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Autor:
Miyuki Hayashi, Amandeep Girdhar, Ying-Hui Ko, Kevin M. Kim, Jacquelyn A. DePierro, Joseph R. Buchler, Nikhita Arunprakash, Aditya Bajaj, Gino Cingolani, Lin Guo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Importin β-superfamily nuclear import receptors (NIRs) mitigate mislocalization and aggregation of RNA-binding proteins (RBPs), like FUS and TDP-43, which are implicated in neurodegenerative diseases. NIRs potently disaggregate RBPs by reco
Externí odkaz:
https://doaj.org/article/5cf3c1d8b89a4dc78f404d31b0c86da0