Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Kevin P, Maresca"'
Autor:
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca, John Litchfield, Timothy McCarthy, Richard E. Carson, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a
Externí odkaz:
https://doaj.org/article/0b2d2f0ac72047df80a3f5d00a8935c1
Autor:
Yuichi Wakabayashi, Per Stenkrona, Ryosuke Arakawa, Xuefeng Yan, Maia G. Van Buskirk, Madeline D. Jenkins, Jose A. Montero Santamaria, Kevin P. Maresca, Akihiro Takano, Jeih-San Liow, Thomas A. Chappie, Andrea Varrone, Sangram Nag, Lei Zhang, Zoë A. Hughes, Christopher J. Schmidt, Shawn D. Doran, Andrew Mannes, Paolo Zanotti-Fregonara, Maarten Ooms, Cheryl L. Morse, Sami S. Zoghbi, Christer Halldin, Victor W. Pike, Robert B. Innis
Publikováno v:
Journal of Nuclear Medicine. 63:1919-1924
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61c7d547cbcb5109418140c2b1e19428
https://doi.org/10.2967/jnumed.122.263838
https://doi.org/10.2967/jnumed.122.263838
Autor:
Rachel J Roth Flach, Chunyan Su, Eliza Bollinger, Christian Cortes, Andrew W Robertson, Alan C Opsahl, Timothy M Coskran, Kevin P Maresca, Edmund J Keliher, Phillip D Yates, Albert M Kim, Amit S Kalgutkar, Leonard Buckbinder
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214150 (2019)
Myeloperoxidase (MPO) is a highly abundant protein within the neutrophil that is associated with lipoprotein oxidation, and increased plasma MPO levels are correlated with poor prognosis after myocardial infarct. Thus, MPO inhibitors have been develo
Externí odkaz:
https://doaj.org/article/1d4d82c1feff4fad91bb96d03ddfbae9
Autor:
Eve H. Pickering, Keith Kobylarz, Jianqing Chen, Jonathan Golas, Ohad Ilovich, Lindsay King, Sripad Ram, Kevin P. Maresca, Timothy J. McCarthy, Laigao Chen, James S. Hardwick, Amira Hussein, Jatin Narula, Edward Rosfjord, Anand Giddabasappa, Edmund J. Keliher, Ian D. Wilson, Adam Root, David Schaer, Divya Mathur, Paul A. Rejto, Kevin Staton
Publikováno v:
Molecular Imaging and Biology
Purpose A sensitive and specific imaging biomarker to monitor immune activation and quantify pharmacodynamic responses would be useful for development of immunomodulating anti-cancer agents. PF-07062119 is a T cell engaging bispecific antibody that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2d5a9aa5061121cdb634e6b8a7982c
http://europepmc.org/articles/PMC8578158
http://europepmc.org/articles/PMC8578158
Autor:
T. Lee Collier PhD, Kevin P. Maresca PhD, Marc D. Normandin PhD, Paul Richardson PhD, Timothy J. McCarthy PhD, Steven H. Liang PhD, Rikki N. Waterhouse PhD, Neil Vasdev PhD
Publikováno v:
Molecular Imaging, Vol 16 (2017)
The Massachusetts General Hospital Radiochemistry Program, in collaboration with Pfizer, has developed unique 11 C and 18 F-labeling strategies to synthesize isotopologs of lorlatinib (PF-06463922) which is undergoing phase III clinical trial investi
Externí odkaz:
https://doaj.org/article/27b95e925c124ac8b0c0adf8168291a3
Autor:
Akihiro Takano, Nahid Amini, Edmund J. Keliher, Christer Halldin, Lei Zhang, Richard E. Carson, Patrick Trapa, Sangram Nag, Ryosuke Arakawa, Deane M. Nason, Kevin P. Maresca, Zhisheng Jia, John Litchfield, Tarek A. Samad, Christopher Ryan Butler, Justin R. Piro, Timothy J. McCarthy, Deborah L. Smith, Steve O’Neil, Kari R. Fonseca
Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b463c48140050426b0c96d37c2ff81
https://doi.org/10.21203/rs.3.rs-510615/v2
https://doi.org/10.21203/rs.3.rs-510615/v2
Autor:
Ryosuke, Arakawa, Akihiro, Takano, Sangram, Nag, Zhisheng, Jia, Nahid, Amini, Kevin P, Maresca, Lei, Zhang, Edmund J, Keliher, Christopher R, Butler, Justin R, Piro, Tarek A, Samad, Deborah, Smith, Deane, Nason, Steve, O'Neil, Patrick, Trapa, Kari R, Fonseca, John, Litchfield, Timothy, McCarthy, Richard E, Carson, Christer, Halldin
Publikováno v:
EJNMMI research. 12(1)
Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [Seven cynomolgus monkeys were enrolled for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a98c606e14bcd5e9f645c4b6b371c6bf
https://pubmed.ncbi.nlm.nih.gov/35244788
https://pubmed.ncbi.nlm.nih.gov/35244788
Autor:
Dennis O. Scott, Spiros Liras, Roger B. Ruggeri, Heather Eng, Adam S. Kamlet, Ryosuke Arakawa, David W. Piotrowski, Robert Dullea, Christopher T. Salatto, Karen Atkinson, Michael W. Bolt, Anne-Marie R. Dechert-Schmitt, Paul DaSilva-Jardine, Allyn T. Londregan, Brian Raymer, Kenneth Dahl, Daniel P. Canterbury, Donna N. Petersen, Paula M. Loria, Chris Limberakis, Emi Kimoto, Kim F. McClure, Kevin Beaumont, Liuqing Wei, Akihiro Takano, Kevin P. Maresca, Jun Xiao, Amanda King-Ahmad, Christer Halldin, Benjamin Reidich, Jeffrey R. Chabot
Publikováno v:
Angewandte Chemie International Edition. 56:16218-16222
Targeting of the human ribosome is an unprecedented therapeutic modality with a genome-wide selectivity challenge. A liver-targeted drug candidate is described that inhibits ribosomal synthesis of PCSK9, a lipid regulator considered undruggable by sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284063acd5910c34eb16ba576995a299
https://doi.org/10.1002/anie.201708744
https://doi.org/10.1002/anie.201708744
Autor:
Christopher Ryan Butler, Timothy J. McCarthy, Ryosuke Arakawa, Deborah L. Smith, Klaas Schildknegt, Justin R. Piro, Lei Zhang, Kevin P. Maresca, Laura A. McAllister, Deane M. Nason, Zhisheng Jia, Sangram Nag, Akihiro Takano, Tarek A. Samad, Christer Halldin, Anabella Villalobos, Steven Victor O'neil, Patrick Trapa
Publikováno v:
Journal of medicinal chemistry. 62(18)
Monoacylglycerol lipase (MAGL), a serine hydrolase extensively expressed throughout the brain, serves as a key gatekeeper regulating the tone of endocannabinoid signaling. Preclinically, inhibition of MAGL is known to provide therapeutic benefits for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf9e513dd3ea64b1d4e6e3ab52c34c1
https://pubmed.ncbi.nlm.nih.gov/31483137
https://pubmed.ncbi.nlm.nih.gov/31483137
Autor:
Gregory R. Wojtkiewicz, John W. Chen, Negin Jalali Motlagh, Cuihua Wang, Kevin P. Maresca, Edmund J. Keliher, Matthias W.G. Zeller, Matthias Nahrendorf, Hye-Yeong Kim, Jianqing Chen, Maaz S. Ahmed, Aaron D. Aguirre, Leonard Buckbinder
Myeloperoxidase (MPO) is a critical proinflammatory enzyme implicated in cardiovascular, neurological, and rheumatological diseases. Emerging therapies targeting inflammation have raised interest in tracking MPO activity in patients. We describe 18 F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddc10e5d3f11439e614ed43d3bf2022
https://europepmc.org/articles/PMC6575581/
https://europepmc.org/articles/PMC6575581/