Výsledky vyhledávání - "Kevin Monaghan"

Akademický článek

Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium.

Autor: Kevin Monaghan, Jennifer McNaughten, Mary K McGahon, Catriona Kelly, Daniel Kyle, Phaik Har Yong, J Graham McGeown, Tim M Curtis

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128359 (2015)

Retinal endothelial cell dysfunction is believed to play a key role in the etiology and pathogenesis of diabetic retinopathy. Numerous studies have shown that TRPV4 channels are critically involved in maintaining normal endothelial cell function. In

Externí odkaz: https://doaj.org/article/f1f6d510271e4c8ca54ecd27467171dd

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TRPA1 activation in a human sensory neuronal model: relevance to cough hypersensitivity?

Autor: Fionnuala Lundy, Lorcan McGarvey, Gerard P. Sergeant, Tim M. Curtis, Kevin Monaghan, Rebecca Clarke, Caoimhin S. Griffin, Ikhlas El Karim, J. Graham McGeown, S. Louise Cosby, Imad About

Publikováno v: Clarke, R, Monaghan, K, About, I, Griffin, C S, Sergeant, G P, El Karim, I, McGeown, J G, Cosby, S L, Curtis, T M, McGarvey, L P & Lundy, F T 2017, ' TRPA1 activation in a human sensory neuronal model: relevance to cough hypersensitivity? ', European Respiratory Journal, vol. 50, no. 3, 1700995 . https://doi.org/10.1183/13993003.00995-2017
European Respiratory Journal
European Respiratory Journal, 2017, 50 (3), ⟨10.1183/13993003.00995-2017⟩
European Respiratory Journal, European Respiratory Society, 2017, 50 (3), ⟨10.1183/13993003.00995-2017⟩

International audience; The cough reflex becomes hyperresponsive in acute and chronic respiratory diseases, but understanding the underlying mechanism is hampered by difficulty accessing human tissue containing both nerve endings and neuronal cell bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c7f3ab40ffd2dad91e51aa9e404d07
https://pure.qub.ac.uk/en/publications/fe7c968f-8ede-4772-aa01-c84492242c92

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Mucosal modulation of contractility in bladder strips from normal and overactive rat models and the effect of botulinum toxin A on overactive bladder strips

Autor: Kevin Monaghan, Lauren Baysting, Oonagh Little, Bronagh McDonnell, Patrick C. Campbell, Karen D. McCloskey

Publikováno v: Campbell, P C, McDonnell, B, Monaghan, K P, Baysting, L, Little, O & McCloskey, K D 2017, ' Mucosal modulation of contractility in bladder strips from normal and overactive rat models and the effect of botulinum toxin A on overactive bladder strips ', Neurourology and Urodynamics, vol. 36, no. 4, pp. 1052-1060 . https://doi.org/10.1002/nau.23082

AIMS: To investigate the local, regulatory role of the mucosa on bladder strip contractility from normal and overactive bladders and to examine the effect of botulinum toxin A (BoNT-A).METHODS: Bladder strips from spontaneously hyperactive rat (SHR)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2b7e6c999db87f7304f06b9fc22380
https://pure.qub.ac.uk/en/publications/mucosal-modulation-of-contractility-in-bladder-strips-from-normal-and-overactive-rat-models-and-the-effect-of-botulinum-toxin-a-on-overactive-bladder-strips(06e1a423-9253-4ba8-aeb3-bd518b8a1f3e).html

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Identification of PDGFRα Positive Populations of Interstitial Cells in Human and Guinea Pig Bladders

Autor: Louise Johnston, Karen D. McCloskey, Kevin Monaghan

Publikováno v: Journal of Urology. 188:639-647

The bladder wall comprises a complex array of cells, including urothelium, smooth muscle, nerves and interstitial cells. Interstitial cells have several subtypes based on site, morphology and differential expression of markers such as anti-vimentin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45491e1e0a53be540012fd5a699566ce
https://doi.org/10.1016/j.juro.2012.03.117

