Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kevin P Toolan"'
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006922 (2017)
Coordinated cardiomyocyte growth, differentiation, and morphogenesis are essential for heart formation. We demonstrate that the bHLH transcription factors Hand1 and Hand2 play critical regulatory roles for left ventricle (LV) cardiomyocyte proliferat
Externí odkaz:
https://doaj.org/article/f61c97e4181a4256a2650c8546fa46bb
Publikováno v:
American Journal of Ophthalmology Case Reports, Vol 36, Iss , Pp 102108- (2024)
Externí odkaz:
https://doaj.org/article/c15c1821bb7346e88bce7f0ea4c45a66
Publikováno v:
American Journal of Ophthalmology Case Reports, Vol 32, Iss , Pp 101922- (2023)
Purpose: To describe a case of linezolid toxic optic neuropathy in a 71-year-old female and review the relevant literature. Observations: An adult female with progressive, symmetric vision loss was hypothesized to have linezolid toxic optic neuropath
Externí odkaz:
https://doaj.org/article/3aae037c0aee488fa8961998c2699795
Autor:
Marco Osterwalder, Kevin P. Toolan, Beth A. Firulli, Len A. Pennacchio, Anthony B. Firulli, Joshua W. Vincentz
Publikováno v:
Dev Biol
Congenital heart defects (CHDs) affecting the cardiac outflow tract (OFT) constitute a significant cause of morbidity and mortality. The OFT develops from migratory cell populations which include the cardiac neural crest cells (cNCCs) and secondary h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0f63a2490d9f0f4dae0288a4cb4911
https://doi.org/10.1016/j.ydbio.2021.03.011
https://doi.org/10.1016/j.ydbio.2021.03.011
Autor:
Michael Rubart-von der Lohe, Vincent M. Christoffels, Joshua W. Vincentz, Dan E. Arking, Peng Sheng Chen, Nona Sotoodehnia, Beth A. Firulli, Corrie de Gier-de Vries, Kevin P. Toolan, Juyi Wan, Anthony B. Firulli
Publikováno v:
Circ Res
Circulation research, 125(6), 575-589. Lippincott Williams and Wilkins
Circulation research, 125(6), 575-589. Lippincott Williams and Wilkins
Rationale: The ventricular conduction system (VCS) rapidly propagates electrical impulses through the working myocardium of the ventricles to coordinate chamber contraction. GWAS (Genome-wide association studies) have associated nucleotide polymorphi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ee5ff17896b8b9e53d812b716dd834
https://doi.org/10.1161/circresaha.119.315313
https://doi.org/10.1161/circresaha.119.315313
Autor:
Rajani M. George, Ronald M Payne, Loren J. Field, Hongyu Gao, Michael Rubart-von der Lohe, Weinian Shou, Anthony B. Firulli, Wenjun Zhang, Jade Harkin, Beth A. Firulli, Ying Liu, Kevin P. Toolan, Yunlong Liu
Publikováno v:
Cardiovasc Res
AimsTo examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in embryonic and adult myocardium.Methods and resultsHand1 is expressed within the cardiomyocytes of the left ventricle (LV) and myocardial cuff between embryonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4eb9e7a7d5a88d1eee42c91a0d485c
https://doi.org/10.1093/cvr/cvz182
https://doi.org/10.1093/cvr/cvz182
Autor:
Nona Sotoodehnia, Juyi Wan, Corrie de Gier-de Vries, Anthony B. Firulli, Michael Rubart-von der Lohe, Beth A. Firulli, Kevin P. Toolan, Dan E. Arking, Peng Sheng Chen, Vincent M. Christoffels, Joshua W. Vincentz
Publikováno v:
Circulation. 138
The ventricular conduction system (VCS), composed of the His bundle, the left and right bundle branches, and the Purkinje fiber network, rapidly propagates electrical impulses through the ventricles to coordinate chamber contraction. An ECG depicts V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf00331cc15978c2fac9b65b25f62964
https://doi.org/10.1161/circ.138.suppl_1.17134
https://doi.org/10.1161/circ.138.suppl_1.17134
Autor:
Anthony B. Firulli, Alexander G. Robling, Beth A. Firulli, Jade Harkin, Hannah Milliar, Robyn K. Fuchs, Kevin P. Toolan
Publikováno v:
Development (Cambridge, England)
The morphogenesis of the vertebrate limbs is a complex process in which cell signaling and transcriptional regulation coordinate diverse structural adaptations in diverse species. In this study, we examine the consequences of altering Hand1 dimer cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede6d91d6737e7ecdb21b52e1f0d1703
https://doi.org/10.1242/dev.149963
https://doi.org/10.1242/dev.149963
Autor:
Kevin P. Toolan, Hannah Millar, Beth A. Firulli, Santiago Pineda, Jade Harkin, Anthony B. Firulli
Publikováno v:
Cardiovascular research. 113(14)
Aims To test if a human Hand1 frame shift mutation identified in human samples is causative of hypoplastic left heart syndrome (HLHS). Methods and results HLHS is a poorly understood single ventricle congenital heart defect that affects two to three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b41d3b77677474d1e95e26fee514c33
https://pubmed.ncbi.nlm.nih.gov/29016838
https://pubmed.ncbi.nlm.nih.gov/29016838