Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Kevin O. Saunders"'
Autor:
Rory Henderson, Kara Anasti, Kartik Manne, Victoria Stalls, Carrie Saunders, Yishak Bililign, Ashliegh Williams, Pimthada Bubphamala, Maya Montani, Sangita Kachhap, Jingjing Li, Chuancang Jaing, Amanda Newman, Derek W. Cain, Xiaozhi Lu, Sravani Venkatayogi, Madison Berry, Kshitij Wagh, Bette Korber, Kevin O. Saunders, Ming Tian, Fred Alt, Kevin Wiehe, Priyamvada Acharya, S. Munir Alam, Barton F. Haynes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Vaccine development targeting rapidly evolving pathogens such as HIV-1 requires induction of broadly neutralizing antibodies (bnAbs) with conserved paratopes and mutations, and in some cases, the same Ig-heavy chains. The current trial-and-e
Externí odkaz:
https://doaj.org/article/e26ccce74e0d4f98a02f926d12e62296
Autor:
A. Brenda Kapingidza, Daniel J. Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Dieter Mielke, Lu Xiaozhi, Qi Yin, Andrew Foulger, Rob Parks, Maggie Barr, Amanda Newman, Alexandra Schäfer, Amanda Eaton, Justine Mae Flores, Austin Harner, Nicholas J. Catanzaro, Michael L. Mallory, Melissa D. Mattocks, Christopher Beverly, Brianna Rhodes, Katayoun Mansouri, Elizabeth Van Itallie, Pranay Vure, Brooke Dunn, Taylor Keyes, Sherry Stanfield-Oakley, Christopher W. Woods, Elizabeth A. Petzold, Emmanuel B. Walter, Kevin Wiehe, Robert J. Edwards, David C. Montefiori, Guido Ferrari, Ralph Baric, Derek W. Cain, Kevin O. Saunders, Barton F. Haynes, Mihai L. Azoitei
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike protein, which continually mutates to escape acquired immunity. Other regions in the spike S2 subunit, such as the stem helix and the segment encompassi
Externí odkaz:
https://doaj.org/article/f7c3c671d32d475aacf1c3a48887812f
Autor:
Rory Henderson, Ye Zhou, Victoria Stalls, Kevin Wiehe, Kevin O. Saunders, Kshitij Wagh, Kara Anasti, Maggie Barr, Robert Parks, S. Munir Alam, Bette Korber, Barton F. Haynes, Alberto Bartesaghi, Priyamvada Acharya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Antibody affinity maturation enables adaptive immune responses to a wide range of pathogens. In some individuals broadly neutralizing antibodies develop to recognize rapidly mutating pathogens with extensive sequence diversity. Vaccine desig
Externí odkaz:
https://doaj.org/article/a0c3383f4920484ea23242df323c4d69
Autor:
Dapeng Li, David R. Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L. Sutherland, Esther Lee, Robert Parks, Dieter Mielke, Whitney Edwards, Amanda Newman, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Matthew Gagne, Daniel C. Douek, C. Todd DeMarco, Thomas N. Denny, Thomas H. Oguin, Alecia Brown, Wes Rountree, Yunfei Wang, Katayoun Mansouri, Robert J. Edwards, Guido Ferrari, Gregory D. Sempowski, Amanda Eaton, Juanjie Tang, Derek W. Cain, Sampa Santra, Norbert Pardi, Drew Weissman, Mark A. Tomai, Christopher B. Fox, Ian N. Moore, Hanne Andersen, Mark G. Lewis, Hana Golding, Robert Seder, Surender Khurana, Ralph S. Baric, David C. Montefiori, Kevin O. Saunders, Barton F. Haynes
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors have previously demonstrated the neutralising capacity of their nanoparticle vaccine, as well as showing protection of non-human primates from SARS-CoV-2 WA-1 infection. In this work, they investigate the ability of their vaccine candidat
Externí odkaz:
https://doaj.org/article/b08586c46f7c4fa6b00bfd070a9caed1
Autor:
Bhavna Hora, Hui Li, Xiaoying Shen, Mitchell Martin, Yue Chen, Madison Berry, Tyler Evangelous, Andrew N. Macintyre, Aria Arus-Altuz, Shuyi Wang, Ajay Singh, Chengyan Zhao, Nicole De Naeyer, Todd DeMarco, Cindy Kuykendall, Thaddeus Gurley, Kevin O. Saunders, Thomas Denny, M. Anthony Moody, John Misamore, Mark G. Lewis, Kevin Wiehe, Derek W. Cain, David C. Montefiori, George M. Shaw, Wilton B. Williams
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112255- (2023)
Summary: Infants and children infected with human immunodeficiency virus (HIV)-1 have been shown to develop neutralizing antibodies (nAbs) against heterologous HIV-1 strains, characteristic of broadly nAbs (bnAbs). Thus, having a neonatal model for t
Externí odkaz:
https://doaj.org/article/7dce7418af584710aa80977788fdbcd6
Autor:
Dapeng Li, Simon Brackenridge, Lucy C. Walters, Olivia Swanson, Karl Harlos, Daniel Rozbesky, Derek W. Cain, Kevin Wiehe, Richard M. Scearce, Maggie Barr, Zekun Mu, Robert Parks, Max Quastel, Robert J. Edwards, Yunfei Wang, Wes Rountree, Kevin O. Saunders, Guido Ferrari, Persephone Borrow, E. Yvonne Jones, S. Munir Alam, Mihai L. Azoitei, Geraldine M. Gillespie, Andrew J. McMichael, Barton F. Haynes
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
The identification and structural analysis of HLA-E-VL9-targeting antibodies that block a natural killer (NK) cell receptor pathway and regulate NK function in vitro.
