Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kevin P Grace"'
Autor:
Kevin P Grace, Richard L Horner
Publikováno v:
Frontiers in Neurology, Vol 6 (2015)
Rapid eye movement (REM) sleep - characterized by vivid dreaming, motor paralysis, and heightened neural activity - is one of the fundamental states of the mammalian central nervous system. Initial theories of rapid eye movement (REM) sleep generatio
Externí odkaz:
https://doaj.org/article/5df98fd2dd554ab8aac36bb7052758c3
Autor:
Roberto De Luca, Stefano Nardone, Kevin P. Grace, Anne Venner, Michela Cristofolini, Sathyajit S. Bandaru, Lauren T. Sohn, Dong Kong, Takatoshi Mochizuki, Bianca Viberti, Lin Zhu, Antonino Zito, Thomas E. Scammell, Clifford B. Saper, Bradford B. Lowell, Patrick M. Fuller, Elda Arrigoni
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Sleep and wakefulness is stabilized by a population of orexin-expressing neurons. In this study, the authors demonstrate how these neurons drive arousal by silencing sleep-promoting neurons in the ventrolateral preoptic nucleus.
Externí odkaz:
https://doaj.org/article/0fd72beca5ba4c64b5cd0f002371285b
Autor:
Jackie J. Liu, Kevin P. Grace, Richard L. Horner, Miguel A. Cortez, Yiwen Shao, Zhengping Jia
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-11 (2017)
Abstract Human studies demonstrate that sleep impairment is a concurrent comorbidity of autism spectrum disorders (ASD), but its etiology remains largely uncertain. One of the prominent theories of ASD suggests that an imbalance in synaptic excitatio
Externí odkaz:
https://doaj.org/article/98100b93f8a04ed3b75fea77686d172b
Autor:
David P. White, Luigi Taranto-Montemurro, Ludovico Messineo, Ali Azarbarzin, Rebecca Salant, Kevin P. Grace, Scott A. Sands, D. Andrew Wellman
Publikováno v:
The Journal of Physiology. 596:5163-5173
Key points In most patients with obstructive sleep apnoea (OSA), there is a spontaneous resolution of the breathing disorders during slow wave sleep (SWS) for yet unknown reasons related to non-anatomical factors. Some recently identified forms of ne
Autor:
Kevin P. Grace, Elda Arrigoni, Patrick M. Fuller, Loris L. Ferrari, Anne Venner, Roberto De Luca, Michela Cristofolini
Publikováno v:
Sleep. 44:A31-A31
Introduction Optogenetic and chemogenetic studies have shown that activation of basal forebrain (BF) GABAergic neurons rapidly wakes up mice from non-REM (NREM) sleep. These wake-promoting responses have been attributed to BF GABAergic neurons projec
Publikováno v:
The Journal of Neuroscience. 34:14198-14209
Initial theories of rapid eye movement (REM) sleep generation posited that induction of the state required activation of the pontine subceruleus (SubC) by cholinergic inputs. Although the capacity of cholinergic neurotransmission to contribute to REM
Publikováno v:
Sleep. 37:41-50
Study objectives Obstructive sleep apnea (OSA) is a significant public health problem caused by repeated episodes of upper airway closure that occur only during sleep. Attempts to treat OSA pharmacologically have been unsuccessful because there has n
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 187:311-319
Inhibition of pharyngeal motoneurons accompanies REM sleep and is a cause of hypoventilation and obstructive sleep apnea in humans. One explanation posits that the neurotransmitters glycine and γ-aminobutyric acid are responsible for REM sleep motor
Autor:
Kevin P. Grace, Anh D. Lê, Stephen E. Harding, Richard L. Horner, Laura M. Vecchio, Hattie Liu
Publikováno v:
Journal of Applied Physiology. 108:387-400
Ethanol, one of the most widely used drugs in Western society, worsens obstructive sleep apnea in humans. No studies, however, have distinguished between two primary mechanisms that could mediate suppression of genioglossus (GG) activity with ethanol
Autor:
Kevin P. Grace
Publikováno v:
Proceedings of the National Academy of Sciences. 112
Van Dort et al. (1) used optogenetic activation to demonstrate the capacity of cholinergic neurons in the laterodorsal and pedunculopontine tegmental nuclei (LDT and PPT, respectively) to induce rapid eye movement (REM) sleep. The authors submit that