Výsledky vyhledávání - "Kevin P. Roarty"

Akademický článek

Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition

Autor: Na Zhao, Reid T. Powell, Xueying Yuan, Goeun Bae, Kevin P. Roarty, Fabio Stossi, Martina Strempfl, Michael J. Toneff, Hannah L. Johnson, Sendurai A. Mani, Philip Jones, Clifford C. Stephan, Jeffrey M. Rosen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

The epithelial-mesenchymal transition (EMT) has been implicated in stem cell properties and therapeutic resistance in cancer. Here, the authors show organoids derived from mesenchymal breast cancers exhibit a spikey structure which can be reverted an

Externí odkaz: https://doaj.org/article/4bf1f86424d4458c89d66da69cca86c8

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Supplementary Figure S3 from FGFR1-Activated Translation of WNT Pathway Components with Structured 5′ UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation

Autor: Jeffrey M. Rosen, Matthew J. Ellis, Charles M. Perou, Richard E. Lloyd, Joel R. Neilson, Bing Zhang, Yiwen Chen, Kevin P. Roarty, Qianxing Mo, Sung Yun Jung, Anna Malovannaya, Xiang H.-F. Zhang, Peng Zhang, Lucas C. Reineke, Yongchao Dou, Elena B. Kabotyanski, Tuan M. Nguyen

Supplementary Figure S3 shows comprehensive multi-omics correlation analysis and assessment of the magnitude of improvement in inter-omic correlations as the cells switched from a steady state to a dynamic state induced by iFGFR1 activation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4db2d65de752d7372d102d70105c247
https://doi.org/10.1158/0008-5472.22418628.v1

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Supplementary Table S1 from FGFR1-Activated Translation of WNT Pathway Components with Structured 5′ UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation

Supplementary Table S1 provides expression data of RNA, ribosome occupancy and protein used for multi-omics correlation analysis as well as complete lists of TE UP, TE DOWN and background genes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf6babb6a550e69e7b05d100493343e
https://doi.org/10.1158/0008-5472.22418616

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Data from FGFR1-Activated Translation of WNT Pathway Components with Structured 5′ UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation

Cooperativity between WNT and FGF signaling is well documented in embryonic development and cancer progression, but the molecular mechanisms underlying this cross-talk remain elusive. In this study, we interrogated the dynamics of RNA levels, ribosom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ca565f14dd0b6cbd4a46217accb771
https://doi.org/10.1158/0008-5472.c.6510180.v1

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Supplementary Methods and Figure Legends from FGFR1-Activated Translation of WNT Pathway Components with Structured 5′ UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation

Supplementary Methods and Figure Legends provide further details of the study methods and legends for supplementary figures and tables.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7c7fbde78c4a7d9e6de963a2ac6f50
https://doi.org/10.1158/0008-5472.22418619

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