Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kevin P. Keane"'
Autor:
Emily K. Calton, Kevin N. Keane, Raquel Raizel, Jordan Rowlands, Mario J. Soares, Philip Newsholme
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 814-820 (2017)
Background: Vitamin D status [25(OH)D] has recently been reported to be associated with altered cellular bioenergetic profiles of peripheral blood mononuclear cells (PBMCs). No study has tracked the seasonal variation of 25(OH)D and its putative infl
Externí odkaz:
https://doaj.org/article/e7be4ad5fb884680b5f134d7600c9298
Autor:
Rodrigo Carlessi, Younan Chen, Jordan Rowlands, Vinicius F. Cruzat, Kevin N. Keane, Lauren Egan, Cyril Mamotte, Rebecca Stokes, Jenny E. Gunton, Paulo Ivo Homem de Bittencourt, Philip Newsholme
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent mechanisms. S
Externí odkaz:
https://doaj.org/article/caf5cdca187a473db8fc37928e03d4c9
Publikováno v:
Redox Biology, Vol 10, Iss C, Pp 243-250 (2016)
Background: Circulating peripheral blood mononuclear cells (PBMCs) are exposed to metabolic and immunological stimuli that influence their functionality. We hypothesized that prevailing vitamin D status [25(OH)D] would modulate the bioenergetic profi
Externí odkaz:
https://doaj.org/article/63ccef25cd6446fabd67d8b60d6d510a
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
IVF is currently regarded as a successful new technology with the number of IVF children currently well over 8 million worldwide. This has been achieved by an explosive plethora of facilities. However, from its earliest history, IVF has been beset by
Externí odkaz:
https://doaj.org/article/dbe6fcf24d714285a03f107f9c2c181e
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
The role of growth hormone (GH) in human fertility is widely debated with some studies demonstrating improvements in oocyte yield, enhanced embryo quality, and in some cases increased live births with concomitant decreases in miscarriage rates. Howev
Externí odkaz:
https://doaj.org/article/1a0fb023a77f446080f9ff0fa9c042ff
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
The current understanding of human growth hormone (hGH; here GH) action is that the molecule is a 191-amino acid, single-chain polypeptide that is synthesized, stored and secreted by the somatotroph cells within the lateral wings of the anterior pitu
Externí odkaz:
https://doaj.org/article/99f67e206648484388013a0634761e06
Autor:
Iberê Machado Kostrycki, Guilherme Wildner, Yohanna Hannah Donato, Analú Bender dos Santos, Lílian Corrêa Costa Beber, Matias Nunes Frizzo, Mirna Stela Ludwig, Kevin Noel Keane, Vinicius Cruzat, Cláudia Ramos Rhoden, Thiago Gomes Heck
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
Obesity, air pollution, and exercise induce alterations in the heat shock response (HSR), in both intracellular 70 kDa heat shock proteins (iHSP70) and the plasmatic extracellular form (eHSP72). Extra-to-intracellular HSP70 ratio (H-index = eHSP70/iH
Externí odkaz:
https://doaj.org/article/21cfd3f36d13436d9e5303140a5608a9
Autor:
Kevin N. Keane, Peter M. Hinchliffe, Philip K. Rowlands, Gayatri Borude, Shanti Srinivasan, Satvinder S. Dhaliwal, John L. Yovich
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
BackgroundIn vitro fertilization (IVF) patients receive various adjuvant therapies to enhance success rates, but the true benefit is actively debated. Growth hormone (GH) and dehydroepiandrosterone (DHEA) supplementation were assessed in women underg
Externí odkaz:
https://doaj.org/article/31a4e9fcb2e64fd194cca19d59cf8735
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141770 (2015)
Chronic low-grade inflammation accompanies obesity and its related chronic conditions. Both peripheral blood mononuclear cells (PBMCs) and cell lines have been used to study whether vitamin D has immune modulating effects; however, to date a detailed
Externí odkaz:
https://doaj.org/article/cb3b8f2353784562881c61e7a37e7697
Autor:
Giuseppe Verdile, Kevin N. Keane, Vinicius F. Cruzat, Sandra Medic, Miheer Sabale, Joanne Rowles, Nadeeja Wijesekara, Ralph N. Martins, Paul E. Fraser, Philip Newsholme
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent research has provided evidence that insulin resistance and impaired insulin signalling may be
Externí odkaz:
https://doaj.org/article/de65fd2b05df46b59967626a085fe815