Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kevin N Lu"'
Autor:
Chunhui Cai, Gregory F Cooper, Kevin N Lu, Xiaojun Ma, Shuping Xu, Zhenlong Zhao, Xueer Chen, Yifan Xue, Adrian V Lee, Nathan Clark, Vicky Chen, Songjian Lu, Lujia Chen, Liyue Yu, Harry S Hochheiser, Xia Jiang, Q Jane Wang, Xinghua Lu
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 7, p e1007088 (2019)
Cancer is mainly caused by somatic genome alterations (SGAs). Precision oncology involves identifying and targeting tumor-specific aberrations resulting from causative SGAs. We developed a novel tumor-specific computational framework that finds the l
Externí odkaz:
https://doaj.org/article/cb1f5e3c7c854cdfa78c3c6d4d695e50
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 8, p e1004257 (2015)
An important goal of cancer genomic research is to identify the driving pathways underlying disease mechanisms and the heterogeneity of cancers. It is well known that somatic genome alterations (SGAs) affecting the genes that encode the proteins with
Externí odkaz:
https://doaj.org/article/c4a748034e9c4b0ca7ecdde9b29b91c9
Autor:
Andrei L. Turinsky, Pouria Mashouri, Michael Brudno, Sanaa Choufani, Da Liu, Daniel Min, Rosanna Weksberg, Kevin N. Lu
Publikováno v:
Human mutationREFERENCES. 41(10)
Epigenetic processes play a key role in regulating gene expression. Genetic variants that disrupt chromatin-modifying proteins are associated with a broad range of diseases, some of which have specific epigenetic patterns, such as aberrant DNA methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03348de3d6b21e2afaf76d5a04aeb5d
https://pubmed.ncbi.nlm.nih.gov/32623772
https://pubmed.ncbi.nlm.nih.gov/32623772
Autor:
Xia Jiang, Xiaojun Ma, Kevin N. Lu, Songjian Lu, Chunhui Cai, Harry Hochheiser, Gregory F. Cooper, Shuping Xu, Zhenlong Zhao, Adrian V. Lee, Lujia Chen, Liyue Yu, Vicky Ping Chen, Nathan L. Clark, Yifan Xue, Q. Jane Wang, Xinghua Lu, Xueer Chen
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 15, Iss 7, p e1007088 (2019)
PLoS Computational Biology, Vol 15, Iss 7, p e1007088 (2019)
Cancer is mainly caused by somatic genome alterations (SGAs). Precision oncology involves identifying and targeting tumor-specific aberrations resulting from causative SGAs. We developed a novel tumor-specific computational framework that finds the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c4bc775862065b5e64deb64462ced6
https://pubmed.ncbi.nlm.nih.gov/31276486
https://pubmed.ncbi.nlm.nih.gov/31276486
Autor:
Xinghua Lu, Kevin N. Lu, Panayiotis V. Benos, Hatice U. Osmanbeyoglu, Claudia Coronnello, Steffi Oesterreich, Roger Day
Publikováno v:
Nucleic Acids Research
Estrogen regulates over a thousand genes, with an equal number of them being induced or repressed. The distinct mechanisms underlying these dual transcriptional effects remain largely unknown. We derived comprehensive views of the transcription machi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f6c06d280bf85ff4776d166fa28eee
https://doi.org/10.1093/nar/gkt586
https://doi.org/10.1093/nar/gkt586