Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Kevin M. Mullane"'
Publikováno v:
Biochemical Pharmacology. 97:225-235
Recent reports have highlighted studies in biomedical research that cannot be reproduced, tending to undermine the credibility, relevance and sustainability of the research process. To address this issue, a number of factors can be monitored to impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac015c5442c636a0b8e474e26bcc6754
https://doi.org/10.1016/j.bcp.2015.06.023
https://doi.org/10.1016/j.bcp.2015.06.023
Autor:
Michael Williams, Kevin M. Mullane
Publikováno v:
Biochemical Pharmacology. 97:133-136
The credibility and consequent sustainability of the biomedical research “ecosystem” is in jeopardy, in part due to an inability to reproduce data from the peer-reviewed literature. Despite obvious and relatively inexpensive solutions to improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d16289a3ff30a58b8b0cba337d5fec
https://doi.org/10.1016/j.bcp.2015.07.002
https://doi.org/10.1016/j.bcp.2015.07.002
Autor:
Myron L. Toews, Kevin M. Mullane, Raymond J. Winquist, David B. Bylund, Michael Williams, Terry P. Kenakin
Publikováno v:
Biochemical Pharmacology. 87:64-77
A pharmacological experiment is typically conducted to: i) test or expand a hypothesis regarding the potential role of a target in the mechanism(s) underlying a disease state using an existing drug or tool compound in normal and/or diseased tissue or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b26eae306d658a6b1ffb4e1d705a87
https://doi.org/10.1016/j.bcp.2013.10.024
https://doi.org/10.1016/j.bcp.2013.10.024
Autor:
Michael Williams, Kevin M. Mullane
Publikováno v:
Biochemical Pharmacology. 87:131-139
Animal models of disease represent the pinnacle of hierarchical research efforts to validate targets and compounds for therapeutic intervention. Yet models of asthma, particularly in the mouse, which, for practical reasons, has become the sine qua no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be99b09ec1567d952bab94cec33b61db
https://doi.org/10.1016/j.bcp.2013.06.026
https://doi.org/10.1016/j.bcp.2013.06.026
Publikováno v:
Biochemical Pharmacology. 87:189-210
The translational sciences represent the core element in enabling and utilizing the output from the biomedical sciences and to improving drug discovery metrics by reducing the attrition rate as compounds move from preclinical research to clinical pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5046e007b3d1431c98b52de674dadb
https://doi.org/10.1016/j.bcp.2013.10.019
https://doi.org/10.1016/j.bcp.2013.10.019
Autor:
Michael Williams, Kevin M. Mullane
Publikováno v:
Biochemical Pharmacology. 85:289-305
The worldwide incidence of Alzheimer's disease (AD) is increasing with estimates that 115 million individuals will have AD by 2050, creating an unsustainable healthcare challenge due to a lack of effective treatment options highlighted by multiple cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee11cc69448935170015869c39ff5f0b
https://doi.org/10.1016/j.bcp.2012.11.014
https://doi.org/10.1016/j.bcp.2012.11.014
Autor:
Kevin M. Mullane, Michael Williams
Publikováno v:
Drug Discovery Today. 17:459-468
The successful transition of drug-like new chemical entities from discovery to clinical trials coupled with real-time feedback from the latter represents a key element for success in drug discovery. Now designated as T1 translational medicine, this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab7ae317e375798ed7c151881e89fe1
https://doi.org/10.1016/j.drudis.2012.01.004
https://doi.org/10.1016/j.drudis.2012.01.004
Autor:
Kevin M. Mullane
Publikováno v:
Biochemical Pharmacology. 82:586-599
The prevalence of asthma continues to rise. Current drugs provide symptomatic relief to some, but not all, patients. Despite the need for new therapeutics, and a huge research effort, only four novel agents from two classes of drugs - the antileukotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dff251c073072140aa99af0678ef016
https://doi.org/10.1016/j.bcp.2011.06.033
https://doi.org/10.1016/j.bcp.2011.06.033
Publikováno v:
Biochemical Pharmacology. 87:1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56623ec29f5bb23d4461a3a4406de644
https://doi.org/10.1016/j.bcp.2013.10.018
https://doi.org/10.1016/j.bcp.2013.10.018
Publikováno v:
European Journal of Pharmacology. 322:211-220
Adenosine is cardioprotective in models of myocardial stunning and infarction, but the precise compartment within the heart in which adenosine elicits its cardioprotective effects has not been determined. The goals of the present study were to (i) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc3a11d7fb8365c5f87f405d185079f
https://doi.org/10.1016/s0014-2999(97)00011-3
https://doi.org/10.1016/s0014-2999(97)00011-3