, Jason Strelzow, Russell R. Reid, Tong-Chuan He, Lewis L. Shi
Publikováno v:
Genes & Diseases.
Publikováno v:
Journal of Bodywork and Movement Therapies. 29:74-85
Background Falls are common among People with Multiple Sclerosis (PwMS) and can result in significant consequences. Summary of the evidence of effectiveness of Physical Therapy (PT) to manage fall risks is needed. Objective To investigate the effecti
Autor:
Jing Li, Xiangdong Zhu, Matt Oberdier, Chunpei Lee, Misha Granado, Sarah Fink, Shaoxia Lin, Kevin Qin, CODY JUSTICE, Hajwa Kim, Frederick Damen, Kejia Cai, Pratik B Doshi, Henry Wang, Henry R Halperin, Terry L Vanden Hoek
Publikováno v:
Circulation. 144
Introduction: While effective for out-of-hospital cardiac arrest, therapeutic hypothermia can be difficult to timely implement clinically. No drugs exist for improving neurologically intact survival. We have developed a novel peptide (TAT-PHLPP) that