Výsledky vyhledávání - "Kevin Moulder"

In vivo and in vitro activity of an immunoglobulin Fc fragment (Fcab) with engineered Her-2/neu binding sites

Autor: Florian Rüker, Kevin Moulder, Herta Steinkellner, Susanne Wiederkum, Radha Borrowdale, Geert C. Mudde, Max Woisetschläger, Manuela Kainer, Gordana Wozniak-Knopp, Bernhard Antes

Publikováno v: Biotechnology Journal. 9:844-851

Antigen-binding Fc fragments (Fcabs) are a new unique class of immunotherapeutics. They are small (50 kD) fully functional antibody alternatives that bind antigen and elicit effector functions such as antibody-dependent cytotoxicity (ADCC) and comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fee119c9de43de1192edf3af6a656e
https://doi.org/10.1002/biot.201300387

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Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display

Autor: Kevin Moulder, Max Woisetschläger, Michael W. Traxlmayr, Manuela Kainer, Christian Obinger, Susanne Wiederkum, Gerhard Stadlmayr, Elisabeth Lobner, Christoph Hasenhindl, Florian Rüker, Bernhard Antes

Publikováno v: Protein Engineering, Design and Selection. 26:255-265

An Fcab (Fc antigen binding) is a crystallizable fragment of IgG having C-terminal structural loops of CH3 domains engineered for antigen binding. Since introduction of novel binding sites might impair the immunoglobulin fold, repairing strategies ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b93198e9c9c0e25b2aa338b9621b45
https://doi.org/10.1093/protein/gzs102

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Abstract 3812: A best in class anti-CD38 antibody with antitumor and immune-modulatory properties

Autor: Nina Eissler, Haw Lu, JD Aurellano, Beatriz Goyenechea, Dominic P. Smethurst, Pascal Merchiers, Kevin Moulder, Sergio A. Quezada, Teresa Marafioti, Jake Y. Henry, Sarah L. Windler, Simone Filosto, Anne Goubier, Camilla Fairbairn, Andreas Lundqvist, Michael F. Maguire, Omar Duramad, Kristina Witt

Publikováno v: Cancer Research. 78:3812-3812

Targeting CD38 in multiple myeloma has resulted in outstanding responses. CD38 is widely expressed on myeloma cells and other hematological malignancies. Not much is known about its expression on solid tumors and its role in the immune system. We hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b28dfdace37836aae7a8f0fd225f680c
https://doi.org/10.1158/1538-7445.am2018-3812

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Abstract 2787: Generation of first-in-class anti-CD25 antibodies depleting Treg without interfering with IL2 signalling for cancer therapies

Autor: Frederick Arce Vargas, Kevin Moulder, Josephine Salimu, Aghiles Boughetane, Robert Dejonge, Isabelle Solomon, Beatriz Goyenechea, Sergio A. Quezada, Karl S. Peggs, Pascal Merchiers, Anne Goubier, Mark Brown

Publikováno v: Cancer Research. 78:2787-2787

Regulatory T cells (Treg) are key players of the suppressive tumour microenvironment (TME). Their presence is correlated with a bad prognosis in multiple cancers, while a greater ratio of effector T cells (Teff) to Treg is associated with improved ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::843677af6a5434fde38fb37af012f6de
https://doi.org/10.1158/1538-7445.am2018-2787

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A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis

Autor: Robert Rowlands, Mihriban Tuna, Joana Carvalho, Mateusz Wydro, Phil Jones, Geert C. Mudde, Anton Bauer, Max Woisetschläger, Sarah Weller, Kevin Moulder, Medcalf Melanie, Robert Pegram, John Haurum, Miguel Gaspar, Victoria Drewett, Kinmei Leung, Sun Haijun, Samine Isaac, Sarah Batey

Publikováno v: Molecular Therapy

FS102 is a HER2-specific Fcab (Fc fragment with antigen binding), which binds HER2 with high affinity and recognizes an epitope that does not overlap with those of trastuzumab or pertuzumab. In tumor cells that express high levels of HER2, FS102 caus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa44a839246a7cf065fef5fdd538890b
https://pubmed.ncbi.nlm.nih.gov/26606663

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Endocytosis and recycling of the complex between CD23 and HLA-DR in human B cells

Autor: Hannah J. Gould, Kevin Moulder, Brian J. Sutton, Kevin H. Jennings, Gary Christie, Sophia N. Karagiannis, Paul R. Murdock, John K. Warrack

Publikováno v: Immunology. 103:319-331

The presentation of extremely low doses of antigen to T cells is enhanced by immunoglobulin E (IgE)-dependent antigen focusing to CD23, the low-affinity receptor for IgE, expressed on activated B cells. CD23 contains a C-type lectin domain in its ext

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699b1ad86a53a89b778588bbc179d286
https://doi.org/10.1046/j.1365-2567.2001.01238.x

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IgE secretion is attenuated by an inhibitor of proteolytic processing of CD23 (FcɛRII)

Autor: Kevin Moulder, Lisa Marshall, Gregory P. Harper, Ruth J. Mayer, Michael J. Hansbury, Vivienne M. Spackman, Gary Christie, Brian Bolognese, Derek R. Buckle, Sheila M. Seal, Aisling Barton, Mark McCord, Richard M. Cook, Paul R. Murdock, Beverley Jane Weston

Publikováno v: European Journal of Immunology. 27:3228-3235

CD23, the low-affinity IgE receptor, is up-regulated on interleukin (IL)-4-stimulated B cells and monocytes, with a concomitant increase in the release of soluble fragments of CD23 (sCD23) into the medium by proteolytic processing of the surface-boun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd02c239fef7410a3eaebd99098144ef
https://doi.org/10.1002/eji.1830271221

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Alefacept selectively promotes NK cell-mediated deletion of CD45R0+ human T cells

Autor: Kevin Moulder, Geoffrey Morgan, Denis R. Alexander, Joanne C. Cooper, Gerard R. Majeau, Susanne Harding, Meena Subramanyam

Publikováno v: European journal of immunology. 33(3)

Modulation of the immune response using immunoglobulin fusion proteins has shown great promise for clinical immunotherapy of autoimmune diseases. Alefacept is an immunoglobulin fusion protein composed of the first extracellular domain of human LFA-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68fe7fdb07dafd4f5e48b2b6ebcee87
https://pubmed.ncbi.nlm.nih.gov/12616487

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CD23-mediated homotypic cell adhesion: the role of proteolysis

Autor: Aisling Barton, Beverley Weston, Kevin Moulder

Publikováno v: European journal of immunology. 23(9)

CD23 is a multifunctional molecule expressed by cells of lymphoid, myeloid and hematopoietic lineages. As a cell surface molecule CD23 acts both as a low-affinity receptor for IgE (Fc epsilon RII) and as a cell adhesion molecule. CD23 can undergo aut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f9ead74fe9d27e31a5d95beea067cb
https://pubmed.ncbi.nlm.nih.gov/8370388

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