Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Kevin M. Woolfrey"'
Autor:
Kevin P. Koster, Zach Fyke, Thu T. A. Nguyen, Amanda Niqula, Lorena Y. Noriega-González, Kevin M. Woolfrey, Mark L. Dell’Acqua, Stephanie M. Cologna, Akira Yoshii
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 16 (2024)
Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation. The depalmitoylating enzyme, palmitoyl-protein thioesterase 1 (PPT1), is associat
Externí odkaz:
https://doaj.org/article/e3a613aeb95d49d588cfd343ac8d71e8
Autor:
Alicia M. Purkey, Kevin M. Woolfrey, Kevin C. Crosby, Dominik G. Stich, Wallace S. Chick, Jason Aoto, Mark L. Dell’Acqua
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 974-987.e4 (2018)
Summary: Ca2+-permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term potentiation (LTP), but mechanisms regulating CP-AMPARs are poorly
Externí odkaz:
https://doaj.org/article/5cfe45e1aa0144229d4b3260ef3ae995
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Structural plasticity of excitatory synapses is a vital component of neuronal development, synaptic plasticity, and behaviour. Abnormal development or regulation of excitatory synapses has also been strongly implicated in many neurodevelopmental, psy
Externí odkaz:
https://doaj.org/article/70492a302ee04479930932fbe254ea4b
Autor:
Deepak P Srivastava, Kevin M Woolfrey, Kelly A Jones, Charles T Anderson, Katharine R Smith, Theron A Russell, Hyerin Lee, Marina V Yasvoina, David L Wokosin, P Hande Ozdinler, Gordon M G Shepherd, Peter Penzes
Publikováno v:
PLoS Biology, Vol 10, Iss 6, p e1001350 (2012)
The architecture of dendritic arbors determines circuit connectivity, receptive fields, and computational properties of neurons, and dendritic structure is impaired in several psychiatric disorders. While apical and basal dendritic compartments of py
Externí odkaz:
https://doaj.org/article/82bebeeb8c44423d9a906dbfb32001e3
Autor:
Emily S. Gibson, Patrick G. Hogan, Raphael A. Nemenoff, Huiming Li, Mark L. Dell'Acqua, Lynn E. Heasley, Kevin M. Woolfrey
Publikováno v:
Molecular Pharmacology. 95:20-32
Calcineurin (CaN) phosphatase signaling is regulated by targeting CaN to substrates, inhibitors, and scaffold proteins containing docking motifs with the consensus sequence of PxIxIT. Here, we identify the docking of CaN to the γ isoform of MKK7, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fd0e045f150921251963fa32ebc1bc0
https://doi.org/10.1124/mol.118.113159
https://doi.org/10.1124/mol.118.113159
Publikováno v:
Jones, K A, Sumiya, M, Woolfrey, K M, Srivastava, D P & Penzes, P 2019, ' Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density ', Molecular and Cellular Neuroscience, vol. 98, pp. 19-31 . https://doi.org/10.1016/j.mcn.2019.05.001
Molecular and Cellular Neurosciences
Molecular and Cellular Neurosciences
EPAC2 is a guanine nucleotide exchange factor that regulates GTPase activity of the small GTPase Rap and Ras and is highly enriched at synapses. Activation of EPAC2 has been shown to induce dendritic spine shrinkage and increase spine motility, effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe990239fdbd8f05585f80a8a4fd8cc
https://kclpure.kcl.ac.uk/en/publications/c847e0e9-5c8b-4c05-a4e6-728c0f027f04
https://kclpure.kcl.ac.uk/en/publications/c847e0e9-5c8b-4c05-a4e6-728c0f027f04
Autor:
Mark L. Dell'Acqua, John Meitzen, Stephen A. Schnell, Samuel P. Swanson, Kevin M. Woolfrey, Katherine R. Tonn Eisinger, Paul G. Mermelstein
Palmitoylation is a reversible post-translational addition of a 16-carbon lipid chain involved in trafficking and compartmentalizing target proteins. It is important for many cellular functions, including signaling via membrane-localized estrogen rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b18cd2a71f7793c8075b22a0515b82
https://europepmc.org/articles/PMC6187622/
https://europepmc.org/articles/PMC6187622/
Autor:
Mark L. Dell'Acqua, Kevin M. Woolfrey
Publikováno v:
Journal of Biological Chemistry. 290:28604-28612
A central theme in nervous system function is equilibrium: synaptic strengths wax and wane, neuronal firing rates adjust up and down, and neural circuits balance excitation with inhibition. This push/pull regulatory theme carries through to the molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6d60db07529a6fc971fb8caca79993
https://doi.org/10.1074/jbc.r115.657262
https://doi.org/10.1074/jbc.r115.657262
Autor:
Eric A. Horne, Heather O'Leary, Mark L. Dell'Acqua, Holly R. Robertson, K. Ulrich Bayer, Steven J. Coultrap, Kevin M. Woolfrey, Dayton J. Goodell
Publikováno v:
The Journal of biological chemistry. 293(5)
Both long-term potentiation (LTP) and depression (LTD) of excitatory synapse strength require the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) and its autonomous activity generated by Thr-286 autophosphorylation. Additionally, LTP and L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113151304b4628eb2616093d044cb0b5
https://pubmed.ncbi.nlm.nih.gov/29196604
https://pubmed.ncbi.nlm.nih.gov/29196604
Autor:
Kevin M. Woolfrey, Mark L. Dell'Acqua
Publikováno v:
Nature Neuroscience. 21:1021-1022
Protein kinases are key regulators of excitatory synapse plasticity. In this issue, using novel optical reporters of protein kinase C (PKC) activity, Colgan et al. identify PKCα as critical for integrating NMDA receptor and neurotrophin signaling to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030c76d2df125a37544783e6d45e68c8
https://doi.org/10.1038/s41593-018-0190-5
https://doi.org/10.1038/s41593-018-0190-5