Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kevin O. Childress"'
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Clostridioides difficile is a Gram-positive bacterium that can cause mild to severe diarrhea, inflammation, and colonic tissue damage in animal hosts. Symptoms of the disease can be attributed to the activity of toxin B (TcdB) secreted by C.
Externí odkaz:
https://doaj.org/article/dff8cf7d0a5a476c9c8025648277e4fe
Autor:
F Christopher Peritore-Galve, John A Shupe, Rory J Cave, Kevin O Childress, M Kay Washington, Sarah A Kuehne, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010323 (2022)
Clostridioides difficile infection (CDI) is the leading cause of nosocomial diarrhea and pseudomembranous colitis in the USA. In addition to these symptoms, patients with CDI can develop severe inflammation and tissue damage, resulting in life-threat
Externí odkaz:
https://doaj.org/article/53681cccf54a48f9aac596fac3673cfc
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007153 (2018)
To cause disease, Clostridioides (Clostridium) difficile must resist killing by innate immune effectors in the intestine, including the host antimicrobial peptide, cathelicidin (LL-37). The mechanisms that enable C. difficile to adapt to the intestin
Externí odkaz:
https://doaj.org/article/3c874788b5b046e0aafee0f84c85ff38
Autor:
Dena Lyras, John A. Shupe, Jaime L. Jensen, Michael J Sheedlo, Ashleigh P. Rogers, Sarah C. Bloch, Steven J. Mileto, Melanie L. Hutton, Simon Wilkins, Kevin O. Childress, Genevieve Kerr, D. Borden Lacy, Rebekah Engel, Paul J. McMurrick, Thierry Jarde, Katja Horvay, Tracey J. Flores, Helen E. Abud
Publikováno v:
Proc Natl Acad Sci U S A
Gastrointestinal infections often induce epithelial damage that must be repaired for optimal gut function. While intestinal stem cells are critical for this regeneration process [R. C. van der Wath, B. S. Gardiner, A. W. Burgess, D. W. Smith, PLoS On
Autor:
F. Christopher Peritore-Galve, Audrey K. Thomas, Heather K. Kroh, John A. Shupe, M. Kay Washington, Sarah C. Bloch, Erin N. Laubacher, D. Borden Lacy, Kevin O. Childress, Robert J. Coffey, Nicholas O. Markham
Publikováno v:
Infection and Immunity. 89
Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly k
Autor:
Nicholas O, Markham, Sarah C, Bloch, John A, Shupe, Erin N, Laubacher, Audrey K, Thomas, Heather K, Kroh, Kevin O, Childress, F Christopher, Peritore-Galve, M Kay, Washington, Robert J, Coffey, D Borden, Lacy
Publikováno v:
Infect Immun
Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly k
Autor:
Kevin O. Childress, Shonna M. McBride, Sarah E. Anderson, Adrianne N. Edwards, Kathryn L. Nawrocki, Emily C. Woods
Publikováno v:
Infection and Immunity. 84:3434-3444
The formation of spores is critical for the survival of Clostridium difficile outside the host gastrointestinal tract. Persistence of C. difficile spores greatly contributes to the spread of C. difficile infection (CDI), and the resistance of spores
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 8, p e1007153 (2018)
PLoS Pathogens, Vol 14, Iss 8, p e1007153 (2018)
To cause disease, Clostridioides (Clostridium) difficile must resist killing by innate immune effectors in the intestine, including the host antimicrobial peptide, cathelicidin (LL-37). The mechanisms that enable C. difficile to adapt to the intestin
Autor:
Emily C. Woods, Kevin O. Childress, Adrianne N. Edwards, Shonna M. McBride, Ricardo A. Pascual, Kathryn L. Nawrocki
Clostridium difficile is an anaerobic, Gram-positive pathogen that causes severe gastrointestinal disease in humans and other mammals. C. difficile is notoriously difficult to work with and, until recently, few tools were available for genetic manipu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0f6deb7b297234cad9be20724b3d12
https://europepmc.org/articles/PMC4385412/
https://europepmc.org/articles/PMC4385412/
Autor:
Egbert Hoiczyk, David M. Zuckerman, Amanda R Pendleton, Michka Sharpe, Susanna Brantley, Kevin O. Childress, Christie Chen
Publikováno v:
BMC Veterinary Research
Background Infectious bronchitis virus (IBV) is a pathogenic chicken coronavirus. Currently, vaccination against IBV is only partially protective; therefore, better preventions and treatments are needed. Plants produce antimicrobial secondary compoun