Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kevin N. Cobley"'
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :21-25
A racemic synthesis of two diastereoisomeric α-benzyloxycarbonylamino substituted trans-fused bicyclic lactams (4 and 5), was achieved from cyclopentene oxide. These lactams are useful intermediates to investigate the possibility of using a trans-la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0f5aee6c93183eb7ee09a13587b4b1a
https://doi.org/10.1039/b007286i
https://doi.org/10.1039/b007286i
Autor:
Helen Taylor, R. C. Bethell, Alan J. Wonacott, Anne Cleasby, Andrew R. Whittington, Peter M. Colman, Tadeusz Skarzynski, Jose Varghese, Jan Scicinski, Steven L. Sollis, O.M. Singh, Peter C. Cherry, Paul W. Smith, Neil Taylor, Kevin N. Cobley, Peter D. Howes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2931-2936
The structure-activity relationships of a series of 4-amino and guanidino-4H-pyran-2-carboxylic acid 6-carboxamides are described. These compounds represent a new class of inhibitor of influenza sialidases and are particularly active against influenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f63b36b36a33bcb4ad4346f74168bdd3
https://doi.org/10.1016/s0960-894x(96)00542-2
https://doi.org/10.1016/s0960-894x(96)00542-2
Autor:
Gavin A.C. Chung, Paul W. Smith, Mike R. Wood, Ken Duncan, Albert Jaxa Chamiec, Peter D. Howes, Andrew R. Whittington, Kevin N. Cobley
Publikováno v:
The Journal of Antibiotics. 48:73-82
A series of cephalosporins containing a novel 7-[2-(Z)-(2-amino-thiazol-4- yl)-3-(dimethoxy-phosphoryl)-acryloylamino] group were prepared and their antibacterial activity measured against a range of pathogens. In general the compounds displayed a br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cf8f8e3b73e0a759a971665d1308c0
https://doi.org/10.7164/antibiotics.48.73
https://doi.org/10.7164/antibiotics.48.73
Autor:
Duncan S. Holmes, Richard Storer, Ian R. Clemens, John Kitchin, David Cedric Humber, D. C. Orr, I. L. Paternoster, Kevin N. Cobley, Binakumari Patel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:503-508
The synthesis and enzyme activity of linker modified, dimeric, penicillin derived inhibitors is described. Variation of the linker group enabled beneficial interaction with the catalytic aspartates, however, this was offset by disruption of the origi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69d6a4c0911ee97d8f7a9a52d201add2
https://doi.org/10.1016/s0960-894x(01)81216-6
https://doi.org/10.1016/s0960-894x(01)81216-6
Autor:
Richard Storer, D. C. Orr, Malcolm Peter Weir, D. C. Humber, Nicholas Cammack, Jonathan A. V. Coates, Kevin N. Cobley, Gordon G. Weingarten
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1c5282c3bbe789651a256697afc9bc0
https://doi.org/10.1002/chin.199252185
https://doi.org/10.1002/chin.199252185
Autor:
John Saunders, P. G. Wyatt, R. Storer, Mark James Bamford, Kevin N. Cobley, D. C. Orr, N.M. Gray, Michael M. Hann, Gordon G. Weingarten, B. E. V. Shenoy, Derek N. Evans, R. C. Bethell, D. C. Humber, Nicholas Cammack
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8229869a96809563d626b2114271b9eb
https://doi.org/10.1002/chin.199503261
https://doi.org/10.1002/chin.199503261
Publikováno v:
ChemInform. 32
A racemic synthesis of two diastereoisomeric α-benzyloxycarbonylamino substituted trans-fused bicyclic lactams (4 and 5), was achieved from cyclopentene oxide. These lactams are useful intermediates to investigate the possibility of using a trans-la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b07c7a77249ff6230aa9106d29e76b6c
https://doi.org/10.1002/chin.200123202
https://doi.org/10.1002/chin.200123202
Autor:
D.S. Holmes, D. C. Orr, Richard C. Bethell, R. Potter, S. Madar, Kevin N. Cobley, N.M. Gray, David Cedric Humber, C.R. Penn, Gordon G. Weingarten, J.M. Cameron, N. Cammack
Publikováno v:
Analytical biochemistry. 216(1)
In order to identify a suitable peptide substrate for human immunodeficiency virus-1 (HIV-1) proteinase, a range of peptides from various cleavage sites within the gag-pol polyprotein were assayed by HPLC for specific cleavage. The peptide with the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a722188cadd4d98a32339fe8f5a785c
https://pubmed.ncbi.nlm.nih.gov/8135370
https://pubmed.ncbi.nlm.nih.gov/8135370