Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kevin M. Walton"'
Autor:
Asim H. Gazi, Anna B. Harrison, Tamara P. Lambert, Malik Obideen, Parvaneh Alavi, Nancy Murrah, Lucy Shallenberger, Emily G. Driggers, Rebeca Alvarado Ortega, Brianna P. Washington, Kevin M. Walton, Justine W. Welsh, Viola Vaccarino, Amit J. Shah, Yi-Lang Tang, Rahul Gupta, Sudie E. Back, Omer T. Inan, J. Douglas Bremner
Publikováno v:
Brain Stimulation, Vol 15, Iss 5, Pp 1206-1214 (2022)
Background: Opioid Use Disorder (OUD) is a serious public health problem, and the behavioral and physiological effects of opioid withdrawal can be a major impediment to recovery. Medication for OUD is currently the mainstay of treatment; however, it
Externí odkaz:
https://doaj.org/article/09d563ad90524a5f9f2922735fbd8670
Autor:
Kevin M. Walton, Evan S. Herrmann
Publikováno v:
Addiction Neuroscience, Vol 6, Iss , Pp 100069- (2023)
Adherence is a critical mediator of treatment outcome across health conditions and low rates of adherence undermine success in smoking cessation treatment. This narrative review provides an overview of different techniques that can be used to measure
Externí odkaz:
https://doaj.org/article/4f847367c6ce4493bf8d670c5b3e87ae
Autor:
Tamara P. Lambert, Asim H. Gazi, Anna B. Harrison, Sevda Gharehbaghi, Michael Chan, Malik Obideen, Parvaneh Alavi, Nancy Murrah, Lucy Shallenberger, Emily G. Driggers, Rebeca Alvarado Ortega, Brianna Washington, Kevin M. Walton, Yi-Lang Tang, Rahul Gupta, Jonathon A. Nye, Justine W. Welsh, Viola Vaccarino, Amit J. Shah, J. Douglas Bremner, Omer T. Inan
Publikováno v:
Biosensors, Vol 12, Iss 11, p 924 (2022)
Treating opioid use disorder (OUD) is a significant healthcare challenge in the United States. Remaining abstinent from opioids is challenging for individuals with OUD due to withdrawal symptoms that include restlessness. However, to our knowledge, s
Externí odkaz:
https://doaj.org/article/f208ea4616484e5b9322f3376c660155
Autor:
Eric K. Soule, Scott McIntosh, Rachel Grana, Simani M. Price, Maansi Bansal-Travers, Kevin M. Walton, Jennifer B. Unger
Publikováno v:
Tob Control
Assessing tobacco use intensity allows researchers to examine tobacco use in greater detail than assessing ever or current use only. Tobacco use intensity measures have been developed that are specific to tobacco products, such as asking smokers to r
Publikováno v:
Drug and alcohol dependence. 229
Substance Use Disorders (SUDs) have a substantial adverse impact in the United States, with more than $700 billion annually in health care expenditures and lost earnings. 1 The incidence is widespread; approximately 21.6 million individuals over the
Autor:
Jack E. Henningfield, Kevin M. Walton, Jed E. Rose, Lisa Postow, Maciej L. Goniewicz, Thomas Eissenberg, Lynne Haverkos, Michael C. Fiore, Gregory N. Connolly, David B. Abrams, John R. Hughes, Dorothy K. Hatsukami, Cheryl Oncken, Stephen S. Hecht, David Clark, Kay Wanke, William C. Bailey, Mirjana V. Djordjevic, Lucie Yang
Publikováno v:
Nicotinetobacco research : official journal of the Society for Research on Nicotine and Tobacco. 17(2)
Electronic cigarettes (e-cigarettes) represent an emerging public health issue. These devices deliver nicotine along with other constituents, including flavorants, via an inhalable aerosol. Their uptake is rapidly increasing in both adults and youths
Autor:
Kevin M. Walton, Jeff Ohren, John D. Knafels, Amy Rosado, Travis T. Wager, Butler Todd W, Andy N. Mead, Blossom Sneed, Katherine Fisher, David Horton, Shenping Liu, George J DeMarco, Scot Richard Mente, Helen Berke, Angela C. Doran, Cheng Chang, Jenifer Bradley, Michael Marconi, Ramalakshmi Yegna Chandrasekaran, David M. Rubitski
Publikováno v:
ACS chemical neuroscience. 5(12)
Casein kinase 1 delta (CK1δ) and casein kinase 1 epsilon (CK1ε) inhibitors are potential therapeutic agents for a range of psychiatric disorders. The feasibility of developing a CNS kinase inhibitor has been limited by an inability to identify safe
Autor:
John M. Humphrey, Shenping Liu, Jeff Ohren, Katherine Fisher, Ramalakshmi Yegna Chandrasekaran, Kevin M. Walton, Kevin Cherry, Butler Todd W, W. Scott McDonald, Eric P. Arnold, Jianke Li, Ken Dirico, Angela C. Doran, Blossom Sneed, Travis T. Wager, Subramanyam Chakrapani, Michael Eric Green, Scot Richard Mente, John D. Knafels, Matthew Merrill Hayward, Paul Galatsis, Vanessa Paradis, Michael Marconi
Publikováno v:
Journal of medicinal chemistry. 56(17)
Casein kinase 1δ (CK1δ) and 1e (CK1e) are believed to be necessary enzymes for the regulation of circadian rhythms in all mammals. On the basis of our previously published work demonstrating a CK1e-preferring compound to be an ineffective circadian
Autor:
Angela C. Doran, Cheng Chang, Kevin M. Walton, Jae Kyoung Kim, Michael Marconi, Travis T. Wager, Daniel B. Forger, D. Wood
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Circadian rhythms can be entrained by a light-dark (LD) cycle and can also be reset pharmacologically, for example, by the CK1δ/ε inhibitor PF-670462. Here, we determine how these two independent signals affect circadian timekeeping from the molecu
Autor:
Sandrine M. Dupre, Andrew S. I. Loudon, Elizabeth S. Maywood, Michael H. Hastings, Travis T. Wager, Francis Rajamohan, John D. Knafels, Jeffrey F. Ohren, Jian Li, Johanna E. Chesham, Laura E. Zawadzke, Wei Qun Lu, David A. Bechtold, Kevin M. Walton, Julie E. Gibbs, Blossom Sneed, Qing-Jun Meng
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(34)
Circadian pacemaking requires the orderly synthesis, posttranslational modification, and degradation of clock proteins. In mammals, mutations in casein kinase 1 (CK1) ε or δ can alter the circadian period, but the particular functions of the WT iso