Visualization-assisted binning of metagenome assemblies reveals potential new pathogenic profiles in idiopathic travelers’ diarrhea

Autor: Qiyun Zhu, Christopher L. Dupont, Marcus B. Jones, Kevin M. Pham, Zhi-Dong Jiang, Herbert L. DuPont, Sarah K. Highlander

Publikováno v: Microbiome, Vol 6, Iss 1, Pp 1-20 (2018)

Abstract Background Travelers’ diarrhea (TD) is often caused by enterotoxigenic Escherichia coli, enteroaggregative E. coli, other bacterial pathogens, Norovirus, and occasionally parasites. Nevertheless, standard diagnostic methods fail to identif

Externí odkaz: https://doaj.org/article/e749764ce0fa484e98f8916916ec9fcf

Selective Inhibition of ADAR1 Using 8-Azanebularine-Modified RNA Duplexes

Autor: Herra G. Mendoza, Victorio Jauregui Matos, SeHee Park, Kevin M. Pham, Peter A. Beal

Publikováno v: Biochemistry. 62:1376-1387

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ec52e82174c0ac1ba46d3569700d339
https://doi.org/10.1021/acs.biochem.2c00686

Ester modification at the 3' end of anti-microRNA oligonucleotides increases potency of microRNA inhibition

Autor: Shannon S. Lu, Scott R. Suter, Peter A. Beal, Kevin M. Pham

Publikováno v: Bioorg Med Chem

MicroRNAs (miRNAs) are short noncoding RNAs that play a fundamental role in gene regulation. Deregulation of miRNA expression has a strong correlation with disease and antisense oligonucleotides that bind and inhibit miRNAs associated with disease ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422f50569313365a614df66472c84ccc
https://pubmed.ncbi.nlm.nih.gov/33290908

Taxon-specific aerosolization of bacteria and viruses in an experimental ocean-atmosphere mesocosm

Autor: R. Alexander Richter, Drishti Kaul, Luke R. Thompson, Rob Knight, Charlotte M. Beall, Zhenjiang Zech Xu, Jennifer M. Michaud, Josh L. Espinoza, Christopher Lee, Michael D. Burkart, Kimberly A. Prather, Farooq Azam, Christopher L. Dupont, Kevin M. Pham, Francesca Malfatti

Publikováno v: Michaud, JM; Thompson, LR; Kaul, D; Espinoza, JL; Richter, RA; Xu, ZZ; et al.(2018). Taxon-specific aerosolization of bacteria and viruses in an experimental ocean-atmosphere mesocosm. NATURE COMMUNICATIONS, 9. doi: 10.1038/s41467-018-04409-z. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/8t69s8pk
Nature communications, vol 9, iss 1
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Ocean-derived, airborne microbes play important roles in Earth’s climate system and human health, yet little is known about factors controlling their transfer from the ocean to the atmosphere. Here, we study microbiomes of isolated sea spray aeroso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e25df7e8f5891639912908050c934a
http://www.escholarship.org/uc/item/8t69s8pk

Tapping a bacterial enzymatic pathway for the preparation and manipulation of synthetic nanomaterials

Autor: Nathan C. Gianneschi, Ti-Hsuan Ku, Kevin M. Pham, Michael D. Burkart, Swagat Sahu, Nicolas M. Kosa

Publikováno v: Journal of the American Chemical Society. 136(50)

We present a spherical micelle generated in a three-step sequence in which a farnesyl-pantetheine conjugate is phosphorylated, adenylated, and phosphorylated once more to generate a farnesyl-CoA amphiphile that self-assembles into spherical micelles.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65eb54962cb5a519315d0f8701ee6b1
https://pubmed.ncbi.nlm.nih.gov/25468257