Výsledky vyhledávání - "Kevin Oberhausen"

Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi's Sarcoma-Associated Herpesvirus

Autor: Walid A. M. Elgaher, Christine Walt, Thomas F. Schulz, Kevin Oberhausen, Valentin Jakob, Martin Empting, Philine Kirsch

Publikováno v: ACS chemical biology

With the aim to develop novel antiviral agents against Kaposi's Sarcoma Herpesvirus (KSHV), we are targeting the latency-associated nuclear antigen (LANA). This protein plays an important role in viral genome maintenance during latent infection. LANA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37df79907374f794822a7f0988d4701
https://pubmed.ncbi.nlm.nih.gov/31944659

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Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8

Autor: Saskia C. Stein, Valentin Jakob, Martin Empting, Philine Kirsch, Kevin Oberhausen, Thomas F. Schulz, Ivano Cucarro

Publikováno v: Journal of medicinal chemistry

The latency-associated nuclear antigen (LANA) is required for latent replication and persistence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. It acts via replicating and tethering the virus episome to the host chromatin and exerts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ab45ba064fa29b5f55d7009f9f856f
https://pubmed.ncbi.nlm.nih.gov/30888817

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