Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kevin Melody"'
Autor:
Robert W. Cross, Zachary A. Bornholdt, Abhishek N. Prasad, Joan B. Geisbert, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Kevin Melody, Karla A. Fenton, Heinz Feldmann, Armand Sprecher, Larry Zeitlin, Thomas W. Geisbert
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
During an ongoing Ebola virus outbreak, infection before onset of protective immunity from vaccination is a possible scenario. Here the authors show in non-human primates that vaccination shortly before treatment with a monoclonal antibody does not n
Externí odkaz:
https://doaj.org/article/f42ceaff066b4e269cda66de8d4403a1
Autor:
Yash Agarwal, Cole Beatty, Shivkumar Biradar, Isabella Castronova, Sara Ho, Kevin Melody, Moses Turkle Bility
Publikováno v:
Retrovirology, Vol 17, Iss 1, Pp 1-11 (2020)
Abstract The development of safe and effective combination antiretroviral therapies for human immunodeficiency virus (HIV) infection over the past several decades has significantly reduced HIV-associated morbidity and mortality. Additionally, antiret
Externí odkaz:
https://doaj.org/article/8ecf8a87a25048e29a9cccb9a266617a
Autor:
Stephanie L. Foster, Thomas W. Geisbert, John C. Heymann, Daniel J. Deer, Krystle N. Agans, Viktoriya Borisevich, Liana Medina, Corri B. Levine, Kevin Melody, Natalie S. Dobias, Joan B. Geisbert, Abhishek N. Prasad, Karla A. Fenton, Courtney Woolsey, Robert W. Cross
Publikováno v:
Nature immunology
bioRxiv
article-version (status) pre
article-version (number) 1
Nature Immunology
bioRxiv
article-version (status) pre
article-version (number) 1
Nature Immunology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19. Animal models are urgently needed to study the pathogenesis of COVID-19 and to screen vaccines and treatments. We show Afric
Autor:
Krystle N. Agans, Kevin Melody, Karla A. Fenton, Viktoriya Borisevich, Daniel J. Deer, John C. Heymann, Courtney Woolsey, Liana Medina, Abhishek N. Prasad, Corri B. Levine, Thomas W. Geisbert, Natalie S. Dobias, Stephanie L. Foster, Robert W. Cross, Joan B. Geisbert
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19. Animal models are urgently needed to study the pathogenesis of COVID-19 and to screen candidate vaccines and treatments. Non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::712bc24a2874a5dab991f9e0d2fdd560
https://doi.org/10.1101/2020.05.17.100289
https://doi.org/10.1101/2020.05.17.100289
Autor:
Zachary A. Bornholdt, Robert W. Cross, Thomas W. Geisbert, Kevin Melody, Karla A. Fenton, Daniel J. Deer, Armand Sprecher, Heinz Feldmann, Larry Zeitlin, Joan B. Geisbert, Krystle N. Agans, Viktoriya Borisevich, Abhishek N. Prasad
A replication-competent, vesicular stomatitis virus vaccine expressing the Ebola virus (EBOV) glycoprotein (GP) (rVSV-ZEBOV) was successfully used during the 2013-16 EBOV epidemic1. Additionally, chimeric and human monoclonal antibodies (mAb) against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e794ba8958878834ba111b52930c5de6
https://doi.org/10.1101/2020.04.01.018275
https://doi.org/10.1101/2020.04.01.018275
Autor:
Angela D. M. Kashuba, Kevin Melody, Pleuni S. Pennings, Mackenzie L. Cottrell, Moses T. Bility, Zandrea Ambrose, Kathleen A. Shutt, Dwayne Evans, Brandon F. Keele, Christopher E. Kline, Chandra Nath Roy
Publikováno v:
Journal of Virology
The antiretroviral drug rilpivirine was developed into a long-acting formulation (RPV LA) to improve adherence for preexposure prophylaxis (PrEP) to prevent HIV-1 transmission. A concern is that RPV LA will not inhibit transmission of drug-resistant
Autor:
Paul L. Boyer, Linda L. Dunn, Steven J. Smith, Richa Dwivedi, Douglas K. Fischer, Pat Clark, Stephen H. Hughes, Chris Kline, Kevin Melody, Zandrea Ambrose
Publikováno v:
Journal of Virology
Although antiretroviral therapy (ART) is highly successful, drug-resistant variants can arise that blunt the efficacy of ART. New inhibitors that are broadly effective against known drug-resistant variants are needed, although such compounds might se
Autor:
Stephen H. Hughes, Gary T. Pauly, Kevin Melody, Aamir Akram, Joel P. Schneider, Steven J. Smith, Zandrea Ambrose
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 72:485-491
Background Rilpivirine (RPV) is the latest non-nucleoside reverse transcriptase inhibitor (NNRTI) to be approved by Food and Drug Administration to combat HIV-1 infections. NNRTIs inhibit the chemical step in viral DNA synthesis by binding to an allo
Autor:
Abdallah Elhakiem, Kevin Melody, Moses T. Bility, Jasmine Samal, Samantha Kelly, Anwesha Sanyal, Phalguni Gupta, Ali Na-Shatal, Antu Das, Ming Ding, Watfa Ahmed, Aala Zakir, Brad Roland
Publikováno v:
JCI Insight. 3
A major pathogenic feature associated with HIV infection is lymphoid fibrosis, which persists during antiretroviral therapy (ART). Lymphoid tissues play critical roles in the generation of antigen-specific immune response, and fibrosis disrupts the s
Autor:
David J. Maloney, Joel T. Schneider, Ganesha Rai, Craig J. Thomas, Zandrea Ambrose, Aamir Akram, Steven J. Smith, Stephen H. Hughes, Kevin Melody, Gary T. Pauly
Publikováno v:
Retrovirology
Background Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are a class of antiretroviral compounds that bind in an allosteric binding pocket in HIV-1 RT, located about 10 Å from the polymerase active site. Binding of an NNRTI causes structu