Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kevin P. Killeen"'
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 15, Iss 6, Pp 1310-1316 (2019)
Typhax is an investigational typhoid fever vaccine candidate that was GMP manufactured applying Protein Capsular Matrix Vaccine (PCMV) technology. It consists of Vi polysaccharide antigen, derived from S. Typhi, non-covalently entrapped in a glutaral
Externí odkaz:
https://doaj.org/article/fbfd1a19c87b421c8195c1660aafc381
Autor:
Kevin P. Killeen
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 14, Iss 4, Pp 804-806 (2018)
Externí odkaz:
https://doaj.org/article/0c198b54809f445187755b289485e9ac
Autor:
Robert T Cartee, Ann Thanawastien, Thomas J Griffin Iv, John J Mekalanos, Stephan Bart, Kevin P Killeen
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007912 (2020)
BACKGROUND:Typhoid fever remains a significant cause of morbidity and mortality in developing countries especially in children ≤5 years old. Although the widely available unconjugated Vi polysaccharide vaccines are efficacious, they confer limited,
Externí odkaz:
https://doaj.org/article/2a50a6751c374121b9263e76863bbf71
Autor:
Yoshikazu, Honda-Okubo, Robert T, Cartee, Ann, Thanawastien, Jae, Seung Yang, Kevin P, Killeen, Nikolai, Petrovsky
Publikováno v:
Vaccine. 40:4625-4634
Typhax is an investigational typhoid fever vaccine candidate that is comprised of Vi polysaccharide from Salmonella enterica serovar typhi (S. Typhi) non-covalently entrapped in a glutaraldehyde catalyzed, cross-linked α-poly-L-lysine and CRM
Autor:
Rodney K. Tweten, Robert T. Cartee, Laurel A. Haines, Stephen I. Pelton, Ann Thanawastien, Kevin P. Killeen, Kelsey E. Joyce
Publikováno v:
Vaccine
Pneumolysin is a highly conserved, cholesterol-dependent cytolysin that is an important Streptococcus pneumoniae virulence factor and an attractive target for vaccine development. To attenuate pneumolysin toxicity, a genetic toxoid was constructed wi
Autor:
John J. Mekalanos, Kevin P. Killeen, Robert T. Cartee, Thomas J. Griffin, Stephan Bart, Ann Thanawastien
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007912 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background Typhoid fever remains a significant cause of morbidity and mortality in developing countries especially in children ≤5 years old. Although the widely available unconjugated Vi polysaccharide vaccines are efficacious, they confer limited,
Publikováno v:
Hum Vaccin Immunother
Typhax is an investigational typhoid fever vaccine candidate that was GMP manufactured applying Protein Capsular Matrix Vaccine (PCMV) technology. It consists of Vi polysaccharide antigen, derived from S. Typhi, non-covalently entrapped in a glutaral
Autor:
Lawrence J. Thomas, Kevin P. Killeen, Donata R. Sizemore, Elizabeth Warner, Julie A. Lawrence, Kenneth L. Roland
Publikováno v:
Human Vaccines & Immunotherapeutics. 8:371-383
Preclinical studies evaluating plague vaccine candidates have demonstrated that the F1 and V protein antigens of Yersinia pestis confer protection against challenge from virulent strains. Live-attenuated ΔphoP/Q Salmonella typhimurium recombinants w
Autor:
Kevin P Killeen
Publikováno v:
Human Vaccines. 5:667-670
The 2009 World Vaccine Congress (WVC) meeting was held in Chantilly, VA from April 20-23. This is a summary of the ‘Adjuvant and Delivery Technologies’ session chaired by Dr. William Warren of VaxDesign. The WVC ‘Adjuvants and Delivery Technolo
Autor:
Kenneth L. Roland, Lawrence J. Thomas, Kevin P. Killeen, Steven A. Tinge, Sims K. Kochi, Craig J. Rouskey, Cheryl Cloninger
Publikováno v:
Vaccine. 25:8574-8584
Enterotoxigenic Escherichia coli (ETEC) is the leading cause of traveler's diarrhea. The heat-labile (LT) and heat-stable (ST) toxins mediate ETEC induced diarrhea. ETEC strains may express LT, ST, or both LT and ST, with LT-expressing strains accoun