Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kevin M. Ruley"'
Autor:
Asim B. Dey, Sherif Khedr, James Bean, Leah L. Porras, Tamika D. Meredith, Francis S. Willard, Joseph V. Hass, Xin Zhou, Maia Terashvili, Cynthia D. Jesudason, Kevin M. Ruley, Michael R. Wiley, Mark Kowala, Simon J. Atkinson, Alexander Staruschenko, Mark D. Rekhter
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Regulation of the peripheral vascular resistance via modulating the vessel diameter has been considered as a main determinant of the arterial blood pressure. Phosphodiesterase enzymes (PDE1-11) hydrolyse cyclic nucleotides, which are key players cont
Externí odkaz:
https://doaj.org/article/b4baa1cb29d4475abaa7c717aa8cd7e6
Autor:
Shuiyu, Lu, Mohammad B, Haskali, Kevin M, Ruley, Nicolas J-F, Dreyfus, Susan L, DuBois, Soumen, Paul, Jeih-San, Liow, Cheryl L, Morse, Aneta, Kowalski, Robert L, Gladding, Jeremy, Gilmore, Adrian J, Mogg, S Michelle, Morin, Peter J, Lindsay-Scott, J Craig, Ruble, Nancy A, Kant, Sergey, Shcherbinin, Vanessa N, Barth, Michael P, Johnson, Maria, Cuadrado, Enrique, Jambrina, Andrew J, Mannes, Hugh N, Nuthall, Sami S, Zoghbi, Cynthia D, Jesudason, Robert B, Innis, Victor W, Pike
Publikováno v:
Sci Transl Med
We aimed to develop effective radioligands for quantifying brain O-linked-β-N-acetyl-glucosamine (O-GlcNAc) hydrolase (OGA) using positron emission tomography in living subjects as tools for evaluating drug target engagement. Post-translational modi