Externí odkaz:
https://doaj.org/article/059bf3a2d5d44706ba2a0a0de0b49e26
Autor:
Frederic Bibollet-Ruche, Ronnie M. Russell, Wenge Ding, Weimin Liu, Yingying Li, Kshitij Wagh, Daniel Wrapp, Rumi Habib, Ashwin N. Skelly, Ryan S. Roark, Scott Sherrill-Mix, Shuyi Wang, Juliette Rando, Emily Lindemuth, Kendra Cruickshank, Younghoon Park, Rachel Baum, John W. Carey, Andrew Jesse Connell, Hui Li, Elena E. Giorgi, Ge S. Song, Shilei Ding, Andrés Finzi, Amanda Newman, Giovanna E. Hernandez, Emily Machiele, Derek W. Cain, Katayoun Mansouri, Mark G. Lewis, David C. Montefiori, Kevin J. Wiehe, S. Munir Alam, I-Ting Teng, Peter D. Kwong, Raiees Andrabi, Laurent Verkoczy, Dennis R. Burton, Bette T. Korber, Kevin O. Saunders, Barton F. Haynes, Robert J. Edwards, George M. Shaw, Beatrice H. Hahn
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT HIV-1 and its SIV precursors share a broadly neutralizing antibody (bNAb) epitope in variable loop 2 (V2) at the envelope glycoprotein (Env) trimer apex. Here, we tested the immunogenicity of germ line-targeting versions of a chimpanzee SIV
Externí odkaz:
https://doaj.org/article/3b93383f6dad4c28967afedad78671dd
Autor:
Daryll Vanover, Chiara Zurla, Hannah E. Peck, Nichole Orr‐Burks, Jae Yeon Joo, Jackelyn Murray, Nathan Holladay, Ryan A. Hobbs, Younghun Jung, Lorena C. S. Chaves, Laura Rotolo, Aaron W. Lifland, Alicia K. Olivier, Dapeng Li, Kevin O. Saunders, Gregory D. Sempowski, James E. Crowe Jr., Barton F. Haynes, Eric R. Lafontaine, Robert J. Hogan, Philip J. Santangelo
Publikováno v:
Advanced Science, Vol 9, Iss 34, Pp n/a-n/a (2022)
Abstract Despite the success of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) vaccines, there remains a clear need for new classes of preventatives for respiratory viral infections due to vaccine hesitancy, lack of sterilizing im
Externí odkaz:
https://doaj.org/article/ecf03feec815403cb0b70263213107be
Autor:
Chelsea N. Fries, Jui-Lin Chen, Maria L. Dennis, Nicole L. Votaw, Joshua Eudailey, Brian E. Watts, Kelly M. Hainline, Derek W. Cain, Richard Barfield, Cliburn Chan, M. Anthony Moody, Barton F. Haynes, Kevin O. Saunders, Sallie R. Permar, Genevieve G. Fouda, Joel H. Collier
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract A major challenge in developing an effective vaccine against HIV-1 is the genetic diversity of its viral envelope. Because of the broad range of sequences exhibited by HIV-1 strains, protective antibodies must be able to bind and neutralize
Externí odkaz:
https://doaj.org/article/9b1d282b3398438e8effddf57c228cf2
Autor:
Edmund G. Wee, Nathifa A. Moyo, Kevin O. Saunders, Celia LaBranche, Filippo Donati, Silvia Capucci, Robert Parks, Nicola Borthwick, Zara Hannoun, David C. Montefiori, Barton F. Haynes, Tomáš Hanke
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 490- (2022)
Externí odkaz:
https://doaj.org/article/726b4ac73ba5410185fee5e98d031359