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Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block

Autor: Michael W. Pennington, Alexander Flügel, Kevin Monaghan, Adriana Garcia, K. George Chandy, Srikant Rangaraju, Ian Parker, Victor Chi, Olga Safrina, Christine Beeton, Edwin S. Monuki, Sukumar Pal, Melanie P. Matheu, Michael D. Cahalan, Marc Uemura, Luis M. de la Maza, Dan Li

Publikováno v: Immunity. 29(4):602-614

SummaryEffector memory T (Tem) cells are essential mediators of autoimmune disease and delayed-type hypersensitivity (DTH), a convenient model for two-photon imaging of Tem cell participation in an inflammatory response. Shortly (3 hr) after entry in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1eb5a73325e1dcfb8598969a3fadf93

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A pH-sensitive potassium conductance (TASK) and its function in the murine gastrointestinal tract

Autor: Kenton M. Sanders, Salah A. Baker, Elizabeth A. H. Beckett, Sean M. Ward, Insoo Han, Kyu Joo Park, Kevin Monaghan, Sang Yun Cho, Sang Don Koh

Publikováno v: The Journal of Physiology. 565:243-259

The excitability of smooth muscles is regulated, in part, by background K+ conductances that determine resting membrane potential. However, the K+ conductances so far described in gastrointestinal (GI) muscles are not sufficient to explain the negati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f44672e22d856063889ebd41ac89505a
https://doi.org/10.1113/jphysiol.2005.084574

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Mechanism of active repolarization of inhibitory junction potential in murine colon

Autor: Kevin Monaghan, Kenton M. Sanders, Sang Don Koh, Violeta N. Mutafova-Yambolieva, Burton Horowitz, Salah A. Baker

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 285:G813-G821

Enteric inhibitory responses in gastrointestinal (GI) smooth muscles involve membrane hyperpolarization that transiently reduce the excitability of GI muscles. We examined the possibility that an active repolarization mechanism participates in the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c80cb927754e659dc1019d92886054
https://doi.org/10.1152/ajpgi.00115.2003

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TREK-1 Regulation by Nitric Oxide and cGMP-dependent Protein Kinase

Autor: Kenton M. Sanders, Rebecca L. Walker, Kevin Monaghan, Seungil Ro, Burton Horowitz, Sang Don Koh, Gerard P. Sergeant

Publikováno v: Journal of Biological Chemistry. 276:44338-44346

Potassium channels activated by membrane stretch may contribute to maintenance of relaxation of smooth muscle cells in visceral hollow organs. Previous work has identified K(+) channels in murine colon that are activated by stretch and further regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a183bd5cffbe301fd95d5f0f91a3cefe
https://doi.org/10.1074/jbc.m108125200

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Novel voltage‐dependent non‐selective cation conductance in murine colonic myocytes

Autor: James L. Kenyon, Kevin Monaghan, Sang Don Koh, Kenton M. Sanders, Helen S. Mason, Seungil Ro

Publikováno v: The Journal of Physiology. 533:341-355

1. Two components of voltage-gated, inward currents were observed from murine colonic myocytes. One component had properties of L-type Ca(2+) currents and was inhibited by nicardipine (5 x 10(-7) M). A second component did not 'run down' during dialy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82376c0cad6afce8848890c61c11fa8b
https://doi.org/10.1111/j.1469-7793.2001.0341a.x

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GABAergic control of arteriolar diameter in the rat retina

Autor: J. Graham McGeown, Bente Frølund, Kevin Hinds, Kevin Monaghan, Tim M. Curtis

Publikováno v: Investigative ophthalmologyvisual science. 54(10)

PURPOSE To investigate the role of γ-aminobutryic acid (GABA) in the regulation of arteriolar diameter in the rat retina. METHODS The actions of GABA on arteriolar diameter were examined using ex vivo retinal whole-mount preparations and isolated ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf428cbd33f95fea55a617c3287acca
https://pubmed.ncbi.nlm.nih.gov/24045989

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