Muddy Waters: Refining the Way forward for the 'Sustainability Science' of Socio-Hydrogeology

Autor: Paul Hynds, Shane Regan, Luisa Andrade, Simon Mooney, Kevin O’Malley, Stephanie DiPelino, Jean O’Dwyer

Publikováno v: Water, Vol 10, Iss 9, p 1111 (2018)

The trouble with groundwater is that despite its critical importance to global water supplies, it frequently attracts insufficient management attention relative to more visible surface water sources, irrespective of regional climate, socioeconomic pr

Externí odkaz: https://doaj.org/article/7251ed46040e41668071ced8cc73cef8

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132)

Autor: Yan Shi, Ying Wang, Wei Meng, Robert P. Brigance, Denis E. Ryono, Scott Bolton, Hao Zhang, Sean Chen, Rebecca Smirk, Shiwei Tao, Joseph A. Tino, Kristin N. Williams, Richard Sulsky, Laura Nielsen, Bruce Ellsworth, Michael K. Y. Wong, Jung-Hui Sun, Leslie W. Leith, Dawn Sun, Dauh-Rurng Wu, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Bang-Chi Chen, Aiying Wang, Helen G. Fuentes-Catanio, Lori Kunselman, Michael Cap, Jacob Zalaznick, Xiaohui Ma, Heng Liu, Joseph R. Taylor, Rachel Zebo, Beverly Jones, Stephen Kalinowski, Joann Swartz, Ada Staal, Kevin O’Malley, Lisa Kopcho, Jodi K. Muckelbauer, Stanley R. Krystek, Steven A. Spronk, Jovita Marcinkeviciene, Gerry Everlof, Xue-Qing Chen, Carrie Xu, Yi-Xin Li, Robert A. Langish, Yanou Yang, Qi Wang, Kamelia Behnia, Aberra Fura, Evan B. Janovitz, Nicola Pannacciulli, Steven Griffen, Bradley A. Zinker, John Krupinski, Mark Kirby, Jean Whaley, Robert Zahler, Joel C. Barrish, Jeffrey A. Robl, Peter T. W. Cheng

Publikováno v: Journal of Medicinal Chemistry. 65:4291-4317

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc68196d2f5ecc2fc360366195341ffb
https://doi.org/10.1021/acs.jmedchem.1c02110

Things We Do for No Reason™: Routine pretreatment with a P2Y12 receptor inhibitor before invasive coronary angiography for patients with a non-ST elevation acute coronary syndrome

Autor: Kevin O'Malley, Yoseob Joseph Hwang, Jeffrey Trost, Leonard Feldman

Publikováno v: Journal of hospital medicineREFERENCES.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6faf41f3be14353acb63c8b8c4d5f55
https://pubmed.ncbi.nlm.nih.gov/35920593

Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage

Autor: Charu Chaudhry, Ping Zhang, Kyoung S. Kim, William J. Pitts, Cornelius Lyndon A M, Lynn M. Abell, Hart Amy C, Kevin O’Malley, Junqing Guo, Brian Carpenter, Hao Lu, Ramesh Padmanabha, Patrick J. Shaw, Mertzman Michael E, Kevin Kish, Andrew E Douglas, Matthew Pokross, John E. Macor, Deepa Calambur, Carolyn A. Weigelt

Publikováno v: ACS Med Chem Lett

[Image: see text] Necroptosis has been implicated in a variety of disease states, and RIPK3 is one of the kinases identified to play a critical role in this signaling pathway. In an effort to identify RIPK3 kinase inhibitors with a novel profile, mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2ff1dc1b611e09babd108893b9d371
https://doi.org/10.1021/acsmedchemlett.9b00065

Gender-Related Differences in Flood Risk Perception and Behaviours among Private Groundwater Users in the Republic of Ireland

Autor: Eoin O'Neill, Kevin O'Malley, Cillian P. McDowell, Paul Hynds, Jean O'Dwyer, Luisa Andrade

Publikováno v: International Journal of Environmental Research and Public Health
Articles
International Journal of Environmental Research and Public Health, Vol 17, Iss 6, p 2072 (2020)
Volume 17
Issue 6

Extreme weather events including flooding can have severe personal, infrastructural, and economic consequences, with recent evidence pointing to surface flooding as a pathway for the microbial contamination of private groundwater supplies. There is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcf9b3b0858a95be578b856de16c495
https://pubmed.ncbi.nlm.nih.gov/32245013