Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Kevin Moreau"'
Autor:
Natalia V. Ortiz Zacarías, Sascha Röth, Jeremy D. Broekhuis, Daan van der Es, Kevin Moreau, Laura H. Heitman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8984 (2024)
CC chemokine receptor 2 (CCR2) has been linked to many inflammatory and immune diseases, making it a relevant drug target. Yet, all CCR2 antagonists developed so far have failed in clinical trials; thus, novel strategies are needed to target this rec
Externí odkaz:
https://doaj.org/article/6db528a29d49459988b2161f531381fd
Publikováno v:
QRB Discovery, Vol 3 (2022)
Changing torsional restraints on DNA is essential for the regulation of transcription. Torsional stress, introduced by RNA polymerase, can propagate along chromatin facilitating topological transitions and modulating the specific binding of transcrip
Externí odkaz:
https://doaj.org/article/1f61f22d680846e69691bae8165e357a
Publikováno v:
QRB Discovery, Vol 3 (2022)
Selective DNA binding by transcription factors (TFs) is crucial for the correct regulation of DNA transcription. In healthy cells, promoters of active genes are hypomethylated. A single CpG methylation within a TF response element (RE) may change the
Externí odkaz:
https://doaj.org/article/c2fb1446f4bf4efcbebb37cb21419524
Autor:
Stephanie Popa, Julien Villeneuve, Sarah Stewart, Esther Perez Garcia, Anna Petrunkina Harrison, Kevin Moreau
Publikováno v:
Wellcome Open Research, Vol 4 (2020)
Background: The fundamental process of protein secretion from eukaryotic cells has been well described for many years, yet gaps in our understanding of how this process is regulated remain. Methods: With the aim of identifying novel genes involved in
Externí odkaz:
https://doaj.org/article/19d17e7bbe744b99b8dbd241cdb38e2e
Publikováno v:
Nucleic Acids Research
Activator proteins 1 (AP-1) comprise one of the largest families of eukaryotic basic leucine zipper transcription factors. Despite advances in the characterization of AP-1 DNA-binding sites, our ability to predict new binding sites and explain how th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b04a68fb948e568f34dccb1435019d
https://doi.org/10.1093/nar/gkab691
https://doi.org/10.1093/nar/gkab691
Autor:
Maria-Anna Trapotsi, Elizabeth Mouchet, Guy Williams, Tiziana Monteverde, Karolina Juhani, Riku Turkki, Filip Miljković, Anton Martinsson, Lewis Mervin, Kenneth R. Pryde, Erik Müllers, Ian Barrett, Ola Engkvist, Andreas Bender, Kevin Moreau
Funder: AstraZeneca
PROteolysis TArgeting Chimeras (PROTACs) use the ubiquitin-proteasome system to degrade a protein of interest for therapeutic benefit. Advances made in targeted protein degradation technology have been remarkable, with severa
PROteolysis TArgeting Chimeras (PROTACs) use the ubiquitin-proteasome system to degrade a protein of interest for therapeutic benefit. Advances made in targeted protein degradation technology have been remarkable, with severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d888b3f3a2dcac91d7eedf99b7082c
Publikováno v:
SLAS Discovery. 26:518-523
Mass spectrometry-based proteomics profiling is a discovery tool that enables researchers to understand the mechanisms of action of drug candidates. When applied to proteolysis targeting chimeras (PROTACs) such approaches provide unbiased perspective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5251b9012618b03cdc776a059f0ee1
https://doi.org/10.1177/2472555220985776
https://doi.org/10.1177/2472555220985776
Publikováno v:
Drug Discovery Today. :103643
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c9f3c3a5f24165d93ff264917f5cc9f
https://doi.org/10.1016/j.drudis.2023.103643
https://doi.org/10.1016/j.drudis.2023.103643
Changing torsional restraints on DNA is essential for the regulation of transcription. Torsional stress, introduced by RNA polymerase, can propagate along chromatin facilitating topological transitions and modulating the specific binding of transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22c261151ba26fe6ee7377e9cfc294e2
https://doi.org/10.1101/2022.01.07.475332
https://doi.org/10.1101/2022.01.07.475332
Characterization and Pharmacological Validation of a Preclinical Model of NASH in Göttingen Minipigs
Autor:
Kevin Moreau, Valérie Paradis, Ludovic Lesage, Nicolas Lesueur, Franck Letourneur, Dominique Valla, Aurélie Helbert, Nathalie De Preville, Stéphanie Creusot, Adel Hammoutene, Tania Baltauss, Olivier Broux, Angelique Brzustowski, Philippe Delerive, Nicolas Provost, Edwige-Ludiwyne Hubert, Valérie Duvivier, Lindsay Gerard, Karine Lemaitre, Lucie Adoux, Julia Geronimi
Publikováno v:
Journal of clinical and experimental hepatology. 12(2)
Background Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, which is associated with features of metabolic syndrome. NAFLD may progress in a subset of patients into nonalcoholic steatohepatitis (NASH) with liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4550e912718ce47fe170ea0279e27f72
https://pubmed.ncbi.nlm.nih.gov/35535064
https://pubmed.ncbi.nlm.nih.gov/35535064