Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Kevin P. McHugh"'
Autor:
Radha Gopal, Egemen Tutuncuoglu, Veli Bakalov, Karla Wasserloos, HuiHua Li, David Lemley, Louis J. DeVito, Nicholas J. Constantinesco, Douglas S. Reed, Kevin J. McHugh, Baskaran Chinnappan, Alexis R. Andreas, Abigail Maloy, Daniel Bain, John F. Alcorn, Bruce R. Pitt, Ata Murat Kaynar
Publikováno v:
Physiological Reports, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract Although zinc deficiency (secondary to malnutrition) has long been considered an important contributor to morbidity and mortality of infectious disease (e.g. diarrhea disorders), epidemiologic data (including randomized controlled trials wit
Externí odkaz:
https://doaj.org/article/24848568926048cabe301806378dc84f
Autor:
Peisen Zhang, Junli Meng, Yingying Li, Chen Yang, Yi Hou, Wen Tang, Kevin J. McHugh, Lihong Jing
Publikováno v:
The Innovation, Vol 2, Iss 4, Pp 100174- (2021)
A vast majority of cancer deaths occur as a result of metastasis. Unfortunately, effective treatments for metastases are currently lacking due to the difficulty of selectively targeting these small, delocalized tumors distributed across a variety of
Externí odkaz:
https://doaj.org/article/087464a30b9148ea87c60af7c3e1b180
Autor:
Helen E Rich, Danielle Antos, Collin C McCourt, Wen Quan Zheng, Louis J Devito, Kevin J McHugh, Radha Gopal, Jieru Wang, John F Alcorn
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0255309 (2021)
BackgroundType III interferon, or interferon lambda (IFNλ) is a crucial antiviral cytokine induced by influenza infection. While IFNλ is important for anti-viral host defense, published data demonstrate that IFNλ is pathogenic during influenza/bac
Externí odkaz:
https://doaj.org/article/164f797b44ad4746969acad593a6ba44
Autor:
Kevin J. McHugh
Publikováno v:
Bioengineering & Translational Medicine, Vol 5, Iss 2, Pp n/a-n/a (2020)
Externí odkaz:
https://doaj.org/article/ecf55b7351eb41ad98f4ec5c128f76a7
Autor:
Brett H. Pogostin, Kevin J. McHugh
Publikováno v:
Bioengineering, Vol 8, Iss 11, p 155 (2021)
Future infectious disease outbreaks are inevitable; therefore, it is critical that we maximize our readiness for these events by preparing effective public health policies and healthcare innovations. Although we do not know the nature of future patho
Externí odkaz:
https://doaj.org/article/88eece1186a845368375618a50e7e78f
Autor:
Kevin J McHugh, Dian Li, Jay C Wang, Leon Kwark, Jessica Loo, Venkata Macha, Sina Farsiu, Leo A Kim, Magali Saint-Geniez
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0216215 (2019)
Although drusen have long been acknowledged as a primary hallmark of dry age-related macular degeneration (AMD) their role in the disease remains unclear. We hypothesize that drusen accumulation increases the barrier to metabolite transport ultimatel
Externí odkaz:
https://doaj.org/article/57ea3bce0b5b4aea8d3330500a8a13de
Autor:
Wellington J Rody, Casey A Chamberlain, Alyssa K Emory-Carter, Kevin P McHugh, Shannon M Wallet, Victor Spicer, Oleg Krokhin, L Shannon Holliday
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219602 (2019)
Extracellular vesicles (EVs) from osteoclasts are important regulators in intercellular communication. Here, we investigated the proteome of EVs from clastic cells plated on plastic (clasts), bone (osteoclasts) and dentin (odontoclasts) by two-dimens
Externí odkaz:
https://doaj.org/article/e425397066b7439e81912a2350493540
Autor:
Radha Gopal, Benjamin Lee, Kevin J. McHugh, Helen E. Rich, Krishnaveni Ramanan, Sivanarayana Mandalapu, Michelle E. Clay, Philip J. Seger, Richard I. Enelow, Michelle L. Manni, Keven M. Robinson, Javier Rangel-Moreno, John F. Alcorn
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Influenza is a common respiratory virus that infects between 5 and 20% of the US population and results in 30,000 deaths annually. A primary cause of influenza-associated death is secondary bacterial pneumonia. We have previously shown that influenza
Externí odkaz:
https://doaj.org/article/c296759483a54f1c982c9edb7a45130c
Autor:
Radha Gopal, Angelico Mendy, Michael A. Marinelli, Lacee J. Richwalls, Philip J. Seger, Shivani Patel, Kevin J. McHugh, Helen E. Rich, Jennifer A. Grousd, Erick Forno, John F. Alcorn
Publikováno v:
Viruses, Vol 11, Iss 6, p 505 (2019)
Influenza virus is among the most common causes of respiratory illness worldwide and can be complicated by secondary bacterial pneumonia, a frequent cause of mortality. When influenza virus infects the lung, the innate immune response is activated, a
Externí odkaz:
https://doaj.org/article/70bb46a450d244358957415554cf76d4
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82865 (2013)
Influenza viruses pose a significant health risk and annually impose a great cost to patients and the health care system. The molecular determinants of influenza severity, often exacerbated by secondary bacterial infection, are largely unclear. We ge
Externí odkaz:
https://doaj.org/article/c056fea55f474c76b786caa432886f2a