Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kevin P. Curran"'
Autor:
Valentin Barsan, Yimei Li, Snehit Prabhu, Christina Baggott, Khanh Nguyen, Holly Pacenta, Christine L. Phillips, Jenna Rossoff, Heather Stefanski, Julie-An Talano, Amy Moskop, Susanne Baumeister, Michael R. Verneris, Gary Douglas Myers, Nicole A. Karras, Stacy Cooper, Muna Qayed, Michelle Hermiston, Prakash Satwani, Christa Krupski, Amy Keating, Vanessa Fabrizio, Vasant Chinnabhandar, Michael Kunicki, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Liora M. Schultz
Publikováno v:
EClinicalMedicine, Vol 65, Iss , Pp 102268- (2023)
Summary: Background: Tisagenlecleucel was approved by the Food and Drug Administration (FDA) in 2017 for refractory B-cell acute lymphoblastic leukemia (B-ALL) and B-ALL in ≥2nd relapse. Outcomes of patients receiving commercial tisagenlecleucel up
Externí odkaz:
https://doaj.org/article/20c0403244324301a828fb1de6d7904b
Autor:
Maya Eylon, Snehit Prabhu, Samuel John, Maxwell J. M. King, Dhruv Bhatt, Kevin J. Curran, Courtney Erickson, Nicole A. Karras, Christine L. Phillips, Prakash Satwani, Michelle Hermiston, Erica Southworth, Susanne H. C. Baumeister, Julie-An Talano, Margaret L. MacMillan, Jenna Rossoff, Challice L. Bonifant, Gary Doug Myers, Rayne H. Rouce, Keri Toner, Timothy A. Driscoll, Emmanuel Katsanis, Dana B. Salzberg, Deborah Schiff, Satiro N. De Oliveira, Christian M. Capitini, Holly L. Pacenta, Thomas Pfeiffer, Niketa C. Shah, Van Huynh, Jodi L. Skiles, Ellen Fraint, Kevin O. McNerney, Troy C. Quigg, Joerg Krueger, John A. Ligon, Vanessa A. Fabrizio, Christina Baggott, Theodore W. Laetsch, Liora M. Schultz
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMediport use as a clinical option for the administration of chimeric antigen receptor T cell (CAR T cell) therapy in patients with B-cell malignancies has yet to be standardized. Concern for mediport dislodgement, cell infiltration, and i
Externí odkaz:
https://doaj.org/article/63c1f7316ab94ecab4e03921e246dcfd
Autor:
Alexandre G. Troullioud Lucas, Jaap Jan Boelens, Susan E. Prockop, Kevin J. Curran, Dorine Bresters, Wouter Kollen, Birgitta Versluys, Marc B. Bierings, Anne Archer, Eric Davis, Elizabeth Klein, Nancy A. Kernan, Caroline A. Lindemans, Andromachi Scaradavou
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundPatients with leukemia relapse after allogeneic hematopoietic cell transplant (HCT) have poor survival due to toxicity and disease progression. A second HCT often offers the only curative treatment.MethodsWe retrospectively reviewed our bi-
Externí odkaz:
https://doaj.org/article/4bbe82594c39483eb049ca274f54e3e9
Autor:
Susan E. Prockop, Aisha Hasan, Ekaterina Doubrovina, Parastoo B. Dahi, Irene Rodriguez-Sanchez, Michael Curry, Audrey Mauguen, Genovefa A. Papanicolaou, Yiqi Su, JinJuan Yao, Maria Arcila, Farid Boulad, Hugo Castro-Malaspina, Christina Cho, Kevin J. Curran, Sergio Giralt, Nancy A. Kernan, Guenther Koehne, Ann Jakubowski, Esperanza Papadopoulos, Miguel-Angel Perales, Ioannis Politikos, Keith Price, Annamalai Selvakumar, Craig S. Sauter, Roni Tamari, Teresa Vizconde, James W. Young, Richard J. O’Reilly
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Background Refractory CMV viremia and disease are associated with significant morbidity and mortality in recipients of hematopoietic stem cell transplant (HCT).Methods In phase I/II trials, we treated 67 subjects for CMV viremia or disease arising af
Externí odkaz:
https://doaj.org/article/c8bff7f8a061422b8ccb6a5d37b43f5a
Autor:
Kenneth Cornetta, Lisa Duffy, Steven A. Feldman, Crystal L. Mackall, Marco L. Davila, Kevin J. Curran, Richard P. Junghans, Jean Yuh Tang, James N. Kochenderfer, Roisin O’Cearbhaill, Gary Archer, Hans-Peter Kiem, Nirali N. Shah, Cindy Delbrook, Rosie Kaplan, Renier J. Brentjens, Isabelle Rivière, Michel Sadelain, Steven A. Rosenberg
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 371-378 (2018)
Replication-competent retrovirus (RCR) is a safety concern for individuals treated with retroviral gene therapy. RCR detection assays are used to detect RCR in manufactured vector, transduced cell products infused into research subjects, and in the r
Externí odkaz:
https://doaj.org/article/d41ec9a65e514c438579bc848efe4243
Autor:
Zheng Liu, Maro J. Kariya, Christopher D. Chute, Amy K. Pribadi, Sarah G. Leinwand, Ada Tong, Kevin P. Curran, Neelanjan Bose, Frank C. Schroeder, Jagan Srinivasan, Sreekanth H. Chalasani
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Defensive behavioral responses can be triggered by predator-released odors. Here, the authors identified the relevant Pristionchus pacificus-released sulfolipid molecules and dissected the neural circuits underlying C. elegans response to this predat
Externí odkaz:
https://doaj.org/article/15b6645a0d3c438aa0f7c65f94dc1b17
Publikováno v:
Molecular Therapy: Oncolytics, Vol 3, Iss C (2016)
T cells can be genetically modified to target tumors through the expression of a chimeric antigen receptor (CAR). Most notably, CAR T cells have demonstrated clinical efficacy in hematologic malignancies with more modest responses when targeting soli
Externí odkaz:
https://doaj.org/article/aa41bb42649f4d75ac05ef63fa675fa4
Autor:
Ada Tong, Kevin P. Curran, Sreekanth H. Chalasani, Neelanjan Bose, Zheng Liu, Jagan Srinivasan, Amy K. Pribadi, Sarah G Leinwand, Frank C. Schroeder, Christopher D. Chute, Maro J. Kariya
Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the interactions between Caenorhabditis elegans and its predator, Pristionchus pacificus, we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac0506815552af034aaf5efc794233b
https://doi.org/10.1101/153056
https://doi.org/10.1101/153056
Autor:
Martin Obst, David C. Ferranti, James M. Kasuboski, Bernhard Goetze, Kevin P. Curran, Claus Burkhardt, James A. J. Fitzpatrick, Yury J. Sigal, Fabian Zeitvogel, Chuong Huynh, Matthew S. Joens, Sreekanth H. Chalasani, Lewis Stern
Publikováno v:
Scientific Reports
Scanning Electron Microscopy (SEM) has long been the standard in imaging the sub-micrometer surface ultrastructure of both hard and soft materials. In the case of biological samples, it has provided great insights into their physical architecture. Ho
Publikováno v:
Invertebrate Neuroscience
Fear, a reaction to a threatening situation, is a broadly adaptive feature crucial to the survival and reproductive fitness of individual organisms. By contrast, anxiety is an inappropriate behavioral response often to a perceived, not real, threat.